Agonists

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P4532 (−)-N6-(2-Phenylisopropyl)adenosine solid A1 adenosine receptor agonist. Affinity for adenosine receptor is approx. 100× that of the (+)-isomer.
P101 2-Phenylaminoadenosine >97%, solid Selective A2 adenosine receptor agonist; potent coronary vasodilator; weak inhibitor of adenosine uptake by rat cerebral cortical synaptosomes.
C5134 2-Chloroadenosine 2-Chloroadenosine is an analog of adenosine. It is an adenosine A1 receptor agonist. It might possess anti-oxidant property.
E2387 5′-(N-Ethylcarboxamido)adenosine powder Potent adenosine receptor agonist with nearly equal affinity at A1 and A2 receptors.
B3756 8-Bromoadenosine 5′-triphosphate sodium salt ≥90% (HPLC) P2X purinoceptor agonist similar in reactivity to ATP.
A236 AB-MECA solid High affinity A3 adenosine receptor agonist.
A8016 Adenosine 5′-[β-thio]diphosphate trilithium salt ≥80% (HPLC) P2Y receptor agonist.
A5285 Adenosine 5′-diphosphate monopotassium salt dihydrate bacterial, ≥95%, powder P2Y receptor agonist.
A7699 Adenosine 5′-triphosphate disodium salt hydrate BioXtra, ≥99% (HPLC), from microbial P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems
A111 Adenosine amine congener hydrate solid, ≥98% (HPLC) Potent aqueous-soluble A1 adenosine receptor agonist.
A9251 Adenosine ≥99% Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).
C141 CGS-21680 hydrochloride hydrate solid Adenosine receptor agonist, which possesses selectivity for A2 verses A1 receptors.
C277 Chloro-IB-MECA solid, ≥98% (HPLC) 2-chloro-N(6)-(3-iodobenzyl)adenosine-5′-N-methylcarboxamide (Cl-IB-MECA) is a adenosine receptor. It protects against myocardial ischemia/reperfusion injury in mice.
SML1498 Cinepazide maleate ≥98% (HPLC) Cinepazide maleate is a vasodilator used clinically in China used in China for the treatment of cardiovascular and cerebrovascular diseases, and peripheral vascular diseases. Cinepazide maleate is thought to act as a potentiator of adenosine A2 receptors and has also been characterized as a calcium channel blocker. It was withdrawn for agranulocytosis in several countries.
C1506 Cytidine 5′-triphosphate disodium salt ≥95% Cytidine 5′-triphosphate (CTP) prevents the action of aspartate carbamoyltransferase. This enzyme participates in pyrimidine biosynthesis. Like adenosine triphosphate (ATP), CTP serves as a molecule of high energy. It acts as a coenzyme in glycerophospholipid biosynthesis and protein glycosylation.
P2X4 purinergic receptor agonist.
I146 IB-MECA solid, ≥98% (HPLC) Selective A3 adenosine receptor agonist.
K3769 KW-3902 ≥98% (HPLC) KW-3902 is an A1 adenosine receptor antagonist and is over 800 fold more selective for an A1 receptor versus the A2A receptor.
SML1802 MS0015203 ≥98% (HPLC) MS0015203 is a potent and selective agonist of the neuropeptide receptor GPR171. MS0015203 increases food intake and body weight in mice.
C9901 N6-Cyclohexyladenosine Selective A1 adenosine receptor agonist.
C8031 N6-Cyclopentyladenosine solid Selective A1 adenosine receptor agonist.
S198   N6-p-Sulfophenyladenosine sodium salt solid A1 adenosine receptor agonist.
U4125 Uridine 5′-(trihydrogen diphosphate) sodium salt from Saccharomyces cerevisiae 95-100% P2Y receptor agonist.
U6875 Uridine 5′-triphosphate tris salt Type VI, ≥90% P2Y receptor agonist.
Uridine 5′-triphosphate (UTP) is synthesized from uridine 5′-diphosphate (UDP) in the presence of the enzyme nucleoside diphosphate kinase (NDPK). Plant cells have high uridine as UTP. UTP on amination results in the generation of CTP and is catalysed by enzyme CTP synthetase. UTP acts on the purinergic (P2Y2) receptor and mediates smooth muscle cells (SMCs) mitogenic activation. It also modulates osteopontin expression in SMCs. UTP is a sputum inducer and a promising candidate for assessing the inflammation in respiratory airway.
U6750 Uridine 5′-triphosphate trisodium salt hydrate Type IV, ≥93.0% (HPLC) P2Y receptor agonist.
Uridine-5′-Triphosphate (UTP) is a cytosolic nucleotide component of nucleic acids. It serves as a signaling molecule in the extracellular space. Uridine-5′-Triphosphate (UTP) is involved in various pathophysiological responses in the nervous system. UTP also plays a major role in the regeneration process.
U6625 Uridine 5′-triphosphate trisodium salt hydrate from yeast, Type III, ≥96% P2Y receptor agonist.
M6517 α,β-Methyleneadenosine 5′-triphosphate lithium salt ≥93% (HPLC), solid P2 purinoceptor agonist that is more potent than ATP at the P2X subtype.
M7510 β,γ-Methyleneadenosine 5′-triphosphate disodium salt ≥95%, solid Selective P2X purinoceptor agonist that is more potent than ATP, but less potent than α, β-methylene-L-adenosine 5′-triphosphate.