Protein Kinase Activators

Protein kinases are enzymes that add a phosphate group to a protein or other organic molecule (phosphorylation). Phosphorylation usually alters the functional characteristics of the target protein and can act as an on/off switch for protein functions. Most protein kinases act on the amino acids serine and threonine, while tyrosine kinases act on tyrosine, and some protein kinases act on all three. A protein kinase activator enhances phosphorylation.

Protein kinases regulate critical cellular functions like cell cycle, metabolism, differentiation, proliferation, and apoptosis. Kinase dysfunction is also connected to a variety of human diseases including cancer, inflammatory conditions, autoimmune disorders, and cardiac diseases. As a result, protein kinase inhibitors are important research tools to study cell functions and human diseases.

Protein phosphorylation is one of the most important molecular mechanisms by which extracellular signals produce their biological responses in cells. Sigma-Aldrich offers a variety of protein kinase activators for the study of protein and cell functions.

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A9789 Anisomycin from Streptomyces griseolus ≥98% (HPLC), solid
B7431 Bryostatin 1 ≥99%, solid
D7821 dPPA ≥98% (HPLC)
L0521 Lipoxin A4 ethanol solution
O1008 Oleic acid ≥99% (GC)
PZ0320 PF-04937319 ≥98% (HPLC)
PZ0306 PF-6808472 ≥98% (HPLC)
P2803 N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide
P1269 Phorbol 12,13-dibutyrate ≥98% (TLC), powder
P8014 4α-Phorbol 12,13-didecanoate solid
P148 4α-Phorbol 12-myristate 13-acetate solid, ≥95% (TLC)
P8139 Phorbol 12-myristate 13-acetate ≥99% (TLC), film or powder
P0077 Prostratin ≥98% (HPLC)