DNA Synthesis Inhibitors

Many of the regulatory feedback pathways are deregulated in cancer cells, resulting in the loss of genetic control of DNA synthesis. Small molecules that target various aspects of DNA synthesis are important because these compounds can uncover how the protein signaling pathways at work in cancer biology are regulated. Sigma offers therapeutics such as Bleomycin (Cat. No. B5507) which binds to DNA, causing scissions at specific base sequences, and Hydroxyurea (Cat. No. H8627) which inactivates ribonucleoside reductase to block DNA synthesis. Other small molecules available at Sigma include toposiomerase inhibitors (Cytosine arabinofuranoside – Cat. No. C1768), folic acid antagonists (Amethopterin – Cat. No. A1784), and antineoplastic agents (Ancitabine – Cat. No. A8598 and Tegafur – Cat. No. T7205).

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A1784 Aminopterin powder
A8598 Ancitabine hydrochloride
B8416 Bleomycin sulfate from Streptomyces verticillus 1.5-2.0 units/mg solid, BioReagent, suitable for cell culture
B5507 Bleomycin sulfate from Streptomyces verticillus crystalline, 1.5-2.0 U/mg
B5002 5-Bromo-2′-deoxyuridine ≥99% (HPLC)
SML0653 Capecitabine ≥98% (HPLC)
SML1281 Capecitabine Ready Made Solution 10 mg/mL in DMSO
C1494 Carmofur ≥98% (HPLC), powder
C1768 Cytosine β-D-arabinofuranoside crystalline, ≥90% (HPLC)
C6645 Cytosine β-D-arabinofuranoside hydrochloride crystalline
F8791 5-Fluoro-5′-deoxyuridine
H8627 Hydroxyurea 98%, powder
I1656 Idarubicin hydrochloride solid
M8407 Methotrexate hydrate powder, BioReagent, suitable for cell culture, ≥98% (HPLC)
A6770 Methotrexate hydrate ≥98% (HPLC), powder
M0503 Mitomycin C from Streptomyces caespitosus powder, contains NaCl as solubilizer
SML1736 Nelarabine ≥98% (HPLC)
P9564 Phleomycin from Streptomyces verticillus powder
T7205 Tegafur ≥98% (HPLC), powder
P4413 N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine