Antibodies for Huntington’s Disease Research

Huntington′s Disease (HD) is a progressive genetic neurodegenerative disorder caused by protein malformation and aggregation. Declining muscle coordination and cognitive impairment result, with involuntary muscle movement (chorea) as a major hallmark of this inherited and incurable disorder. Onset is often in middle age. The Huntingtin gene codes for the protein Huntingtin, and a mutation of this gene will lead to the development of HD. When a section of this gene (a trinucleotide) is repeated, the gene is lengthened and as a consequence it produces an altered form of the protein Huntingtin. This protein then codes for the overproduction of the amino acid glutamine, which kills neurons in the human brain. Current research uses antibodies to identify and isolate malformed Huntingtin proteins, to discover their mechanism of neuronal death, and to devise molecular strategies for blocking the toxic effects. Sigma-Aldrich offers monoclonal and polyclonal antibodies for use in Huntington′s Disease research.

Product #

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Form

Gene Symbol (ID)

Species Reactivity

Application

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SAB1402127 Monoclonal Anti-BDNF antibody produced in mouse 1B10, monoclonal
purified immunoglobulin
human ... BDNF(627)
human
ELISA (i), IF, IP, WB
SAB1403694 Monoclonal Anti-CREBBP antibody produced in mouse 2B6, monoclonal
purified immunoglobulin
human ... CREBBP(1387)
human
ELISA (c), ELISA (i), WB
HPA030320 Anti-DLGAP2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... DLGAP2(9228)
human
IHC
HPA003128 Anti-EP300 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... EP300(2033)
human
IF, IHC
G8913 Anti-Glutamate Receptor NMDAR1 (NR1) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GRIN1(2902)
mouse ... Grin1(14810)
rat ... Grin1(24408)
mouse, rat, human
WB
SAB4200293 Anti-HAP1 (C-terminal) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... HAP1(9001)
human
WB
H2539 Anti-HAP40 antibody produced in rabbit polyclonal
affinity isolated antibody
mouse ... F8A1(14070)
mouse
WB
HPA013606 Anti-HIP1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... HIP1(3092)
mouse, human, rat
IF, IHC
H7414 Anti-HIP14 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... ZDHHC17(23390)
mouse ... Zdhhc17(320150)
human, mouse, rat, canine, bovine
WB
SAB2500508 Anti-HIP14/ZDHHC17 antibody produced in goat polyclonal
affinity isolated antibody
human ... ZDHHC17(23390)
human, mouse
ELISA (i), IHC, WB
H0163 Monoclonal Anti-Histone Deacetylase 4 (HDAC4) antibody produced in mouse HDAC4-144, monoclonal
purified immunoglobulin
human ... HDAC4(9759)
mouse ... Hdac4(208727)
rat ... Hdac4(363287)
mouse, human, rat
ICC, IP, WB
H6287 Anti-Histone Deacetylase 1 (HDAC1) antibody, Mouse monoclonal HDAC1-21, monoclonal
purified immunoglobulin
human ... HDAC1(3065)
mouse ... Hdac1(433759)
mouse, human
ARR, ELISA (i), IP, WB
H2663 Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal HDAC2-62, monoclonal
purified immunoglobulin
human ... HDAC2(3066)
mouse ... Hdac2(15182)
rat ... Hdac2(84577)
canine, mouse, rat, chicken, human, bovine
ARR, ELISA (i), IHC, IP, WB
H4538 Monoclonal Anti-Histone Deacetylase 5 (HDAC5) antibody produced in mouse HDAC5-35, monoclonal
purified immunoglobulin
human ... HDAC5(10014)
mouse ... Hdac5(15184)
rat ... Hdac5(84580)
mouse, rat, human
ARR, ELISA (i), ICC, IP, WB
H7540 Anti-Huntingtin (N-terminal) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... HTT(3064)
mouse ... Htt(15194)
rat ... Htt(29424)
mouse, rat, human
WB
H7415 Anti-Huntingtin (N-terminal region) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... HTT(3064)
mouse ... Htt(15194)
rat ... Htt(29424)
human
WB
N3663 Anti-NeuroD1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... NEUROD1(4760)
mouse ... Neurod1(18012)
rat ... Neurod1(29458)
rat, mouse, human
WB
P1874 Monoclonal Anti-Polyglutamines antibody produced in mouse 3B5H10, monoclonal
purified immunoglobulin
human ... HTT(3064)
human
ICC, IP, WB
S6695 Anti-Sin3A, C-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... SIN3A(25942)
mouse ... Sin3a(20466)
rat ... Sin3a(363067)
human
ARR, IP, WB
T1827 Monoclonal Anti-TBP antibody produced in mouse 58C9, monoclonal
purified immunoglobulin
Drosophila melanogaster ... Tbp(37476)
human ... TBP(6908)
Drosophila melanogaster, human, yeast, Sf9 cell line
IP, WB
HPA016807 Anti-ZDHHC17 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... ZDHHC17(23390)
human
IF, IHC
AV47141 Anti-ZDHHC17 (AB1) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... ZDHHC17(23390)
mouse, rabbit, rat, bovine, human, zebrafish, horse, guinea pig
WB
AV47142 Anti-ZDHHC17 (AB2) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... ZDHHC17(23390)
horse, rat, rabbit, guinea pig, mouse, zebrafish, bovine, human
WB