Corticosteroids are a class of drugs based on hormones formed in the adrenal gland or derived synthetically. They are created from cholesterol and divided into two major groups: glucocorticoids and mineralocorticoids. Common glucocorticoids are cortisol (hydrocortisone), prednisolone, dexamethasone, and corticosterone. An important mineralocorticoid in humans is aldosterone. Corticosteroids influence a wide range of physiological processes, including stress response, immune response, regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. The secretion of these hormones increases during stress related to anxiety and severe injury. Corticosteroids are often prescribed for severe allergies, skin problems, asthma, and arthritis. They are also used to help prevent organ rejection in transplant recipients. Chronic overproduction of these substances is associated with various disorders, such as Cushing′s syndrome.

For researchers interested in corticosteroids and their effects, Sigma-Aldrich has synthetic corticosteroids, corticosteroid-based drugs, and chemicals that affect the synthesis and metabolism of corticosteroids.

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SML1480 Alclometasone dipropionate ≥98% (HPLC)
A9477 Aldosterone ≥95% (HPLC)
B7005 Betamethasone ≥98%
B1152 Betamethasone 17,21-dipropionate
B7652 Betamethasone 21-phosphate disodium ≥97%
B0515 Betamethasone 17-valerate
C7287 Canrenoic acid potassium salt powder
SML1497 Canrenone ≥97% (HPLC)
C2505 Corticosterone ≥92%
C8784 Anti-Corticosterone antibody produced in rabbit whole antiserum, lyophilized powder
C174 Corticosterone: HBC complex free flowing powder
C8409 Anti-Cortisol antibody produced in rabbit whole antiserum, lyophilized powder
C2755 Cortisone ≥98%
C3130 Cortisone 21-acetate ≥99%
SML0123 Deflazacort ≥98% (HPLC)
D7000 Deoxycorticosterone acetate
P9521 21-Deoxycortisol
D6288 6α,9α-Difluoroprednisolone 21-acetate 17-butyrate ≥98%
E6657 Eplerenone ≥98% (HPLC)
F6127 Fludrocortisone acetate ≥98%
SML0099 Fluocinonide ≥98% (HPLC)
F9428 Fluticasone propionate ≥98% (HPLC), powder
H0888 Hydrocortisone BioReagent, suitable for cell culture
H0135 Hydrocortisone γ-irradiated, powder, BioXtra, suitable for cell culture
H4001 Hydrocortisone ≥98% (HPLC)
H4126 Hydrocortisone 21-acetate ≥98% (HPLC)
H5270 Hydrocortisone 17-butyrate
H6635 Hydrocortisone 3-(O-carboxymethyl)oxime
H2270 Hydrocortisone 21-hemisuccinate sodium salt powder, BioReagent, suitable for cell culture
H4881 Hydrocortisone 21-hemisuccinate sodium salt ≥90% (HPLC)
H0396 Hydrocortisone-Water Soluble BioReagent, suitable for cell culture
H6779 6α-Hydroxycortisol ≥98%
H6904 6β-Hydroxycortisol ≥98%
SML0547 Loteprednol Etabonate ≥98% (HPLC)
M0639 6α-Methylprednisolone ≥98%
M3781 6α-Methylprednisolone 21-hemisuccinate sodium salt lyophilized powder
M2696 Metyrapone ≥98% (HPLC), solid
SML1579 MS4 ≥98% (HPLC)
PZ0031 PF-03882845 ≥98% (HPLC)
P6004 Prednisolone ≥99%
P8650 Prednisolone 21-acetate ≥97%
P4153 Prednisolone 21-hemisuccinate sodium salt ≥90%, powder
P6254 Prednisone ≥98%
P0543 5-Pregnen-3β-ol-20-one-16α-carbonitrile ≥97%
SML0141 Trilostane ≥98% (HPLC)