Estrogens are a group of steroid hormones that control the development and maintenance of an individual’s feminine characteristics. Natural estrogens exist in men as well as women, and are found in higher amounts in women, especially in those of reproductive age. The primary female sex hormones include estrone, estradiol, and estriol. Estrogens enter the cell and activate estrogen receptors on the nuclear membrane that in turn initiate the expression of genes. Estrogens are produced primarily in the ovaries and, during pregnancy, the placenta. Some estrogens are produced in smaller amounts by other tissues such as the liver, adrenal glands, and the breasts. Fat cells also produce estrogen. In females, the synthesis of estrogens starts by the creation of androstenedione (an androgen) from cholesterol.

Estrogen imbalances can create a variety of disorders, both sexual and nonsexual. Sigma-Aldrich products support research on estrogens and their effects on the body. These products include hormones, hormone precursors, and receptor antagonists.

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PZ0018 Bazedoxifene acetate ≥98% (HPLC)
H5915 2,3-Bis(4-hydroxyphenyl)propionitrile ≥98% (HPLC)
SML1376 BTC ≥95% (HPLC)
SML1642 DHED ≥98% (HPLC)
D2571 DPPE hydrochloride ≥98% (HPLC)
D3946 DY 131 ≥98% (HPLC)
SML0719 Enclomiphene hydrochloride ≥96% (HPLC)
E3625 16-Epiestriol ≥93% (HPLC)
E8126 Equilin
PZ0183 ERB-041 ≥98% (HPLC)
SML1523 Estetrol ≥98% (HPLC)
E8750 α-Estradiol powder, ≥98% (TLC)
E8875 β-Estradiol ≥98%
E2758 β-Estradiol BioReagent, powder, suitable for cell culture
E2257 β-Estradiol powder, γ-irradiated, suitable for cell culture
E1132 β-Estradiol analytical standard
E7879 β-Estradiol 17-acetate ≥99%
E5630 β-Estradiol 6-(O-carboxy­methyl)oxime: BSA
E6507 β-Estradiol 6-(O-carboxy­methyl)oxime: BSA fluorescein iso­thio­cyanate conjugate
E8004 β-Estradiol 17-cypionate
E2127 β-Estradiol 3-(β-D-glucuronide) sodium salt
E1127 β-Estradiol 17-(β-D-glucuronide) sodium salt
E2128 β-Estradiol 3-(β-D-glucuronide) 17-sulfate dipotassium salt
K1001 β-Estradiol-6-one
K2126 β-Estradiol-6-one 6-(O-carboxymethyloxime)
E9505 β-Estradiol 3-sulfate sodium salt ≥93%
E1631 β-Estradiol 17-valerate ≥98%
E4389 β-Estradiol-Water Soluble BioReagent, suitable for cell culture
E0407 Estramustine sodium phosphate
E1253 Estriol ≥97%
E1877 Estriol 16α-(β-D-glucuronide) ≥97%
E6375 Estriol 3-sulfate sodium salt
E0160 Estrogen Receptor human membrane suspension
E1528 Estrogen Receptor-α human ≥80% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution
E1653 Estrogen Receptor-β human ≥80% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution
E9750 Estrone ≥99%
E1752 Estrone 3-(β-D-glucuronide) sodium salt
E9875 Estrone 3-methyl ether ≥97% (HPLC)
E9145 Estrone 3-sulfate potassium salt ≥98%
E0251 Estrone 3-sulfate sodium salt contains ~35% Tris as stabilizer
E2661 Estropipate ≥98% (HPLC), powder
E7263 Ethynodiol diacetate
E4876 17α-Ethynylestradiol ≥98%
E7887 17α-Ethynylestradiol 3-cyclopentyl ether
SML1609 Ferutinin ≥98% (HPLC)
I4409 Fulvestrant >98% (HPLC)
G6173 GSK 4716 ≥98% (HPLC)
H3131 2-Hydroxyestradiol ≥95% (HPLC)
H6012 4-Hydroxyestrone ≥90% (HPLC)
SML1026 Lasofoxifene tartrate ≥98% (HPLC)
M7068 MPP dihydrochloride hydrate ≥97% (HPLC), white powder
SML0996 Ospemifene ≥98% (HPLC)
SML1876 PaPE-1 ≥98% (HPLC)
SML1355 PHTPP ≥98% (HPLC)
R1402 Raloxifene hydrochloride solid
SML0941 Tibolone ≥98% (HPLC)
T7204 Toremifene citrate salt ≥98% (HPLC)
H6036 1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole powder, ≥98% (HPLC)
W1520 WAY-200070 ≥98% (HPLC)
X4753 XCT790 ≥98% (HPLC), solid
Z0292 α-Zearalanol ~98% (HPLC)
Z0417 β-Zearalanol ~98% (HPLC)
Z0167 Zearalanone
Z0166 α-Zearalenol