Antibodies for Neurodegenerative Diseases Research

Many neurodegenerative diseases of the central nervous system (CNS) are proteinopathies-diseases caused by malformed, misfolded, proteins. Cognitive abilities and motor functions are impaired, and many of these diseases are fatal. A great number of these proteinopathies are genetic, running in families or due to genetic mutation. Others may be triggered by factors such as tumors, stroke, environmental toxins, or viruses. While there are drugs that provide relief from the symptoms of these incurable and disabling disorders, the goal is to slow the progression or reverse the damage that causes them. This requires an understanding of the mechanisms responsible for their pathologies. Antibodies that can recognize and remove misshapen proteins are a proven approach for proteinopathy therapeutics and research on possible cures for neurodegenerative disease.

Sigma-Aldrich offers a broad range of monoclonal and polyclonal primary antibodies for neurodegenerative disease research. Categories include Alzheimer′s Disease (AD), Huntington′s Disease (HD), Parkinson′s Disease (PD), ALS, and various prion diseases.