Phytochemicals in Herbal Medicine or Traditional Chinese Medicine (TCM)

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SMB00346 Alisol B acetate ≥98% (HPLC) Alisol B acetate is a triterpene from Rhizoma Alismatis (rhizomes of Alisma plantago-aquatica). It induces apoptosis in human prostate cancer cells.
SMB00336 Aristolochic acid B ≥97% (HPLC) Aristolochic acid B inhibits in vitro phospholipid hydrolysis by HSF-PLA2 in a dose-dependent manner.
A1010 Arsenic(III) oxide ReagentPlus®, ≥99.0% Very potent agent against acute promyelocytic leukemia (APL). Causes skin, lung and bladder cancer.
A9361 Artemether ≥98% (HPLC) Artemether is a methyl ether derivative of artemisinin. It is used against multi-drug resistant strains of the malaria parasite, Plasmodium falciparum, and shows potential in treatment of schistosomiasis.
Artemisinin possesses a highly reactive endoperoxide bridge, which is core for its therapeutic potential. The endoperoxide bond reacts with iron in the erythrocytes with malarial parasite. This leads to the generation of reactive oxygen species (ROS) directly targeting the parasite. Artemisinin also regulates ferroptosis in tumor cells. The α cell transcription factor Arx expression is reduced by artemether. Prolonged exposure of primary islets also resulted in loss if identity in endocrine cell types and their functionality.
361593 Artemisinin 98% Artemisinin (Qinghaosu), a sesquiterpene lactone, is a highly active anti-malarial (falciparum malaria) drug. Artemisinin is also an anthelmintic (parasitic worm) effective against the blood fluke, schistosomiasis.
A3731 Artesunate from Artemisia annua Artesunate acts on the electron transport chain, generates local reactive oxygen species, and causes the depolarization of the mitochondrial membrane. It inhibits TNFα-induced production of proinflammatory cytokines via inhibition of NF-κB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes.
A2612 Asiatic acid ≥98% (HPLC), from Centella asiatica Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties.
A2862 Astilbin from Engelhardtia roxburghiana ≥98% Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations. Immunosuppresive. Antiproliferative.
SMB00318 Astragaloside I ≥97% (HPLC) Astragaloside I has been shown to increase gastric pH without changing gastric volume or acid output.
SMB00316 Astragaloside II ≥92% (HPLC) Astragaloside II stimulates osteoblast differentiation resulting in bone formation.
SMB00317 Astragaloside III ≥96% (HPLC)  
A2737 Atractylenolide I ≥98% (HPLC) Phytochemical from Traditional Chinese Medicine herbal preparations. Atractylenolide I is an anti-inflammatory that is reported to inhibit angiogenesis.
A2987 Atractylenolide III ≥98% (HPLC) Atractylenolide III possesses anti-inflammatory and anticancer properties.
B0261 Bufalin Bufalin is an anti-metastasis drug, which elicits anti-tumor functionality by favoring cell cycle arrest and apoptosis in various cancer types including hepatocellular, bladder and osteosarcoma. It also promotes autophagic cell death and possesses anti-inflammatory properties. Bufalin is a steroid receptor coactivator (SRC) inhibitor.
SMB00312 3-N-Butylphthalide ≥98% (HPLC)  
B9938 Calycosin ≥98% (HPLC) Isoflavone and phytoestrogen isolated froma traditional Chinese medicinal herb. Calycosin induces angiogenesis in HUVEC and promotes proliferation of estrogen-receptor positive cells in vivo and in vitro. Also functions as a vasorelaxant on rat thoracic aorta.
C9911 (S)-(+)-Camptothecin ≥90% (HPLC), powder (S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.
C7632 Cantharidin Inhibitor of protein phosphatase 2A.
B0189 Casticin from Vitex trifolia, ≥98% (HPLC) Tubulin-binding anticancer flavonoid. Casticin induces apoptosis in cancer cells.
