Protein Kinase Inhibitors

A protein kinase is an enzyme that modifies proteins by transferring a phosphate group from ATP. This phosphorylation creates a phosphoprotein with altered protein activity, often acting as an on/off switch for protein functions. Protein kinases regulate cell functions like signal transduction, cell cycle, metabolism, differentiation, proliferation, and apoptosis. Protein kinases act on the amino acids serine, threonine, and tyrosine. A protein kinase inhibitor is a compound that blocks the action of one or more protein kinases.

Protein kinase dysfunction is connected to a wide variety of human diseases and conditions including cancer, inflammatory conditions, autoimmune disorders, and cardiac diseases. Protein kinase inhibitors are important research tools to study cell functions and human diseases. In some cases protein kinase inhibitors block cell proliferation, as in certain disease conditions. Sigma-Aldrich has a broad range of protein kinase inhibitors for use in the research of protein and cell functions.

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A2846 A-134974 dihydrochloride hydrate ≥98% (HPLC), solid
A4970 N-Acetyl-O-phosphono-Tyr-Glu Dipentylamide
SML1110 Adaphostin ≥98% (HPLC)
A6730 Akt1/2 kinase inhibitor ≥98% (HPLC)
A7410 Amiloride hydrochloride hydrate ≥98% (HPLC), powder
A3230 AR-A014418 ≥98% (HPLC), solid
A4308 Autocamtide 2-related inhibitory peptide ≥97% (HPLC), lyophilized powder
SML1427 AZ3146 ≥98% (HPLC)
B9685 BAY 61-3606 hydrochloride hydrate ≥98% (HPLC), powder
B3936 BAY R3401 ≥98% (HPLC), solid
B3686 BAY U6751 hydrate solid, ≥98% (HPLC)
B1686 BIO ≥98% (HPLC)
B3056 Bisindolylmaleimide II ≥97% (Mixture of 2 isomers)
B3306 Bisindolylmaleimide IV ≥98% (TLC), solid
B3681 Bisindolylmaleimide VII 96% (TLC), solid
B3931 Bisindolylmaleimide X hydrochloride ≥90%, solid
B4056 Bisindolylmaleimide XI hydrochloride ≥98% (TLC), solid
B7563 BRD7389 ≥98% (HPLC)
B178 Butein solid
C6303 Calphostin C from Cladosporium cladosporioides ≥90% (HPLC), powder
C9867 CGK733 ≥98% (HPLC), solid
C2932 Chelerythrine chloride ≥95% (TLC), powder
C3742 Chk2 Inhibitor II hydrate ≥98% (HPLC)
C0742 CKI-7 dihydrochloride ≥98% (HPLC), solid
SML1212 CPI203 ≥98% (HPLC)
SML0804 (S)-CPP sodium salt ≥96% (HPLC)
C8863 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine ≥98% (HPLC)
D0817 (−)-Deguelin >98% (HPLC), powder
D3768 Dequalinium chloride hydrate ≥95% (titration)
D1916 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside
D5564 7,8-Dihydroxycoumarin ≥97%, powder
P5499 Dorsomorphin ≥98% (HPLC)
E7881 Emodin from Frangula bark, ≥90% (HPLC)
341207 ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells.
SML1321 ETP-46464 ≥98% (HPLC)
G3381 Geldanamycin from Streptomyces hygroscopicus ≥98% (HPLC), powder
SML1277 Geldanamycin-FITC ≥98% (HPLC), from Streptomyces hygroscopicus
SML1278 Geldanamycin Ready Made Solution 1 mg/mL, from Streptomyces hygroscopicus
G6649 Genistein synthetic, ≥98% (HPLC), powder
G6776 Genistein from Glycine max (soybean), ~98% (HPLC)
G0897 Genistin from Glycine max (soybean), ≥95% (HPLC)
G2911 GF 109203X synthetic, ≥90% (HPLC)
B6292 GF 109203X hydrochloride ≥95%
G1918 Gö 6983 ≥97%
SML0660 GSK2578215A ≥98% (HPLC)
G0668 GW2974 ≥98% (HPLC), solid
G6416 GW5074 powder
I6891 H-7
I7016 H-7 dihydrochloride ≥98% (HPLC)
M9656 H-8 dihydrochloride >98% (HPLC)
B1427 H-89 dihydrochloride hydrate ≥98% (HPLC), powder
H6649 Herbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder
H5257 Hispidin solid, ≥98% (HPLC)
I0658 IC 261 ≥98% (HPLC)
124031 InhibitorSelect Akt/PI 3-K/mTOR Signaling Pathway Inhibitor Panel InhibitorSelect™ Akt/PI 3-K/mTOR Signaling Pathway Inhibitor Panel contains 2 highly potent and selective kinase inhibitors and a negative control for studying Akt/PI 3-K/mTOR signaling pathway.
