Coagulation, the process of liquid blood forming solid clots, involves a cascade of reactions between coagulation factor proteins and platelet cofactors. Anticoagulants interfere with this complex process, either within the thrombin system or with the platelet activation. This activity makes anticoagulants useful in treating stroke, transient ischaemic attacks, deep vein thrombosis, myocradial infarction, and pulmonary embolisms. Sigma offers therapeutics such as Acenocoumarol (Cat. No. SML0074), an anticoagulant that inhibits Vitamin K epoxide reductase, as well as Argatroban (Cat. No. A0487) and Clopidogrel (Cat. No. SML0004) which directly inhibit thrombin for research purposes. Other anticoagulants available at Sigma include but are not limited to Nafamostat (Cat. No. N0289), Polyanetholsulfonic acid (Cat. No. P2008), and Prasugrel (Cat. No. SML0331).

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SML0074 Acenocoumarol ≥98% (HPLC)
A0487 Argatroban monohydrate ≥98% (HPLC)
SML1737 Beraprost sodium ≥98% (HPLC)
SML1051 Bivalirudin trifluoroacetate salt ≥97% (HPLC)
S5770 Citrate Concentrated Solution BioReagent, suitable for coagulation assays, 4 % (w/v)
C3821 Citrate-dextrose solution (ACD) sterile-filtered
C7165 Citrate-phosphate-dextrose solution aseptically filled
C4431 Citrate-phosphate-dextrose solution with adenine
SML0004 (S)-(+)-Clopidogrel hydrogensulfate ≥98% (HPLC)
SML1042 Eptifibatide acetate ≥98% (HPLC)
2854 Ethylenediaminetetraacetic acid disodium salt solution 2%, solution
SML1240 Fondaparinux sodium ≥95% (HPLC)
H3393 Heparin sodium salt from porcine intestinal mucosa Grade I-A, ≥180 USP units/mg
H6894 [Tyr(SO3H)63]-Hirudin Fragment 54-65 ≥95% (HPLC)
H0393 Hirudin recombinant, expressed in unspecified host, ≥7,000 ATU/mg protein (ATU = antithrombin units)
SML1651 Iloprost ≥98% (HPLC)
SML1439 ML354 ≥98% (HPLC)
N0289 Nafamostat mesylate ≥98% (HPLC)
P2008 Polyanetholesulfonic acid sodium salt powder
P8824 Polyanetholesulfonic acid sodium salt BioUltra
SML0331 Prasugrel ≥98% (HPLC)
T6580 Triflusal ≥98% (HPLC), powder
SML1768 Ximelagatran ≥98% (HPLC)