Disintegrins

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E1518 Echistatin from Echis carinatus lyophilized powder, γ-irradiated, BioXtra Disintegrins represent a novel family of integrin β1 and β3 inhibitor proteins isolated from viper venoms. They are low molecular-weight, cysteine-rich peptides containing the Arg-Gly-Asp (RGD) sequence. They are the most potent known inhibitors of integrin function. Disintegrins interfere with cell adhesion to the extracellular matrix, including adhesion of melanoma cells and fibroblasts to fibronectin, and are potent inhibitors of platelet aggregation.
Echistatin has the ability to prevent IRS-1 (insulin receptor substrate-1) phosphorylation induced by IGF-1 (insulin like growth factor-1). Echistatin α1, purified from the venom of the saw scaled viper, Echis carinatus has the capability to block platelet aggregation.