Mitochondrial Inhibitors

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164603 3-Nitropropionic acid - CAS 504-88-1 - Calbiochem A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme.
203671 Bongkrekic Acid, Triammonium Salt - CAS 1177154-51-6 - Calbiochem Bongkrekic Acid, Triammonium Salt, CAS 1177154-51-6, acts as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore)., Acts as a ligand of the adenine nucleotide translocator.
215911 Carbonyl Cyanide m-Chlorophenylhydrazone - CAS 555-60-2 - Calbiochem Carbonyl Cyanide m-Chlorophenylhydrazone, CAS 555-60-2, is a protonophore uncoupling agent for oxidative phosphorylation. Shown to be about 100-fold more effective than 2, 4-DNP., Protonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol.
216201 Carboxyatractyloside, Potassium Salt, Xanthium sibiricum - CAS 35988-42-2 - Calbiochem
220005 CGP-37157 - CAS 75450-34-9 - Calbiochem A cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC₅₀ = 360 nM).
328501 ERO1 Inhibitor II, EN460 - Calbiochem
329600 Erastin - CAS 571203-78-6 - Calbiochem Erastin, CAS 571203-78-6, is a cell-permeable compound that binds to VDAC to alter its gating. Induces non-apoptotic cell death in tumor cells harboring activating mutations in RAS-RAF-MEK signaling., A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.
376816 Hexokinase II VDAC Binding Domain Peptide, Cell-Permeable - Calbiochem A cell-permeable peptide analog of Hexokinase II VDAC binding domain peptide.
376817-M Hexokinase II Inhibitor II, 3-BP - CAS 1113-59-3 - Calbiochem The Hexokinase II Inhibitor II, 3-BP, also referenced under CAS 1113-59-3, controls the biological activity of Hexokinase II. This small molecule/inhibitor is primarily used for Cell Structure applications.
407721 m-Iodobenzylguanidine, Hemisulfate - CAS 80663-95-2 - Calbiochem A cell-permeable norepinephrine analog that displays antiproliferative and proapoptotic properties.
475856 Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.
495455 Oligomycin - CAS 1404-19-9 - Calbiochem Oligomycin, CAS 1404-19-9, is a macrolide antibiotic that inhibits membrane-bound mitochondrial ATP synthase and prevents phosphoryl group transfer. It is a mixture of A, B, and C isomers., A mixture of A, B, and C isomers.
5.04817 Mitochondrial Pyruvate Carrier Inhibitor, UK5099 - CAS 56396-35-1 - Calbiochem
5.05759 MitoBloCK-6 - Calbiochem
5.30655 Mitochondrial GPDH Inhibitor, iGP-1 - Calbiochem A cell-permeable, potent, selective, and dose-dependent inhibitor of mitochondrial, but not cytosolic, sn-glycerol-3-phosphate dehydrogenase (IC₅₀ against mGPDH = 6.3 µM).
5.38098 GDH1 Inhibitor, R162 - Calbiochem A cell-potent, bioavailable & non-toxic GDH1 inhibitor that decreases cancer cell proliferation and tumor growth. Attenuates GPx activity, elevates ROS levels and impairs redox homeostasis.
557368 Rotenone - CAS 83-79-4 - Calbiochem A mitochondrial toxin and a potent, reversible, and competitive inhibitor of complex I (NADH-CoQ reductase) of the respiratory chain.
557440 Ru360 - Calbiochem Ru360, is a cell-permeable oxygen-bridged dinuclear ruthenium amine complex. Binds to mitochondria with high affinity (Kd = 340 pM) and blocks Ca2+ uptake into mitochondria in vitro (IC₅₀ = 184 pM).
676377 Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem A cyclododecadepsi-peptide ionophore antibiotic.
A8674 Antimycin A from Streptomyces sp.
BM0017 BMS-199264 hydrochloride ≥98% (HPLC)
SML1122 BTB06584 ≥98% (HPLC)
C2759 Carbonyl cyanide 3-chlorophenylhydrazone ≥97% (TLC), powder
C2920 Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone ≥98% (TLC), powder
C2020 α-Cyano-4-hydroxycinnamic acid ≥98% (TLC), powder
I9890 m-Iodobenzylguanidine hemisulfate salt ≥98% (HPLC and TLC)
L4900 Lonidamine mitochondrial hexokinase inhibitor
M2324 ML-3H2
O4876 Oligomycin from Streptomyces diastatochromogenes ≥90% total oligomycins basis (HPLC)
P8861 Pyrrolnitrin from Pseudomonas cepacia ≥98% (HPLC), solid
R8875 Rotenone ≥95%
SML1280 TT01001 ≥98% (HPLC)