Leukotrienes are a subset of eicosanoids, each containing 20 carbons and a carboxylic acid moiety. They are important mediators of immune and inflammatory responses, especially in asthma and allergies, and may also play a role in arthritis, cardiovascular and other diseases. Leukotrienes are derivatives of essential fatty acids, formed by the action of 5-lipoxygenase (5-LOX) on arachidonic acid. They are often produced in response to an allergen, and generally with histamine. They act locally, as autocrine or paracrine signalers. Leukotrienes are divided into two classes - leukotriene B4 (highly potent inflammatory) and cysteinyl-substituted (sulphidopeptide). Sigma offers a host of leukotriene inhibitors for your research, including therapeutics and drug candidates.

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Molecular Formula

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B9680 Bay u9773 ≥98% (HPLC), oil C27H36O5S 472.6
C6239 Cinalukast ~98% (HPLC) C23H28N2O3S 412.6
C1017 Citrinin from Penicillium citrinum, ≥98% (HPLC) C13H14O5 250.3
F1179 FPL-55712 ≥97% (HPLC), solid C27H29O9Na 520.5
L0517 Leukotriene B4 ~100 μg/mL in ethanol, ≥97% C20H32O4 336.5
L5011 Leukotriene D4 ~50 μg/mL (in methanol/ammonium acetate buffer, 70:30, pH 5.6), ≥97% C25H40N2O6S 496.7
M7571 MK-571 sodium salt hydrate ≥95% (HPLC) C26H26ClN2NaO3S2 · xH2O 537.1
SML0101 Montelukast sodium hydrate ≥98% (HPLC) C35H35ClNO3S·Na · xH2O 608.2
P0080 Pranlukast hemihydrate ≥98% (HPLC), white solid C27H23N5O4 · 0.5 H2O 490.5
SML1704 Quininib ≥98% (HPLC) C17H13NO 247.3
R5523 REV 5901 C22H25NO2 335.4
Z4152 Zafirlukast ≥98% (HPLC) C31H33N3O6S 575.7