Peptide Toxins

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A6719 ω-Agatoxin IVA ≥90% (HPLC) Mutations in the CACNA1A (calcium voltage-gated channel subunit alpha1 A) gene is responsible for episodic ataxia 2, familial hemiplegic migraine type 1 (FHM1) and spinocerebellar ataxia type 6 (SCA6).
Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective blocker of mammalian P-type voltage-dependent calcium channels.
A2202 ω-Agatoxin TK ~98% (HPLC), powder Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective P-type and Q-type calcium-channel blocker, without effect on L-type, N-type, or T-type calcium channels. Used to differentiate the types of calcium channel active during various physiological processes
A7475 Anthopleurin-A trifluoroacetate salt >88% (HPLC) Shown to have inotropic effects and not chronotropic effects on mammalian heart preparations.
C9915 ω-Conotoxin GVIA ≥97% (HPLC) Blocks specific voltage-dependent N-type Ca2+ channels in neurons, but not in muscle; does not bind to either the dihydropyridine or verapamil binding sites; peptide first isolated from the marine snail Conus geographus L.
ω-Conotoxin GVIA is a 27 amino acid neurotoxin containing three disulfide bonds. It inhibits central neurotransmitter release and also exhibits antihypertensive, analgesic and neuroprotective activities.
C1182 ω-Conotoxin MVIIA ≥95% (HPLC) Neuronal N-type Ca2+ channel blocker in mammalian and amphibian brain; blocks release of GABA and glutamate at neuronal synapses.
C4188 ω-Conotoxin MVIIC ≥95% (HPLC) Inhibits Ca2+ channels resistant to ω-Conotoxin GVIA; blocks hippocampal excitatory post-synaptic potential (EPSPs) suggesting an interaction with Q-type voltage-sensitive Ca2+ channels (VSCC); originally isolated from marine snail Conus geographus.
K1514 Kurtoxin Kurtoxin is isolated from the venom of the South African scorpion Parabuthus transvaalicus. It associates with voltage-gated sodium channels and delays their inactivation.
T-type Ca2+ channel blocker; Scorpion toxin