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Bile Acid Metabolism

Mammalian cells use multiple biochemical pathways to break down cholesterol into more polar, water-soluble bile acids that can function as emulsifying agents. A series of enzymatic reaction steps involving 7a-hydroxylations, epimerization of the 3ß-hydroxy group, saturation of the double bond, and side-chain cleavage or oxidation convert cholesterol into the bile acid chenodeoxycholic acid. 7-Deoxycholic acid is formed along a similar pathway, with an
additional 12a-hydroxylation and removal of the 7-hydroxy group. The hydrophobic/hydrophilic balance of the various bile acids facilitate the solubilization of monoacylglycerols, fat-soluble vitamins, and other lipids. This helps digestion and absorption but is also required for solubilization and excretion of lipophilic metabolites such as bilirubin.

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H1015 25-Hydroxycholesterol ≥98% 25-Hydroxycholesterol is a side-chain oxysterol that reportedly triggers activation of a number of cholesterol molecules. This triggers their movement from cell membrane to the endoplasmic reticulum (ER). 25-Hydroxycholesterol affects the immune system and has a key role in the pathogenesis of atherosclerosis.
G2878 Glycocholic acid hydrate synthetic, ≥97% (HPLC) Bile Acid
30968 Sodium deoxycholate monohydrate BioUltra, ≥99.0% (NT) Bile salt
G0759 Sodium glycochenodeoxycholate ≥97% (HPLC)  
T6260 Sodium taurochenodeoxycholate  
T9034 Taurocholic acid sodium salt hydrate BioXtra, ≥95% (TLC) Non-sulfated bile salt, physiological transport substrate for the bile salt export pump/sister of Pgp (BSEP/spgp), Na(+)/taurocholate cotransporter (NTCP) and MRP3 into the hepatic carnalicular.
U5127 Ursodeoxycholic acid ≥99%