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SML0926 ML314 maleate ≥98% (HPLC) ML314 is a biased agonist of the Neruotensin 1 (NTR1) receptor. ML314 induces recruitment of β-arrestin to NTR1 with an EC50 of 2 μM, but does not induce G-protein mediated Ca2+ mobilization.
SCP0200 Neuromedin N ≥97% (HPLC) Neuromedin N is a hexapeptide that is related to neurotensin. Its precursor, proneuromedin N, is expressed in the adrenals, brain, gut and also in several cancers. In myoelectric activity, it has been reported to act in a similar manner as neurotensin, at a lesser degree of potency. Neuromedin N has been shown to increase the chemotaxis capacity of mouse lymphocytes and to modulate function of the hypothalamo-pituitary-adrenocortical axis in rats. Neuromedin N has been proposed to exert its actions via increase in intracellular Ca2+ concentration, although this is uncertain.
N6383 Neurotensin ≥90% (HPLC) Neurotensin (NT) acts as an inducer for analgesia, hypothermia and hyperglycemia, and is an inhibitor of gastric motility. Plasma NT levels are high in children with Prader–Willi syndrome (PWS). NT secreted from small cell lung cancer cells might have a regulatory action in this disease. It has been implicated in regulation of gastric system and inflammatory processes in the lung. In addition, NT also regulates immune response by stimulating cytokine release and chemotaxis on interaction with leukocytes, peritoneal mast cells and dendritic cells. NT present in gastrointestinal (GI) tract plays a vital role in various processes such as stimulation of pancreatic and biliary secretion and enhances growth of various normal tissues. It is involved downstream of Wnt/β-catenin signaling pathway and stimulates the growth of neuroendocrine tumor cells.
N5266 Neurotensin Fragment 8-13 acetate salt ≥97% (HPLC) Neurotensin Fragment 8-13 acetate salt is the smallest active fragment of neurotensin.
PZ0175 PD 149163 tetrahydrochloride hydrate ≥95% (HPLC) PD 149163 is a Neurotensin NTR1 receptor agonist; a Neurotensin (8-13) analog. PD149163 is a selective, brain penetrating NT1 receptor agonist with pro-cognitive, antipsychotic and anxiolytic effects.
SML0278 SR 48692 ≥98% (HPLC) SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist that antagonizes neurotensin-induced calcium mobilization with a pA2 of 8.13 in HT-29 human colon carcinoma cell line, and blocks the ability of neurotensin to increase GABA levels in the prefrontal cortex.