440204 InSolution LY 294002 - CAS 154447-36-6 - Calbiochem InSolution™ LY 294002, CAS 154447-36-6, is a 10 mM solution of LY 294002 (Cat. No. 440202) in DMSO. A cell-permeable, potent, reversible and specific inhibitor of PI 3-kinase (IC50 = 1.4 µM).
528101 InSolution PI-103
553212-M InSolution Rapamycin in EtOH The InSolution™ Rapamycin, also referenced under CAS 53123-88-9, controls the biological activity of mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
681676 InSolution Wortmannin - Calbiochem Wortmannin is a fungal metabolite that acts as a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase).
05288 K-252a from Nocardiopsis sp.
K1639 K-252a from Nonomuraea longicatena, ≥98% (HPLC)
K2015 K-252a Ready Made Solution, from Nonomuraea longicatena, >98%
I2142 KN-62 ≥95%, powder
K1385 KN-93 ≥98% (HPLC)
K3761 KT 5720 ≥98% (HPLC), powder
K1388 KT 5823 ≥85% (HPLC), lyophilized powder
SML1788 LJI308 ≥98% (HPLC)
19-142 LY 294002
440202 LY 294002 - CAS 154447-36-6 - Calbiochem LY294002, CAS 154447-36-6, is a cell-permeable, potent, reversible, and specific inhibitor of PI 3-kinase ((IC₅₀ = 1.4 µM). Acts on the ATP-binding site.
440206 LY 294002, 4ʹ-NH₂ - CAS 942289-87-4 - Calbiochem A cell-permeable LY 294002 4'-amino derivative with enhanced potency against p110α/β/δ/γ.
440203 LY 303511 - CAS 154447-38-8 - Calbiochem A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002.
L6293 LY-364947 ≥98% (HPLC)
M7795 rac-2-Methoxy-3-hexadecanamido-1-propylphosphocholine ≥90%
I2764 ML-7 powder
C1172 ML-9 ≥99% (TLC), powder
SML1477 MPI-0479605 hydrochloride ≥98% (HPLC)
M8059 [Ala107]-Myelin Basic Protein Fragment 104-118
M8309 [Ala113]-Myelin Basic Protein Fragment 104-118 synthetic, lyophilized powder
M6760 Myricetin ≥96.0%, crystalline
476275 Myricetin - CAS 529-44-2 - Calbiochem A cell-permeable flavanoid that displays anti-inflammatory, anti-diabetic and anti-cancer properties.
N161 NPC-15437 dihydrochloride hydrate ≥97% (NMR), powder
SML0185 NQDI-1 ≥98% (HPLC)
N9289 NVP-231 ≥98% (HPLC)
P4509 Palmitoyl-DL-carnitine chloride powder
P215 PD 98,059 solid
PZ0116 PD-166285 hydrate ≥98% (HPLC)
528100 PI-103 - CAS 371935-74-9 - Calbiochem A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR.
526559 PI3Kδ Inhibitor, SW30 - Calbiochem The PI3Kδ Inhibitor, SW30 controls the biological activity of PI3Kδ. This small molecule/inhibitor is primarily used for Membrane applications.
P0453 Piceatannol powder
528106 PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem The PI 3-Kγ Inhibitor, also referenced under CAS 648450-29-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
528118 PI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2 - Calbiochem PI 3-Kδ Inhibitor X, IC87114, CAS 371242-69-2, is a cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110, p110, and p110, respectively).
528108 PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem The PI 3-Kγ Inhibitor II, also referenced under CAS 648449-76-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
528111 PI 3-Kα Inhibitor IV - CAS 1188890-32-5 - Calbiochem The PI 3-Kα Inhibitor IV, also referenced under CAS 1188890-32-5, controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
528117 PI 3-K inhibitor IX, PIK-90 - CAS 677338-12-4 - Calbiochem The PI 3-K inhibitor IX, PIK-90, also referenced under CAS 677338-12-4, controls the biological activity of PI 3-K. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
528122 PI 3,4-K inhibitor, PIK-93 - CAS 593960-11-3 - Calbiochem The PI 3,4-K inhibitor, PIK-93, also referenced under CAS 593960-11-3, controls the biological activity of PI 3,4-K. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
528114 PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem The PI 3-Kγ Inhibitor VII, also referenced under CAS 6318-41-8, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
528116 PI 3-Kα Inhibitor VIII - CAS 372196-77-5 - Calbiochem The PI 3-Kα Inhibitor VIII controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
528113 PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem The PI 3-Kβ Inhibitor VI, TGX-221, also referenced under CAS 663619-89-4, controls the biological activity of PI 3-Kβ. This small molecule/inhibitor is primarily used for Cell Signaling applications.
