Calcium Antagonists

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A3168 N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride analytical standard, for drug analysis A calmodulin antagonist; inhibits Ca2+/calmodulin activated phosphodiesterase and myosin light chain kinase.
A3281 N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) is a calmodulin antagonist. It can prevent calcium-dependent protein kinase, that is sensitive to phospholipid.
SML0657 N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride ≥98% (HPLC) N-(6-Aminohexyl)-1-naphthalenesulfonamide (W-5) is a cell permeable calmodulin antagonist that binds directly to the enzyme.
SML1386 Calindol hydrochloride ≥98% (HPLC) Calindol is a calcimimetic Ca Sensing Receptor (CaSR) agonist. It is a positive allosteric modulator (PAM) with an EC50 value of 1 μM and a maximum stimulation of 130% of the 10mM Ca2+ activation in triggering PI hydrolysis.
C3930 Calmidazolium chloride solid Inhibitor of calmodulin-regulated enzymes. It is also believed to directly block calcium channels in smooth muscle cells.
C4926 Calmodulin-dependent Protein Kinase II fragment 290-309 ≥97% (HPLC) Potent Ca2+/calmodulin-dependent protein kinase II inhibitor.
C1619 CGS-9343B ≥98% (HPLC), powder CGS-9343B is a selective calmodulin antagonist with minimal protein kinase C or antidopaminergic activity. CGS-9343B is a potent inhibitor of calmodulin-activated (Type I) phosphodiesterase activity with IC50 in the nanomolar range.
C8138 Chlorpromazine hydrochloride ≥98% (TLC) Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.
Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.
F1428 Fenvalerate ≥97% Fenvalerate has good insecticidal potential and is less toxic to animals. It might cause endocrine disruption and reproductive dysfunction in humans. Metabolism of fenvalerate includes oxidation, ester cleavage and conjugation reaction. It is stable at pH 5 and 7, while it gets hydrolyzed at pH 9. In rat models it is found to hinder the action of mitochondrial enzymes.
Fenvalerate is a type II semi-synthetic pyrethrin, which acts as a potent inhibitor of calcineurin (protein phosphatase 2B). This inhibitory action results in cellular hyperexcitability by causing non-mutated calcium channels to remain open for an extended period of time allowing an abundance of Ca2+ to enter the cell.
Type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B).
M2272 Melittin from honey bee venom ≥85% (HPLC) Binds calmodulin in a Ca2+-dependent manner; inhibits Na+-K+-ATPase.
Melittin acts as an anti-coagulating protein by increasing the time of blood clotting in vitro. Melittin inhibits the activity of S100 calcium-binding protein B (S100B) and plays a vital role in Epilepsy treatment.
SML0362 NPS2143 hydrochloride ≥98% (HPLC) NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.
NPS2143 is a selective calcium-sensing receptor (CaR) antagonist. The compound blocks increases in cytoplasmic calcium concentrations with an IC50 of 43 nM, and stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells over a wide range of extracellular calcuim concentrations.
SML1872 ORM-3819 ≥98% (HPLC) ORM-3819 is a potent inotropic agent that binds to cardiac troponin C (cTnC) and sensitizes heart to Ca2+. Also, ORM-3819 is a selective and potent inhibitor of PDE III. ORM-3819 exhibits positive inotropic effects through Ca2+-sensitization and selective inhibition of PDE III. ORM-3819 was effective in vivo dog model of myocardial stunning.
T4577 Terodiline hydrochloride ≥98% (HPLC), solid Terodiline hydrochloride is a non-selective calcium channel antagonist with anticholinergic and vasodilatory activity.
Terodiline is known to increase corrected QT interval (QTc) and decrease resting heart rate in elderly patients. Furthermore, terodiline hydrochloride has been linked to cardiac arrhythmias1.
T8516 Trifluoperazine dihydrochloride ≥99%, powder Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
Trifluoperazine dihydrochloride is useful in treating schizophrenia, disturbed behavior, severe anxiety, nausea and vomiting.
SML0717 W-13 ≥98% (HPLC) W-13 has also been shown to inhibit the transcytosis of IgA, recycling of transferrin and overall alter the endocytic pathway in Madin-Darby canine kidney cells.
W-13 is a membrane-permeable calmodulin antagonist. W-13 inhibits Ca2+-calmodulin-dependent phosphodiesterase and has been shown to inhibit the EGF-dependent activation of EGFR in N7xHERc fibroblasts.