Antagonist

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A5330 N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester ≥99% (TLC), powder Competitive substance P receptor antagonist. It is approximately 1000-fold more potent at cloned human NK-1 receptors than at cloned human NK-2 and NK-3 receptors; and approximately 200-fold more potent at human NK-1 receptors than at rat NK-1 receptors. The IC50 for the human NK-1 receptor expressed in CHO cells is approximately 2 nM.
M157 MEN-10,376 ≥95% (HPLC), solid Potent and selective NK-2 tachykinin receptor antagonist.
S3144 [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P ≥95% (HPLC) NK-1 tachykinin receptor antagonist
Somatostatin plays an important role in regulating the metabolism of other hormones such as growth hormone, insulin, IGF-1 (insulin-like growth factor 1), glucagon, glucagon-like peptide and gastrin. Somatostatin has both regulatory and inhibitory functions. It retards gastrointestinal motility and gallbladder contraction, suppresses gut exocrine secretion and reduces epithelial proliferation. Somatostatin is associated with intestinal nutrient absorption and blood flow regulation. This peptide hormone is believed to inhibit cell proliferation and promote apoptosis. Somatostatin acts as a neurotransmitter and neuromodulator, and is also associated in maintaining water balance.
S4152 [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-Substance P acetate salt ≥97% (HPLC) Substance P antagonist
S0145 [D-Pro2, D-Trp7,9]-Substance P acetate salt ≥97% (HPLC) Substance P antagonist
S8031 [pGlu5, D-Trp7,9,10]-Substance P Fragment 5-11 ≥90% (HPLC)