Insulin acts on hepatocyte cells to supress gluconeogenesis, the metabolic pathway that generates glucose from non-carbohydrate sources. In insulin-resistant tissues, insulin induces triglyceride synthesis but fails to suppress gluconeogenesis resulting in chronically elevated blood glucose levels. Enzymes of the gluconeogenic pathway are attractive targets for pharmacological intervention in insulin-resistant and diabetic patients.

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E6126 Enolase from baker's yeast (S. cerevisiae) lyophilized powder, ≥50 units/mg protein
G5758 Glucose-6-Phosphatase from rabbit liver ≥0.05 units/mg protein, Protein ~30 % (balance mostly sucrose)
G5537 Glyceraldehyde-3-phosphate Dehydrogenase from baker's yeast (S. cerevisiae) lyophilized powder, 70-140 units/mg protein
G6019 Glyceraldehyde-3-phosphate Dehydrogenase from human erythrocytes lyophilized powder, 50-150 units/mg protein
G2267 Glyceraldehyde-3-phosphate Dehydrogenase from rabbit muscle lyophilized powder, ≥75 units/mg protein
N4773 Neuron-specific enolase from human brain ≥95% (SDS-PAGE), buffered aqueous solution
P7634 3-Phosphoglyceric Phosphokinase from baker's yeast (S. cerevisiae) ammonium sulfate suspension, ≥1000 units/mg protein
P7173 Pyruvate Carboxylase from bovine liver buffered aqueous glycerol solution, 5-25 units/mg protein (BCA)
11161 Sodium (R)-β-hydroxyisobutyrate ≥96.0%
16842 Sodium (S)-β-hydroxyisobutyrate ≥96.0%
36105 (±)-Sodium β-hydroxyisobutyrate ≥96.0%