Laminin Fragments

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PP69 β-Amyloid Peptide (1-42), Human  
171596 β-Amyloid Peptide (1-42), Rat Predominant peptide found in the brain of patients with Alzheimer's Disease and Down's Syndrome. Promotes down-regulation of Bcl-2 and upregulation of Bax expression in neurons.  
343781-M ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem A neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Primary Target
Voltage-activated N-type Ca2+ channels
Target IC50: 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors
C0668 Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg ≥90% (HPLC) Inhibits experimental metastasis.
C6171 Cys-Ser-Arg-Ala-Arg-Lys-Gln-Ala-Ala-Ser-Ile-Lys-Val-Ala-Val-Ser-Ala-Asp-Arg ≥90% (HPLC) Supports neurite outgrowth and stimulates neuronal-like process formation.
356310 Glyburide - CAS 10238-21-8 - Calbiochem A sulfonylurea that selectively blocks ATP-sensitive K+ channels. Cell permeable: no
Primary Target
ATP-sensitive K+ channels
Product does not compete with ATP.
Reversible: no
422682 K ir1.1 Inhibitor, VU591 - Calbiochem The Kir1.1 Inhibitor, VU591 controls the biological activity of Kir1.1. This small molecule/inhibitor is primarily used for Neuroscience applications.  
422689 Kir2.1 Inhibitor, ML133 - CAS 185669-79-8 - Calbiochem The Kir2.1 Inhibitor, ML133, also referenced under CAS 185669-79-8, controls the biological activity of Kir2.1. This small molecule/inhibitor is primarily used for Cancer applications.  
420336-M KB-R7943 - CAS 182004-65-5 - Calbiochem Primary Target
Na+/Ca2+ exchangers
Target IC50: 4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively
454575 N-Methyl-D-aspartic Acid, Hydrate - CAS 6384-92-5 - Calbiochem Excitatory amino acid neurotransmitter. Cell permeable: no
Primary Target
Glutamate receptor that regulates Ca2+ channels
Product does not compete with ATP.
Reversible: no
445874 mGluR5 Antagonist, MTEP - CAS 329205-68-7 - Calbiochem The mGluR5 Antagonist, MTEP, also referenced under CAS 329205-68-7, controls the biological activity of mGluR5. This small molecule/inhibitor is primarily used for Neuroscience applications. Cell permeable: yes
Primary Target
mGluR5
Product does not compete with ATP.
Reversible: no
Target IC50: 5 nM in Ca2+-flux assay
Target Ki: 16 nM for mGluR5 (metabotropic glutamate receptor subtype-5)
445865 mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem A pyrazole amide compound that crosses the blood-brain barrier and acts as a potent, selective, reversible, positive allosteric modulator for metabotropic glutamate receptor subtype 5 (mGluR5). Cell permeable: no
EC50 = 10 nM in potentiating the response to glutamate (~300 nM) in CHO-mGluR5 cells for human, 4-fold potentiation; 20 nM for rat, 4.3-fold potentiation
Primary Target
Metabotropic glutamate receptor subtype 5 (mGluR5)
Product does not compete with ATP.
Reversible: yes
05-23-0310 Natriuretic Peptide, C-Type, Human and Porcine - CAS 127869-51-6 - Calbiochem Member of the natriuretic peptide family that shares structural homology with ANP and plays a role in the regulation of body fluid homeostasis, vascular tone, and vascular growth. Cell permeable: no
Primary Target
Adenylate cyclase, particulate guanylate cyclase
Product does not compete with ATP.
Reversible: no
480026 NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC₅₀~ 50 µM in HCT116 cells). Cell permeable: yes
Primary Target
NEMO-binding peptide
Reversible: yes
05-23-1200 Neurotensin - CAS 39379-15-2 - Calbiochem Potent hypothalamic peptide neurotransmitter. Cell permeable: no
Primary Target
Modulator of noradrenergic activity
Product does not compete with ATP.
Reversible: no
481981 Nifedipine - CAS 21829-25-4 - Calbiochem Relatively selective blocker of L-type Ca2+ channels. Cell permeable: no
Primary Target
L-type Ca2+ channels
Product does not compete with ATP.
Reversible: no
454586 NMDAR2C/2D Inhibitor, DQP-1105 - Calbiochem The NMDAR2C/2D Inhibitor, DQP-1105 controls the biological activity of NMDAR2C/2D. This small molecule/inhibitor is primarily used for Neuroscience applications.  
454585 NMDA Receptor NR2BCT(1292-1304)-TAT - Calbiochem A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of NMDAR function  
487960 Nociceptin - CAS 170713-75-4 - Calbiochem Endogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Cell permeable: no
Primary Target
Opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1)
Product does not compete with ATP.
Reversible: no
492031 NS8593 - Calbiochem An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels in a Ca2+-dependent manner.  
552233 QX-314 - CAS 21306-56-9 - Calbiochem A quaternary lidocaine derivative, permanently charged, and lipophobic. Cell permeable: no
Primary Target
A powerful blocker of voltage-sensitive Na+ conductance
Product does not compete with ATP.
Reversible: no
fully active in neurophysiological testing
557324 Riluzole - CAS 1744-22-5 - Calbiochem A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Cell permeable: yes
Primary Target
Inhibits glutamate release and blocks Na+ channels
Product does not compete with ATP.
Reversible: no
676950-M Veratridine - CAS 71-62-5 - Calbiochem A Na+ channel opener. Primary Target
Na+ channel