Phosphatase Inhibitors

Researchers often encounter the need to protect proteins (including phosphoproteins) from degradation during and after cell lysis and tissue protein extraction. This need often includes the preservation of the phosphorylation state (activation state) of the proteins, especially when it is that particular characteristic that is being investigated.

Phosphoprotein activation states can act as on/off switches for key cell functions like signal transduction, cell division, cell death, and calcium signaling. In order to study these types of factors, endogenous enzymes called phosphatases must be inactivated to prevent their uncontrolled activity after cell lysis. Threats to the phosphorylation state are posed by serine/threonine phosphatases as well as by protein tyrosine phosphatases (PTPs).

Sigma-Aldrich formulations of phosphatase and phosphorylase inhibitors provide protection from dephosphorylation by blocking or inactivating the endogenous enzymes that are released during cells lysis. These enzymes would otherwise affect the proteins of interest and their activation states.

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SML0294 ABL127 ≥98% (HPLC)
SML1022 AS1949490 ≥98% (HPLC)
SML1079 BMOV ≥95% (elemental analysis)
SML0884 bpV(HOpic) ≥90% V basis
SML0889 bpV(phen) ≥95% V basis
SML0885 bpV(pic) ≥95% V basis
SML1536 (-)-p-Bromolevamisole oxalate Ready Made Solution 0.8 mg/mL in DMSO
C5552 Calyculin A from Discodermia calyx ≥90% (HPLC), solid
C7632 Cantharidin
SML1537 Cantharidin Ready Made Solution 0.1 mg/mL in DMSO
SML1545 Claramine trifluoroacetate salt ≥98% (HPLC)
PZ0189 CP-316819 ≥98% (HPLC)
PZ0104 CP-91149 ≥98% (HPLC)
PZ0240 (S)-Crizotinib ≥98% (HPLC)
SML1739 CX08005 ≥98% (HPLC)
E1904 Ethyl-3,4-dephostatin >99% (HPLC), solid
F4425 Fostriecin sodium salt from Streptomyces pulveraceus ≥98% (HPLC)
SML1147 IQ-1 ≥95% (HPLC)
M9440 Methyl-3,4-dephostatin >98% (HPLC), powder
SML0901 ML095 hydrochloride ≥98% (HPLC)
N8784 Norcantharidin solid
N1786 NSC 95397 ≥97% (HPLC)
O8010 Okadaic acid ammonium salt from Prorocentrum concavum ≥90% (HPLC), solid
O9381 Okadaic acid from Prorocentrum concavum 92-100% (HPLC)
O7885 Okadaic acid potassium salt from Prorocentrum concavum ≥90% (HPLC), powder
O7760 Okadaic acid sodium salt from Prorocentrum concavum ≥90% (HPLC), film
P3075 Phenylarsine oxide ≥97%, powder
P0044 Phosphatase Inhibitor Cocktail 3 DMSO solution
P2850 Phosphatase Inhibitor Cocktail 1 DMSO solution
P5726 Phosphatase Inhibitor Cocktail 2 aqueous solution (dark coloration may develop upon storage, which does not affect the activity)
SML1437 Pimecrolimus ≥97% (HPLC)
P2118 Protein Phosphatase 2A Inhibitor Protein, 1‑α human recombinant, expressed in E. coli, buffered aqueous glycerol solution
P6993 Protein Phosphatase 2A1 bovine ≥1500 units/mg protein
P1868 Protein Phosphatase 2A2 from bovine kidney buffered aqueous glycerol solution
SML0684 SF1670 ≥98% (HPLC)
S6508 Sodium orthovanadate ≥90% (titration)
SML1069 TH287 hydrochloride ≥98% (HPLC)
SML1096 TH588 hydrochloride ≥98% (HPLC)