SMB00376 CDDO Methyl Ester ≥98% (HPLC) CDDO-Me inhibits inflammatory mediators including IL-6, IL-10, and IL-12. It enhances apoptosis induced by TNF and chemotherapeutic agents. CDDO-Me exhibits anti-proliferative activity in osteosarcoma cells and enhances the effectiveness of chemotherapeutic agents by inducing an intrinsic mitochondrial-dependent apoptotic pathway. It can be used as an adjuvant treatment for advanced and fatal form of prostate cancer.
C0869 Celastrol ≥98% (HPLC), solid Celastrol is a potent antioxidant, and anti-inflammatory agent. It is a novel HSP90 inhibitor (disrupts Hsp90/Cdc37 complex), that exhibits anticancer (anti-angiogenic - suppresses VEGFR expression); antioxidant (inhibits lipid peroxidation) and anti-inflammatory activity (suppresses iNOS and inflammatory cytokine production).
Celastrol is a quinone methide triterpene naturally present in Tripterygium wilfordii. It is useful in treating rheumatoid arthritis. Celastrol prevents the action of proteasome and nuclear factor Κb.
SMB00314 Coptisine Chloride ≥98% (HPLC)  
G0424 Corilagin Corilagin is a polyphenol, specifically a hydrolyzable tannin, found in Traditional Chinese Medicine herbal preparations. It is reported to have anti-inflammatory and anti-tumor activities.
G0549 Corosolic acid from Lagerstroemia speciosa ≥98% (HPLC) Triterpene phytochemical found in medicinal herbal extracts. Possesses antiatherosclerotic, antihyperlipidemic, antioxidant, antiinflammatory, antifungal, antiviral and antineoplastic activities.
SMB00322 Crotonoside ≥95% (HPLC) Crotonoside, or isoguanosine, is a naturally occurring active isomer of guanosine that is found in the seeds of Croton tiglium, which is used in Traditional Chinese Medicine. It has shown more activity than adenosine in reducing the blood pressure of rabbits and cats.
C7727 Curcumin ≥94% (curcuminoid content), ≥80% (Curcumin) A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
SMB00350 Dehydroandrographolide ≥98% (HPLC) Dehydroandrographolide possesses activity against hepatitis B virus DNA replication.
D7439 Dihydroartemisinin analytical standard, mixture of α and β isomers  
D0947 Dihydrotanshinone I ≥98% (HPLC) Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with mouse xenograft model.
D7321 Diosmetin Flavonoid from Citrus limon. Antioxidant. Inhibits carcinogen activation by inhibiting the CYP1A1 enzyme.
SMB00445 Ganoderic acid A ≥98% (HPLC) Ganoderic Acid is reported to exhibit anti-tumor activity mediated through its inhibitory effect on NFKB and AP-1 as well as antimetastasis and anti-HIV activities.
SMB00313 Gastrodin ≥98% (HPLC) Gastrodin can penetrate through the blood-brain barrier and has been suggested to have neuroprotective effects against hypoxia. It is also known to reduce the immunoreactivity of gamma-aminobutyric acid shunt enzymes in hippocampal tissues. Traditionally, gastrodin is also known to be effective in the treatment of headache, vertigo, dizziness and convulsive disorders. Along with anticonvulsant property, it also possesses antiepileptic, anxiolytic, anti-inflammatory and antiobesity action. Gastrodin is also helps in learning and memory stimulation.
H35803 2′-Hydroxy-4′-methoxyacetophenone 99%  
I1286 Icariin ≥94% (HPLC) Flavonoid glucoside derived from the the Epimedium plant genus. This pharmacologically active constituent or its derivatives have been shown to enhance bone formation, modulate multidrug resistance, enhance neuronal viability, stimulate angiogenesis, and exhibit antioxidant activity.
SML0280 (2′Z)-Indirubin ≥98% (HPLC) Indirubin is an inhibitor of GSK-3β and of cyclin-dependent kinases (CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p35). Also, indirubin is a specific Aryl Hydrocarbon receptor (AHR) ligand.
