Acetylcholinesterase

Acetylcholinesterase in Neuroscience

Acetylcholinesterase is the major in vivo degradative enzyme for acetylcholine. It converts acetylcholine and water to choline and acetic acid. Cholinesterases hydrolyze choline esters faster than other substrates and are inhibited by the natural carbamate alkaloid, eserine or physostigmine. These enzymes are serine esterases and are irreversibly inhibited by organophosphates such as diisopropylfluorophosphate (DFP).

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SML1569 Acotiamide dihydrochloride ≥98% (HPLC) Acotiamide is a potent, selective and reversible inhibitor of human and canine stomach-derived acetylcholinesterase (AChE). Acotiamide showed no affinity for dopamine D2 or serotonin 5-HT4 receptors but does have activity as a muscarinic antagonist. It acts as a prokinetic drug through acetylcholinesterase inhibition and muscarinic receptor antagonism, and has been used for the treatment of functional dyspepsia (FD) involving gastric motility dysfunction.
A3773 9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate ≥99%  
A9013 1,5-Bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide Selective acetylcholinesterase inhibitor.
W0641 W-84 dibromide ≥98% (HPLC), solid Potent allosteric modulator of M2 muscarinic acetylcholine receptors.
D0879 Diisopropylfluorophosphate Potent inhibitor of serine proteases such as trypsin and chymotrypsin, and of acetylcholinesterase; also inhibits cathepsin G, cholinesterase, coagulation factor Xa, leucocyte elastase, pancreatic elastase, tissue kallikrein, plasmin, subtilisin, and thrombin. Inhibition of acetylcholinesterase makes this compound especially toxic. Inhibits apoptosis induced by ricin and bacterial toxins.
G1660 Galanthamine hydrobromide from Lycoris sp. ≥94% (HPLC) Cholinesterase inhibitor; reverses scopolamine-induced amnesia; antimyasthenic.
H5777 (±)-Huperzine A synthetic, ≥98% (TLC) Huperzine A is an effective acetylcholinesterase inhibitor and can cross the blood-brain barrier. Huperzine A is known to prevent cognitive defects, glutamate-induced nerve cell death.It is recognized for its use in the treatment of Alzheimer′s disease and organophosphate poisoning.
SML0033 Itopride hydrochloride ≥98% (HPLC) Itopride hydrochloride enhances the gastrointestinal motility by blocking the activity of dopamine on the D2 receptors, on the post-synaptic cholinergic nerves and by inducing the liberation of acetylcholine in the myenteric plexus. It also inhibits the hydrolysis of the released acetylcholine with the help of acetylcholinesterase.
Itopride is an acetylcholinesterase (AChE) inhibitor and D2 dopamine receptor antagonist. Itopride is used as a gastroprokinetic agent.
N2001 Neostigmine bromide ≥98% (HPLC and titration), powder Reversible inhibitor of acetylcholinesterase that is similar to eserine, but does not cross the blood-brain barrier.
N2126 Neostigmine methyl sulfate Reversible inhibitor of acetylcholinesterase that is similar to eserine, but does not cross the blood-brain barrier.
P9797 Pyridostigmine bromide Acetylcholinesterase inhibitor.
Pyridostigmine bromide inhibits acetylcholine esterase and is membrane impermeable. It is used as a preventive medicine in chemical warfare. Pyridostigmine bromide is a carbamate compound comprising quaternary amine structure. It displays low absorption at the gastrointestinal tract. Sustained release of pyridostigmine is recommended for improving its bioavailability in treating myasthenia gravis.
SML0967 TAE-1 ≥98% (HPLC) TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. TAE-1 is a sym-triazine with dual activity against Alzheimer′s disease. TAE-1 inhibits cholinesterases AChE and BuChE with IC50 values of 0.3 and 3.9 μM. Studies using TAE-1 on differentiated human SH-SY5Y neuronal cells have suggested that it can stimulate synapse formation and promote the differentiation of human neurons, increasing neurite extension.