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Bioactive Small Molecules Literature References

Cell Biology Applications Center

Bioactive Small Molecules Literature References

Bioactivity. Sigma® has a broad range of Bioactive Small Molecules

Looking for current application references for Bioactive Small Molecules? Look no further!

Apoptosis Publications:
Click on the title to view the abstract on PubMed.

Title Author / Journal Product Cited
The retinoblastoma protein regulates pericentric heterochromatin.
Isaac, C.E., et al.
Mol Cell Biol, 2006; 3659-71.
Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton.
Mayanagi, T., et al.
J Biol Chem, 2008; 31183-96.
Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.
Oestreich, E.A., et al.
J Biol Chem, 2009; 1514-22.
Multiphasic and tissue-specific roles of sonic hedgehog in cloacal septation and external genitalia development.
Seifert, A.W., et al.
Development, 2008; 3949-57.
Inhibition of oligodendrocyte apoptosis by sublytic C5b-9 is associated with enhanced synthesis of bcl-2 and mediated by inhibition of caspase-3 activation.
Soane, L., et al.
J Immunol, 2008; 6132-8.
Effects of chemotherapeutic agents on the function of primary human osteoblast-like cells derived from children.
Davies, J.H., et al.
J Clin Endocrinol Metab, 2003; 6088-97.
Inhibition of human p53 basal transcription by down-regulation of protein kinase Cdelta.
Abbas, T., et al.
J Biol Chem, 2004; 9970-7.
Effects of quercetin on the pharmacokinetics of Etoposide after oral or intravenous administration of etoposide in rats.
Li, X., et al.
Anticancer Res, 2009; 1411-5.
Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo.
Humphries, M.J., et al.
J Biol Chem, 2005; 9728-37.
A0781, E1383
Overexpression of Eg5 causes genomic instability and tumor formation in mice.
Castillo, A., et al.
Cancer Res, 2007; 10138-47.
Mechanics of cell spreading: role of myosin II.
Wakatsuki, T., et al.
J Cell Sci, 2003; 1617-25.
Epigenetic programming of the rRNA promoter by MBD3.
Brown, S.E., et al.
Mol Cell Biol, 2007; 4938-52.
Nuclear corepressor is required for inhibition of phosphoenolpyruvate carboxykinase expression by tumor necrosis factor-alpha.
Yan, J., et al.
Mol Endocrinol, 2007; 1630-41.
A functional link between rhythmic changes in chromatin structure and the Arabidopsis biological clock.
Perales, M,., et al.
Plant Cell, 2005; 2111-23.
Direct and indirect regulation of cytokine and cell cycle proteins by EBNA-2 during Epstein-Barr virus infection.
Spender, L.C., et al.
J Virol, 2001; 3537-46.
14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation.
Choi, S.J,., et al.
Nucleic Acids Res, 2001; 2836-42.
Valproic acid, trichostatin and their combination with hemin preferentially enhance gamma-globin gene expression in human erythroid liquid cultures.
Marianna, P., et al.
Haematologica, 2001; 700-5.
Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5.
Zhang, Z.K., et al.
Mol Cell Biol, 2002; 5975-88.
Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility.
Davis, F.J., et al.
Am J Physiol Heart Circ Physiol, 2008; H1477-90.
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.
Condliffe, A.M., et al.
Blood, 2005; 1432-40.
Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone.
Murphy, P.J., et al.
J Biol Chem, 2005; 33792-9.
Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.
Chang, C.W., et al.
Mol Cell Biol, 2005; 8401-14.
Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis.
Xu, C.R., et al.
Proc Natl Acad Sci U S A, 2005; 14469-74.
Histone deacetylase inhibitor pharmacodynamic analysis by multiparameter flow cytometry.
Chung, E.J., et al.
Ann Clin Lab Sci, 2005; 397-406.
Analysis of the transcription factor WUSCHEL and its functional homologue in Antirrhinum reveals a potential mechanism for their roles in meristem maintenance.
Kieffer, M., et al.
Plant Cell, 2006; 560-73.
Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications.
Guan, M., et al.
Clin Cancer Res, 2006; 1412-9.
Functional interplay between histone demethylase and deacetylase enzymes.
Lee, M.G., et al.
Mol Cell Biol, 2006; 6395-402.
Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer.
Camarero, N., et al.
Mol Cancer Res, 2006; 645-53.
Mapping of the juxtacentromeric heterochromatin-euchromatin frontier of human chromosome 21.
Grunau, C., et al.
Genome Res, 2006; 1198-207.
An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis.
Zhao, L.Y., et al.
Cancer Res, 2007; 9445-52.
Site-specific acetylation of p53 directs selective transcription complex assembly.
Roy, S., et al.
J Biol Chem, 2007; 4765-71.
Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing.
Shimazu, T., et al.
J Biol Chem, 2007; 4470-8.
The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3.
Liu, C., et al.
Cancer Res, 2007; 2626-31.
Beryllium induces premature senescence in human fibroblasts.
Coates, S.S., et al.
J Pharmacol Exp Ther, 2009; J Pharmacol Exp Ther.
BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3.
Hishiki, T., et al.
J Biol Chem, 2007; 28335-43.
Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes.
Wang, J., et al.
J Biol Chem, 2007; 28408-18.
Regulation of aryl hydrocarbon receptor expression and function by glucocorticoids in mouse hepatoma cells.
Bielefeld, K.A., et al.
Drug Metab Dispos, 2008; 543-51.
Transcription of genes encoding synaptic vesicle proteins in human neural stem cells: chromatin accessibility, histone methylation pattern, and the essential role of rest.
Ekici, M., et al.
J Biol Chem, 2008; 9257-68.
HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity.
Gupta, M.P., et al.
J Biol Chem, 2008; 10135-46.
Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.
Maruyama, R., et al.
Carcinogenesis, 2007; 1312-8.
Multidrug resistance-associated protein-overexpressing teniposide-resistant human lymphomas undergo apoptosis by a tubulin-binding agent.
Aneja, R., et al.
Cancer Res, 2008; 1495-503.
Recruitment to the nuclear periphery can alter expression of genes in human cells.
Finlan, L.E., et al.
PLoS Genet, 2009; e1000039.
c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene.
Wolter, S., et al.
Mol Cell Biol, 2008; 4407-23.
Histone acetylation is recruited in consolidation as a molecular feature of stronger memories.
Federman, N., et al.
Learn Mem, 2009; 600-6.
Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6.
Gibbs, A., et al.
Proc Natl Acad Sci U S A, 2009; 16663-8.
Multifunctional role of Erk5 in multiple myeloma.
Carvajal-Vergara, X., et al.
Blood, 2006; 4492-9.
Netrin-1 is a survival factor during commissural neuron navigation.
Furne, C., et al.
Proc Natl Acad Sci U S A, 2008; 14465-70.
Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance.
Ho, J.D., et al.
Proc Natl Acad Sci U S A, 2008; 19383790.