I3766 Isoliquiritigenin powder Isoliquiritigenin is a soluble guanylyl cyclase activator and possesses antitumor activity. It also possesses antioxidant, antiplatelet and estrogenic properties.
I1536 Isoorientin ≥98% (HPLC) C-glycosyl flavone with anti-inflammatory, antimicrobial and antioxidant properties. Induces antioxidant response through PI3K singaling.
SMB00434 Jujuboside A ≥97% (HPLC) Jujuboside A has been shown to be a major hypnotic-sedative and is used for treating insomnia and anxiety.
SMB00451 Jujuboside B ≥98% (HPLC) Jujuboside B is known for its treatment of insomnia and anxiety and has been reported to have activities relevant to the cardiovascular system. Jujuboside B inhibits platelet aggregation and is considered as a preventive drug for platelet-based cardiovascular diseases.
Jujuboside B as food supplement, has neurobeneficial effects and could be a potential drug candidate for treating neurodegenerative diseases.
L8045 Liquiritin from Glycyrrhizae root (licorice root), ≥98% (HPLC)  
L9283 Luteolin ≥98% (TLC), powder Hydroxylated flavone derivative, a strong antioxidant and radical scavenger. Suggested to play a role in prevention of cancer, possibly via the inhibition of fatty acid synthase activity.
M6949 Madecassoside from Centella asiatica ≥95% (HPLC) Madecassoside is a triterpenoid compound found in Centella asiatica (Gotu kola), a medicinal herb used in traditional Chinese medicine (TCM), Ayurvedic medicine, and traditional African medicine. Madecassoside has a wide range of reported biological activities including, anti-inflammatory, wound healing, and anti-oxidant activities. It has been reported to suppress LPS-induced TNF-alpha production via inhibition of ERK, p38, and NF-kappaB activity.
M3824 α-Mangostin ≥98% (HPLC) Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis via the mitochondrial pathway, reduce cell proliferation and inhibit tumorigenesis.
M6699 Maslinic acid ≥98% (HPLC) Predominant triterpenoid found in olives. Anti-proliferative. Promising chemopreventive agent.
M5319 Matrine Matrine is an alkaloid that is one of the major components in the root of the saphoro plant. Matrine has been studied for possible antiviral efficacy against hepatitis B and C, as well as impact against some skin diseases and forms of cancer.
SMB00319 Mesaconitine ≥97% (HPLC)  
N3915 Notoginsenoside R1 ≥98% (HPLC) Notoginsenoside R1 has been shown to exhibit antooxidant, anti-inflammatory, antiapoptotic, and immune-stimulatory properties.
O9639 Oridonin ≥98% (HPLC), solid Oridonin has potent anti-tumor activity. Oridonin targets AE (AML1-ETO) oncoprotein. Exposure to oridonin induces apoptosis in AE-bearing leukemic cells through the activation of intrinsic apoptotic pathway and triggering a caspase-3-mediated degradation of AE at D188. The compound also prolonged the lifespan of C57 mice bearing truncated AE-expressing leukemic cells without side effects like suppression of bone marrow or reduction of body weight of animals, and exerted synergic effects while combined with cytosine arabinoside. Additionally, oridonin inhibited tumor growth in nude mice inoculated with t(8;21)-harboring Kasumi-1 cells.
SMB00446 Peimine ≥98% (HPLC) Peimine is a known MAPK inhibitor, as well as an inhibitor of p38, ERK and JNK phosphorylation, and NFκB activation. Peimine shows antitussive, expectorant and anti-inflammatory effects in vivo.
G9923 Picroside I ≥98% (HPLC) Phytochemical found within a Traditional Chinese Medicine herbal preparation. Picroside I, an iridoid glycoside, is a hepatoprotective agent.
