Antibodies to Ligand-Gated Ion Channels

Ligand-gated ion channels are located in cellular membranes. These intrinsic ion channels change shape upon the binding of an extracellular ligand (an ion or molecule) to the binding site of the channel. This structural change opens the channel pore, allowing ion transport across the membrane. The pore is composed of five molecular subunits, which are in turn composed of a large extracellular domain (which contains the ligand binding site) and four transmembrane domains. Many diseases arise from the abnormal functioning of ligand-gated ion channels. Sigma-Aldrich has numerous antibodies for ligand-gated ion channel receptors, specifically targeting GABA, Glycine, Glutamate, Nicotinic Acetylcholine, and P2X. These substances come in many forms-- affinity isolated antibodies, IgG fractions of antiserum, purified immunoglobulin, and chemical compounds. They are reactive in human, rat, and various other species, with various applications.