Lipoxygenase (LOX) are enzymes that catalyze the addition of oxygen to polyunsaturated fatty acidscontaining a cis, cis-1,4- pentadiene structure. The most common analogs are 5-LOX, 8-LOX, 12-LOX, and 15-LOX, with the number indicating at which carbon the oxygen is inserted. LOXs are commonly found in animals, plants, fungi and bacteria, where they create signaling molecules or induce structural or metabolic changes in cells, and are thus targets for control by inhibition. Arachidonate 5-lipoxygenase (5-LO) transforms essential fatty acids (EFAs) into leukotrienes, and selective inhibitors are currently being investigated as therapeutics for coronary artery disease (CAD), cancer, and asthma. Many lipoxygenase (LO)-catalysed metabolites affect the development and progression of human cancers, so LOX inhibitors are promising therapeutic targets and many are available at Sigma.

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B7559 BW A4C ≥98% (HPLC)
B4558 BW B70C >98% (HPLC), solid
SML0105 Cinnamyl-3,4-dihydroxy-α-cyanocinnamate ≥98% (HPLC)
SML0187 CJ-13610 ≥98% (HPLC)
D2154 5,6-Dehydroarachidonic acid ≥98%, ethanol solution
E2011 cis-5,8,11,14,17-Eicosapentaenoic acid ≥99%
E6627 cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt ≥99% (capillary GC)
E1768 5,8,11,14-Eicosatetraynoic acid ≥97%
L1920 LY255283 ≥98% (HPLC), powder
M4531 Meclofenamic acid sodium salt
SML0499 NCTT-956 ≥97% (NMR)
N0630 Niflumic acid
N5023 Nordihydroguaiaretic acid ≥90% (HPLC), from Larrea divaricata (creosote bush)
O5636 9,12-Octadecadiynoic acid ≥98%
P4620 PD 146176 ≥98% (HPLC), solid
Z4277 Zileuton ≥98% (HPLC)