G0174 Picroside II Phytochemical found in Traditional Chinese Medicine herbal preparations. Picroside II, a glucoside, is reported to have hepatoprotective, cardioprotective, and neuroprotective properties.
SMB00436 Pinoresinol diglucoside ≥98% (HPLC) Pinoresinol diglucoside has antihypertensive properties. It serves as a α-glucosidase inhibitor. α-Glucosidase catalyzes the conversion of carbohydrates to glucose in the small intestine. Hence, pinoresinol diglucoside might be useful as an antidiabetic agent.
P0020 Pristimerin More active than euphol against MGL, better activity with rat neurons, but less selective relative to similar enzymes. First MGL inhibitor to act reversibly, several others covalently bind to cysteine residues. Other studies involve multiply mylome, pristimerin inhibits NF-κB activation via inhibition of IKK-α or IKK-β. It is the methyl ester of celastrol (C0869).
G0299 Protodioscin from Dioscorea spp., ≥98% (HPLC) Saponin phytochemical found in asparagus. Cardioprotective and anti-hyperlipidemic agent. Cytotoxic effect against human cancer cell lines.
H9416 Pseudohypericin ≥95% (HPLC) One of the major bioactive constituents of St. John′s wort (Hypericum perforatum). Implicated in the antidepressant efficacy of St. John′s wort.
L8170 Pseudolaric Acid B ≥98% (HPLC) Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi. It has shown antifungal, antifertility, and antiangiogenic properties. It also may exihibit anti-cancer and anti-inflammatory properties.
P0023 Punicalagin ≥98% (HPLC), from pomegranate Potent immune suppressant isolated from pomegranate.
SMB00428 Resibufogenin ≥98% (HPLC) Resibufogenin is a specific sodium/potassium-ATPase protein (Na+/K+-ATPase) inhibitor.
R7269 Rhein Constituent that is enriched in rhubarb with anti-inflammatory, anti-osteoarthritic, and anti-cancer activity. It reduces IL-1β production and secretion, caspase-3 activity, inducible nitric oxide synthase activity, and phosphorylation of c-Jun and c-Jun NH2-terminal kinase (JNK).
R4033 Rosmarinic acid ≥98% (HPLC), from Rosemarinus officinalis L. Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive performance, Alzheimer′s disease prevention, kideney disease treatment, cardioprotection and cancer chemoprevention.
SMB00295 Ruscogenin ≥98% (HPLC) Ruscogenin inhibits the expressions of TF, iNOS, and NF-kappaB p65 and is therefore a potential target for acute lung injury or sepsis.
SMB00368 Schisandrin A ≥98% (HPLC) Schisandrin A is a bioactive lignan found in the fruits of several species of the Schisandra genus that has liver-protective, anti-tumor and antioxidant activities. It increases the activity of superoxide dismutase and glutathione peroxidase and shows anti-ischemic effects in vivo.
SMB00379 Schisantherin A ≥98% (HPLC) Schisantherin A is a lignan isolated from the fruits of Schisandra chinesi.
Schisantherin A is a mechanism-based inhibitor that competitively inhibits and irreversibly inactivates CYP3A4.
Schisantherin A (StA) has neuroprotective activity and could be potential candidate for the treatment of neuron loss in neurodegenerative diseases including Parkinson’s disease. It inhibits tumor progression and could be a potential drug target for cancer treatment. StA blocks ATP-binding cassette transporters and restores the levels of anti-cancer drugs in cancer cells. It also has anti-inflammatory property.
S0327 Scutellarein ≥98% (HPLC) Flavonoid that is selectively cytotoxic toward cancer cells. Induces mitochondrial ROS, DNA damage, and metabolic suppression, preferentially in tumor cells. Scutellarein has been shown to have better absorption than scutellarin in Caco-2 monolayer cells.
S0202 Secoisolariciresinol diglucoside ≥97% (HPLC) Secoisolariciresinol diglucoside is a phytochemical present in flax, sunflower, sesame and pumpkin seeds. It is a precursor of mammal lignans and a phytoestrogen. Secoisolariciresinol diglucoside has been shown to have antioxidant and cardioprotective properties.
