Somatostatin is a cyclic peptide hormone that inhibits the release of many other hormones and bioactive proteins. First described as a hypothalamic molecule that inhibits release of growth hormone from the anterior pituitary, somatostain has subsequently been found to also inhibit release of ACTH and thyroid stimulating hormone. Somatostatin is found throughout the body, mostly in central and peripheral nervous tissue, and in the gastrointestinal tract and pancreas.

Pancreatic somatostatin inhibits insulin and glucagon release. When secreted by paracrine cells distributed through the length of the gastrointestinal tract it inhibits secretion of various digestive hormones such as gastrin, secretin, and peptide YY. Since the five G-protein coupled somatostatin receptors have tissue-specific distribution patterns and differing affinities for the two forms of the hormone, effects vary widely. Active somatostatin is processed from a pre-prohormone into two disulfide bridged cyclic forms. We offer both somatostatin 14, and somatostatin 28, which has a peptide chain amino-terminal to the somatostatin-14 portion. Somatostatin is available as BioXtra and BioReagent formulations suitable for cell culture applications.

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C4801 Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) ≥95% (HPLC), powder Somatostatin antagonist.
S9129 Somatostatin ≥97% (HPLC), powder Somatostatin regulates the secretion of hormones and bioactive peptides. It acts as an inhibitor in the digestive tract by inhibiting gastrin release. In the pancreatic islets, it inhibits glucagon and insulin release. Somatostatin and its synthetic analogs have been used in the treatment of neuroendocrine tumors.
S1763 Somatostatin powder, BioReagent, suitable for cell culture Somatostatin regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.
Somatostatin (SST) is a peptide. It performs several functions like anti-proliferation, pro-apoptosis and anti-migration. Somatostatin performs physiological activities with the help of various G protein-coupled receptor subtypes (SST receptor (SSTR)-1, SSTR2A, SSTR2B, and SSTR3–5).
S0885 Somatostatin powder, γ-irradiated, BioXtra, suitable for cell culture Somatostatin regulates endocrine function and cell proliferation via interaction with G-protein-coupled somatostatin receptors. It exists in two active forms produced by alternative cleavage of a single preproprotein (14 aa and 28 aa forms). Somatosatin inhibits the release of growth hormone; thyroid-stimulating hormone and a range of gastrointestinal hormones: Cholecystokinin (CCK); Enteroglucagon; Gastrin; Gastric inhibitory polypeptide (GIP); Motilin; Secretin; Vasoactive intestinal peptide (VIP).
S6135 Somatostatin 28 ≥97% (HPLC) Somatostatin action is delivered with help of five different receptor subtypes (sst1 to sst5).
Somatostatin plays an important role in regulating the metabolism of other hormones such as growth hormone, insulin, IGF-1 (insulin-like growth factor 1), glucagon, glucagon-like peptide and gastrin. Somatostatin has both regulatory and inhibitory functions. It retards gastrointestinal motility and gallbladder contraction, suppresses gut exocrine secretion and reduces epithelial proliferation. Somatostatin is associated with intestinal nutrient absorption and blood flow regulation. This peptide hormone is believed to inhibit cell proliferation and promote apoptosis. Somatostatin acts as a neurotransmitter and neuromodulator, and is also associated in maintaining water balance.
S9313 Somatostatin Fragment 2-9 ≥97% (HPLC), solid