ALK (receptor tyrosine kinase anaplastic lymphoma kinase)

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SML1304 KRCA-0008 ≥98% (HPLC) KRCA-0008 is a potent and selective ALK (aplastic lymphoma kinase) and Ack1 inhibitor that exhibits in vivo efficacy in xenograft mice model. KRCA-0008 potently inhibits ALK mutants L1196M, C1156Y, F1174L and R1275Q.
PZ0221 PF-06439015 methanesulfonate salt ≥98% (HPLC) PF-06439015 is a potent and selective inihibitor that overcomes clinical ALK (receptor tyrosine kinase anaplastic lymphoma kinase) mutations resistant to Crizotinib. PF-06439015 is potent across a broad panel of ALK mutant cell lines with an IC50 of 6.6 nM for tumor growth inhibition in a crizotinib-resistant cell line (H3122-L1196M).
PZ0271 PF-06463922 acetate ≥98% (HPLC) PF-06463922 is a potent, selective brain-penetrable inhibitor of both anaplastic lymphoma kinase (ALK) and c-ros Oncogene 1 (ROS1) with strong activity against all known ALK and ROS1 mutants identified in patients with crizotinib-resistant disease. PF-06463922 is in clinical trials for the treatment of non–small cell lung cancer (NSCLC).