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SML0844 GNF 5837 ≥98% (HPLC) GNF-5837 is an orally bioavailable Trk inhibitor (IC50 = 8 and 12 nM for TrkA and TrkB, respectively). GNF-5837 inhibits growth of Ba/F3 cells expressing Tel-Trl fusions. IC50 values for growth inhibition are Tel-TrkA = 11 nM, Tel-TrkB = 9 nM and Tel-TrkC = 7 nM.
G3420 GW441756 hydrochloride ≥97% (HPLC), powder, red Highly selective and potent TrkA kinase inhibitor. Orally active. IC50 = 2 nM
PZ0341 PF-06733804 ≥98% (HPLC) PF-06733804 is pan tropomyosin-related kinase (Trk) inhibitor.
PZ0340 PF-06737007 ≥98% (HPLC) PF-06737007 is pan tropomyosin-related kinase (Trk) inhibitor.
T2067 Tyrphostin AG 879 99% (HPLC) Inhibits the tyrosine kinase activity of the nerve growth factor receptor (TrkA; pp140trk) and heregulin receptor erbB-2 (HER-2).
Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells3. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice4.