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Kinase Phosphatase Biology Publications:
Click on the title to view the abstract on PubMed.

A Phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression.
Zhang, Q., et al.
J Biol Chem, 2006; 10174-81.
Neuroprotection by histone deacetylase-related protein.
Morrison, B.E., et al.
Mol Cell Biol, 2006; 3550-64.
HIV-1 latency in actively dividing human T cell lines.
Jeeninga, R.E., et al.
Retrovirology, 2008; 37.
Angiotensin II type 2 receptor agonist directly inhibits proximal tubule sodium pump activity in obese but not in lean Zucker rats.
Hakam, A.C., et al.
Hypertension, 2008; 1117-24.
Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells.
Pan, M.R., et al.
J Biol Chem, 1999; 11155-63.
Dedifferentiation of adult human myoblasts induced by ciliary neurotrophic factor in vitro.
Chen, X., et al.
Mol Biol Cell, 2005; 3140-51.
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells.
Hamazaki, T., et al.
Mol Cell Biol, 1995; 7539-49.
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment.
Kunath, T., et al.
Development, 2006; 2895-902.
Inhibition of glycogen synthase kinase-3beta is sufficient for airway smooth muscle hypertrophy.
Deng, H., et al.
J Biol Chem, 2008; 10198-207.
Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance.
Wolf, A.M., et al.
J Neurosci, 2008; 3456-67.
XIAP regulates cytosol-specific innate immunity to Listeria infection.
Bauler, L.D., et al.
PLoS Pathog, 2008; e1000142.
A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2.
Steinberg, R., et al.
J Biol Chem, 2007; 32288-97.
S5567, U120, S7067
Role of MAPK phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells.
Venugopal, S.K., et al.
J Biol Chem, 2007; 31900-8.
S5567, U120, S7067
Structural inference of native and partially folded RNA by high-throughput contact mapping.
Das, R., et al.
Proc Natl Acad Sci U S A, 2008; 4144-9.
S5567, U120, S7067
The role of RIP2 in p38 MAPK activation in the stressed heart.
Jacquet, S., et al.
J Biol Chem, 2008; 11964-71.
TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype.
Sainson, R.C., et al.
Blood, 2008; 4997-5007.
Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells.
Chen, L.Y., et al.
Am J Physiol Lung Cell Mol Physiol, 2008; L326-35.
Divergent transforming growth factor-beta signaling in hepatic stellate cells after liver injury: functional effects on ECE-1 regulation.
Khimji, A.K., et al.
Am J Pathol, 2008; 716-27.
Epigenetic programming of the rRNA promoter by MBD3.
Brown, S.E., et al.
Mol Cell Biol, 2007; 4938-52.
S8307, P215
Nuclear corepressor is required for inhibition of phosphoenolpyruvate carboxykinase expression by tumor necrosis factor-alpha.
Yan, J., et al.
Mol Endocrinol, 2007; 1630-41.
S8307, P215
A functional link between rhythmic changes in chromatin structure and the Arabidopsis biological clock.
Perales, M,., et al.
Plant Cell, 2005; 2111-23.
S8307, P215
Short-interfering RNA-mediated Lck knockdown results in augmented downstream T cell responses.
Methi, T., et al.
J Immunol, 2005; 7398-406.