528119 PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem The PI 3-K Inhibitor XI, HWT, also referenced under CAS 58053-83-1, controls the biological activity of PI 3-K. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
526560 PI 3-Kδ/γ Inhibitor XV, SW-14 - Calbiochem The PI 3-Kδ/γ Inhibitor XV, SW-14 controls the biological activity of PI 3-Kδ/γ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
5.09226 PI 3-K Inhibitor XXI, GDC-0941 - CAS 957054-30-7 - Calbiochem
524611-M PIKfyve Inhibitor - CAS 371942-69-7 - Calbiochem The PIKfyve Inhibitor, also referenced under CAS 371942-69-7, controls the biological activity of PIKfyve. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
528121 PI 3-K/PDK-1 Inhibitor, NVP-BAG956 - CAS 853910-02-8 - Calbiochem The PI 3-K/PDK-1 Inhibitor, NVP-BAG956, also referenced under CAS 853910-02-8, controls the biological activity of PI 3-K/PDK-1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
P1004 Polymyxin B sulfate salt
5295 Polyvinylpyrrolidone - CAS 9003-39-8 - Calbiochem Polymer used as a pharmaceutical aid, complexing agent, and a solubilizer.
P6062 Protein Kinase A Inhibitor Fragment 6-22 amide ≥97% (HPLC)
P3115 Protein Kinase C Inhibitor, Myristoylated ≥7.5 mg/mL (peptide and counter ion), ≥95% (Minimum peptide content 70%, HPLC), aqueous solution (neutral pH)
P1614 Protein kinase Cζ pseudosubstrate, myristoyl trifluoroacetate salt ≥90% (HPLC)
P0393 Protein Kinase Inhibitor from porcine heart 1-3 inhibitor U/μg protein, lyophilized powder
P0300 Protein Kinase Inhibitor from rabbit ≥85% (HPLC)
P6624 PS-1145 dihydrochloride ≥98% (HPLC), solid
529584 PTK/PI 3-K/mTOR Inhibitor, PP121 - CAS 1092788-83-4 - Calbiochem The PTK/PI 3-K/mTOR Inhibitor, PP121, also referenced under CAS 1092788-83-4, controls the biological activity of PTK/PI 3-K/mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
551600-M Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem A cell-permeable and reversible inhibitor of PIM1 kinase (IC₅₀ = 43 nM), PI 3-K (IC₅₀ = 3.8 µM) and phospholipase A2 (IC₅₀ = 2 µM).
R2146 Radicicol from Diheterospora chlamydosporia solid Green Alternative
R136 Ro 31-8220 methanesulfonate salt solid
R137 Ro 31-0432 solid
R5648 Rottlerin
S7067 SB 202190 ≥98% (HPLC)
S8307 SB 203580 solid, ≥98% (HPLC)
S3442 SB 216763 >98% (HPLC)
S9070 SB 220025 trihydrochloride ≥98% (HPLC), solid
S0569 SB 239063 >98% (HPLC)
S3567 SB 415286 ≥98% (HPLC)
S4696 SB-505124 hydrochloride hydrate ≥98% (HPLC)
SML0014 Scutellarin hydrate ≥98% (HPLC)
565840 SHIP2 Inhibitor, AS1938909 - Calbiochem The SHIP2 Inhibitor, AS1938909 controls the biological activity of SHIP2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
5.08318 SHIP2 Inhibitor II, CPDA - Calbiochem
S0193 SKF-86002 ≥98% (HPLC), solid
S5696 SKI II ≥98% (HPLC), solid
S5567 SP600125 ≥98% (HPLC)
S4400 Staurosporine from Streptomyces sp. ≥98% (HPLC), film
SML1728 STK16-IN-1 ≥98% (HPLC)
S8567 SU 4312 ≥98% (HPLC)
S8442 SU 5416 ≥98% (HPLC)
S9692 SU 6656 ≥98% (HPLC)
T6951 TBBz ≥98% (HPLC), powder
T7040 Tyrphostin 1 ≥98%
T7165 Tyrphostin 23 ≥98%
T7665 Tyrphostin 51 ≥98%
T182 Tyrphostin A9 solid
T7697 I-OMe-Tyrphostin AG 538 solid
T5068 Tyrphostin AG 658 ≥98%, solid
T5443 Tyrphostin AG 825 ≥92.5%
T5568 Tyrphostin AG 835 ≥92%
T2067 Tyrphostin AG 879 99% (HPLC)
T5818 Tyrphostin AG 974 ≥98%, solid
T5943 Tyrphostin AG 1007 ≥98%, solid
T6193 Tyrphostin AG 1112 ≥98%, solid
T4182 Tyrphostin AG 1478 ≥98%
T3434 Tyrphostin AG 490 solid
T6568 Tyrphostin RG 13022 ≥98%
T6693 Tyrphostin RG 14620 ≥98%
U120 U0126 monoethanolate ≥98% (HPLC), powder
SRP4915 Vaspin human recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)
SML1415 VE-821 ≥98% (HPLC)
681675 Wortmannin - CAS 19545-26-7 - Calbiochem Wortmannin, CAS 19545-26-7, is a cell-permeable, potent, selective, and irreversible inhibitor of PI3-Kinase (IC₅₀ = 5 nM). Does not affect any upstream signaling events.
Y0503 Y-27632 dihydrochloride ≥98% (HPLC)
Z4626 ZM 39923 hydrochloride >98% (HPLC)