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D101 (±)-DOI hydrochloride ≥98% (HPLC), solid (±)-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.
H2O: 10 mg/mL
ethanol: 2 mg/mL
D153 (R)(−)-DOI hydrochloride ≥98% (HPLC), solid Potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier; more potent enantiomer of ±-DOI hydrochloride.
H2O: ≥20 mg/mL
ethanol: soluble
125180 1-(3-Chlorophenyl)piperazine hydrochloride 99% 1-(3-Chlorophenyl)piperazine induces hypophagia in food-deprived and freely feeding rats. CPP has affinity for 11 neurotransmitter receptor binding sites in human brain membranes.
5-HT2c serotonin receptor agonist; metabolite of trazodone.
methanol: soluble
S006 Ketanserin (+)-tartrate salt ≥97%, solid Selective 5-HT2 serotonin receptor antagonist. Ketanserin significantly reduces nicotine self-administration in rats, supporting an unexpected involvement of serotonin in nicotine addiction.
0.1 M HCl: 6 mg/mL (lit.)(lit.)
DMSO: 52 mg/mL (lit.)(lit.)
ethanol: 3 mg/mL
P126 Pirenperone >97%, solid 5-HT2 serotonin receptor antagonist.
0.1 M HCl: 11 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 5.0 mg/mL
methanol: 2.5 mg/mL
C238 S(−)-Cyanopindolol hemifumarate salt solid, ≥98% (HPLC) 5-HT1A/1B serotonin receptor antagonist; β3-adrenoceptor antagonist.
DMSO: >10 mg/mL
S8061 SB 242084 dihydrochloride hydrate ≥98% (HPLC), powder SB 242084 is a potent and selective antagonist of 5-HT2C receptor. It increases the basal activity of dopaminergic neurons and affects the behavioral responses mediated by 5-HT2C such as mesolimbic neuron activity and food intake.3,4,5
DMSO: 15 mg/mL, clear
H2O: 5 mg/mL, clear
S180 SB-206553 hydrochloride hydrate ≥98% (HPLC), solid Potent 5-HT2B/5-HT2C serotonin receptor antagonist.
H2O: >10 mg/mL
M110 α-Methylserotonin maleate salt ≥98% (HPLC) 5-HT2 serotonin receptor agonist.
H2O: >3 mg/mL, clear (warmed)