Isocitrate Dehydrogenase (IDH) in Cancer Metabolism

Isocitrate dehydrogenase (IDH) catalyzes the conversion of isocitrate to a-ketoglutarate. In eukaryotes, there are three isozymes of IDH, the mitochondrial IDH2 and IDH3, and the cytoplasmic/peroxisomal IDH1. IDH1 and IDH2 mutations resulting in neomorphic enzymatic activity are found in certain cancers such as glioblastoma, acute myeloid leukemia, and colon cancer. This neoactivity shows a change in the substrate specificity resulting in the conversion of a-ketoglutarate to 2-hydroxyglutarate.

Antibodies Against Proteins Involved in the IDH Pathway

Product #

Description

Clone

Form

Gene Symbol (ID)

Species Reactivity

Application

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HPA044341 Anti-CIC antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CIC(23152)
human
IF, IHC
HPA035248 Anti-IDH1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... IDH1(3417)
human, mouse, rat
IHC
AMAB90578 Monoclonal Anti-IDH1 antibody produced in mouse CL0219, monoclonal
purified immunoglobulin
human ... IDH1(3417)
human
IF, IHC
HPA007831 Anti-IDH2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... IDH2(3418)
rat, human, mouse
IF, IHC
WH0003418M1 Monoclonal Anti-IDH2 antibody produced in mouse 5F11, monoclonal
purified immunoglobulin
human ... IDH2(3418)
human
ELISA (i), IHC (p), WB
HPA019032 Anti-TET1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... TET1(80312)
human
IF, IHC
SAB2501479 Anti-TET2 antibody produced in goat polyclonal
affinity isolated antibody
human ... TET2(54790)
bovine, human, canine, mouse, rabbit
ELISA (i), IHC
HPA050845 Anti-TET3 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... TET3(200424)
human
IF, IHC

Assay Kits for Studying Isocitrate Dehydrogenase (IDH) Activity

Product #

Description

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MAK062 IDH Activity Assay Kit sufficient for 100 colorimetric tests
MAK061 Isocitrate Assay Kit sufficient for 100 colorimetric tests
MAK054 α-Ketoglutarate Assay Kit sufficient for 100 colorimetric or fluorometric tests

Gene Editing Tools For Studying the IDH Pathway

Product #

Product Name

Gene Symbol (ID)

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EHU110401 MISSION® esiRNA esiRNA human IDH1 (esiRNA1) human ... IDH1(3417)
EHU024791 MISSION® esiRNA esiRNA human TET2 (esiRNA1) human ... TET2(54790)
EHU097551 MISSION® esiRNA esiRNA human TET3 (esiRNA1) human ... TET3(200424)
EHU124501 MISSION® esiRNA esiRNA human TET3 (esiRNA2) human ... TET3(200424)
EHU053891 MISSION® esiRNA esiRNA human TET1 (esiRNA1) human ... TET1(80312)
EHU057381 MISSION® esiRNA esiRNA human CIC (esiRNA1) human ... CIC(23152)

Isocitrate Dehydrogenase (IDH) Proteins

Product #

Description

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I2411 Isocitrate Dehydrogenase 1 (NADP+) human recombinant, expressed in Sf9 cells, ≥90% (SDS-PAGE)

Isocitrate Dehydrogenase (IDH) Substrates and Reaction Products

Product #

Description

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H8378 D-α-Hydroxyglutaric acid disodium salt ≥95% (GC)
90790 L-α-Hydroxyglutaric acid disodium salt ≥98.0% (GC)
I1252 DL-Isocitric acid trisodium salt hydrate ≥93%
K2010 α-Ketoglutaric acid sodium salt BioUltra
58790 (+)-Potassium Ds-threo-isocitrate monobasic ≥98.0% (NT)