S7576 Shikonin ≥98% (HPLC) Naphthoquinone isolated from Arnebia sp. Used as an anti-inflammatory treatment in traditional chinese medicine (TCM). Inhibits chemokine receptor function and suppresses HIV-1.† Circumvents cancer drug resistance by induction of cell death through a necroptotic pathway.† Treatment of cancer cells with shikonin suppressed glycolysis via the inhibition of pyruvate kinase M2 (PKM2).
SMB00545 Skullcapflavone II ≥90% (LC/MS-UV)  
S3757 α-Solanine from potato sprouts, ≥95%  
SMB00438 Sophoricoside ≥98% (HPLC) Sophoricoside has numerous pharmacological effects including anti-inflammatory, anti-cancer and immunosuppressive activities.
S9951 Soyasaponin I Antioxidant and anti-inflammatory saponin found in soybean. Attenuates TNBS-induced colitis in mice. The structure consists of a glycoside moiety and triterpene derivative. Sialytransferase inhibitor and renin inhibitor.
SMB00452 Tabersonine ≥95% (HPLC) Tabersonine shows hypotensive, anti-tumor, hypoglycemic, and diuretic activity.
T5330 Tanshinone I ≥98% (HPLC) Phenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Modulates or prevents breast cancer metastasis by regulating adhesion molecules. Anti-inflammatory.
T4952 Tanshinone IIA ≥97% (HPLC) Phenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Anti-inflammatory. Antioxidant. Cytotoxic against a variety of cell lines, inlcuding human glioma cells.
SMB00370 Tetrahydrocurcumin ≥96% (HPLC) Tetrahydrocurcumin is being studied for the treatment of cancer and dementia. It has antioxidant and anti-inflammatory properties. Tetrahydrocurcumin has been shown to have protective effects against diabetes and vascular dysfunction via alleviation of oxidative stress.
SMB00339 (-)-Tetrahydropalmatine ≥98% (HPLC) Tetrahydropalmatine is a potent muscle relaxant and has shown analgesic effects. Tetrahydropalmatine is known to help in the recovery of cocaine addiction, as it is an antagonist of dopamine (DA) D1 and D2 receptor.
T3652 Triptolide from Tripterygium wilfordii, ≥98% (HPLC), solid Triptolide is a diterpene triepoxide, the principal active ingredient in extracts from the Chinese herb Tripterygium wilfordii hook (TwHF). It is a potent immunosuppressant and anti-inflammatory. Triptolide has been shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. It synergizes with cyclosporin A in promoting graft survival in animal models and in suppression of graft versus host disease in allogeneic bone marrow transplants. In addition, it induces apoptosis in tumor cells and potentiates tumor necrosis factor (TNFα) induction of apoptosis in part through the suppression of c-IAP2 and c-IAP1 induction.
SMB00325 Triptonide ≥98% (HPLC) Triptonide has potent antileukemic and antitumor activities.
W0769 Wogonin hydrate ≥98% (HPLC), solid Wogonin co-treatment enhances apoptosis and antitumor potential of chemotherapeutic drug, oxaliplatin in gastric cancer cells. It also improves the efficacy of fluorouracil and paclitaxel. Wogonin anti-oxidative functionality may be useful in treating neurodegenerative and inflammatory diseases.
Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC50 = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction.
Z3902 Zerumbone ≥98% (HPLC) Zerumbone is a TRAIL-induced apoptosis potentiator. It potentiates TRAIL-induced apoptosis through the up-regulation of DR4 and DR5 expression and the down-regulation of cFLIP. Zerumbone has very little or no cytotoxic effect on the normal human endothelial cells and dermal fibroblasts. Zerumbone is a sesquiterpene isolated from in Zingiber zerumbet Smith (wild ginger).