Ligand-Gated Ion Channels

Ligand-gated ion channels are located on the cell membrane. These intrinsic ion channels change shape following the binding of an extracellular ligand to the binding site of the channel. This structural change opens the channel pore, allowing ion transport across the membrane. The pore is typically composed of multiple subunits having an extracellular and a transmembrane domain. Sigma-Aldrich offers a comprehensive selection of bioactive small molecules and antibodies that target ligand-gated ion channel receptors. This class of receptors includes GABA, Glycine, Glutamate, Nicotinic Acetylcholine, and P2X.