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Neuroscience Publications:
Click on the title to view the abstract on PubMed.

A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis.
Sato, T., et al.
Proc Natl Acad Sci U S A, 2009; 1421-6.
Local suppression of Epstein-Barr virus (EBV)-specific cytotoxicity in biopsies of EBV-positive Hodgkin's disease.
Frisan, T., et al.
Blood, 2008; 1493-501.
Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts.
Svegliati, S., et al.
J Biol Chem, 2005; 36474-82.
Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor.
Deecher, D.C., et al.
J Pharmacol Exp Ther, 2006; 657-65.
Chronic fenfluramine administration increases plasma serotonin (5-hydroxytryptamine) to nontoxic levels.
Zolkowska, D., et al.
J Pharmacol Exp Ther, 2006.
Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells.
Accioly, MT., et al.
Cancer Res, 2008; 1732-40.
AQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18b.
Procino, G., et al.
J Cell Sci, 2008; 2097-106.
Influenza virus and poly(I:C) inhibit MHC class I-restricted presentation of cell-associated antigens derived from infected dead cells captured by human dendritic cells.
Frleta, D., et al.
J Immunol, 2009; 2766-76.
Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia.
Miraucourt, LS., et al.
J Neurosci, 2005; 2519-27.
Na+/H+ exchange inhibition in hypertrophied myocardium subjected to cardioplegic arrest: an effective cardioprotective approach.
Kevelaitis, E., et al.
Eur J Cardiothorac Surg, 2005; 111-6.
The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential anti-tumor target for psychotropics.
Meredith, E.J., et al.
FASEB J, 2005; 1187-9.
F132, H9523
Characterization of single channel currents from primary cilia of renal epithelial cells.
Raychowdhury, M.K., et al.
J Biol Chem, 2007; 34718-22.
F132, H9523
Intra-amygdaloid injection of kainic acid in rats with genetic absence epilepsy: the relationship of typical absence epilepsy and temporal lobe epilepsy.
Gurbanova, A.A., et al.
J Neurosci, 2008; 7828-36.
Sex differences in caspase activation after stroke.
Liu, F., et al.
Stroke, 2009; 1842-8.
Global gene expression analysis reveals a role for the alpha 1 integrin in renal pathogenesis.
Sampson, N.S., et al.
J Biol Chem, 2001; 34182-8.
Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia.
Medvedeva, Y.V., et al.
J Neurosci, 2009; 1105-14.
Binding and crosslinking of 125I-labeled recombinant human tumor necrosis factor to cell surface receptors.
Yoshie, O., et al.
J Biochem, 1986; 531-41.
Soluble expression of recombinant human secondary lymphoid chemokine (SLC) in E. coli and research on its in vitro and in vivo bioactivity.
Chun, L., et al.
J Biochem, 2004; 769-76.
Cytosolic stress reduces degradation of connexin43 internalized from the cell surface and enhances gap junction formation and function.
VanSlyke, J.K., et al.
Mol Biol Cell, 2005; 5247-57.
Electroporation-based methods for in vivo, whole mount and primary culture analysis of zebrafish brain development.
Hendricks, M., et al.
Neural Dev, 2006; 6.
International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states.
Jensen, R.T., et al.
Pharmacol Rev, 2005; 1-42.


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