Microtubule Inhibitors

Microtubules are polar, polymeric, cylindrical structures formed in the cytoskeleton from tubulin dimers. They provide structural support for the cell, and play a crucial role in intracellular transport of organelles, mitosis and other cellular processes. Microtubule inhibitors (MTIs, tubulin-inhibiting agents) can bind to tubulin and inhibit microtubule formation, interfere with self-assembly, polymerization or disassembly of microtubules, affect stability, prevent polymerization or inhibit depolymerization. Because their action is metaphase specific and crucial for spindle assembly and function, microtubule inhibitors are prime targets as anti-tumor or anti-malarial agents. Interference of MTIs with the cell cycle can lead to cell death (apoptosis), and microtubule inhibitors can have anti-angiogenic, anti-proliferative, cytostatic or antitumor activity. Sigma offers several microtubule inhibitors, including catharanthine, demecolcine, vinblastine, and vincristine.

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SML0131 ABT-751 hydrochloride ≥98% (HPLC)
A2836 Ansamitocin P-3 from Actinosynnema pretiosum ≥90% (HPLC)
SML0259 Catharanthine ≥95% (HPLC)
C5492 CIL-102 ≥95% (HPLC), solid
C9754 Colchicine ≥95% (HPLC), powder
D7385 Demecolcine ≥98% (HPLC)
D1925 Demecolcine solution 10 μg/mL in HBSS, ACF Qualified, BioXtra
H4663 HMBA ≥98% (HPLC), solid
H9415 5HPP-33 ≥98% (HPLC), solid
SML1903 IMB5046 ≥98% (HPLC)
SML0744 LDN-27219 ≥98% (HPLC)
SML1028 MPT0B014 ≥98% (HPLC)
M3316 Myoseverin B ≥97% (HPLC)
M1404 Nocodazole ≥99% (TLC), powder
SML1310 NSC756093 ≥98% (HPLC)
SML1549 Ombrabulin hydrochloride ≥98% (HPLC)
P4405 Podophyllotoxin
SML1112 Remodelin hydrobromide ≥98% (HPLC)
S7198 Sivelestat sodium salt hydrate ≥98% (HPLC), solid
SML1493 Suprafenacine ≥98% (HPLC)
SML0954 Thiocolchicine ≥97% (HPLC)
T7580 TN-16 ≥98% (HPLC)
V1377 Vinblastine sulfate salt ≥97% (HPLC)
V8879 Vincristine sulfate salt 95.0-105.0% (HPLC), powder or crystals
V2264 Vinorelbine ditartrate salt hydrate ≥98% (HPLC), powder