Adjuvant Reagents

Adjuvants are mixtures of natural or synthetic compounds that, when administered with antigens, enhance the immune response. Adjuvants are used to (1) stimulate an immune response to an antigen that is not inherently immunogenic, (2) increase the intensity of the immune response, (3) preferentially stimulate either a cellular or a humoral response (i.e., protection from disease versus antibody production). Adjuvants have four main modes of action: enhanced antigen uptake and localization, extended antigen release, macrophage activation, and T and B cell stimulation. The most commonly used adjuvants fall into six categories: mineral salts, oil emulsions, microbacterial products, saponins, synthetic products and cytokines. Table I gives examples of various adjuvants and their properties. Applications are given in Table II.

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A0362 Adjuplex Vaccine Adjuvant Concentrate, sterile
S6322 Sigma Adjuvant System® oil
F5881 Freund’s Adjuvant, Complete cell suspension
F5506 Freund’s Adjuvant, Incomplete liquid
H7017 Hemocyanin from Megathura crenulata (keyhole limpet)
H8283 Hemocyanin from Megathura crenulata (keyhole limpet) PBS solution
B8556 Hemocyanin from mollusk buffered aqueous solution
B7542 Maleimide Activated BSA
P2870 Pristane synthetic, ≥98% (GC)
P9622 Pristane synthetic, liquid, sterile-filtered, BioReagent
H4397 TiterMax® Classic Adjuvant liquid
T2684 TiterMax® Gold Adjuvant liquid