Duolink® PLA – Protein Detection Technology

Amplified Detection

Inside every cell, there is a breakthrough waiting to be uncovered. The chance to change the origin of a human disease or discover the tell-tale sign of an irregular protein-protein interaction requires a powerful investigative tool and a streamlined approach. Rely on Duolink® (proximity ligation assay) PLA to amplify your protein signals by 1000x and allow you to visually detect proteins and their interactions, all within a native cell. Our straightforward method provides:

  • Visual protein interactions – both stable and transient
  • Endogenous protein detection – no overexpression or genetic manipulation
  • High specificity – use of two antibodies/probes eliminates false positives
  • Single molecule sensitivity – rolling circle amplification makes proteins visible
  • No special equipment needed – standard immunofluorescence methods
  • Publication-ready results – compare image results from indirect methods (Co-Ip/WB)

Uncover the opportunities in your protein detection research with amplified performance and visual results.

 How does Duolink® PLA work?

 Protein Detection Resources

Duolink® PLA Resource center


  • Protein-Protein Interaction
  • Post-Translational Modification
  • Low Abundant Proteins
  • Protein Localization
  • Digital Quantification

Product Search
Product Search

Ready to begin your experiment? View our
list of Duolink® PLA products to get started.

Primary Antibodies
Primary Antibodies

Explore our selection of PLA-qualified primary antibodies to use in your next Duolink® assay.