Cyclooxygenases (COX) are a class of enzymes that convert arachidonic acid (AA) to hydroperoxy endoperoxide prostaglandin G2 (PGG2) and then reduce PGG2 to prostaglandin H2 (PGH2). There are three isoenzymes of COX: COX-1 (normally present in the gastrointestinal tract), COX-2 (involved in inflammation, fever, pain, cancers, Alzheimer’s disease) and COX-3. Sigma offers nonselective and specific COX inhibitors for your research. Our collection of small molecules includes nonsteroidal antiinflammatory drugs (NSAIDs)as well as approved therapeutics and drug candidates.

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A5376 Acetylsalicylic acid ≥99.0%
SML1475 Ampiroxicam ≥98% (HPLC)
SML0289 Bromfenac sodium ≥98% (HPLC)
SML1713 Carprofen ≥97% (HPLC)
SML0530 Clonixin ≥98% (HPLC)
SML0994 DFU ≥98% (HPLC)
D6899 Diclofenac sodium salt
E0516 Etodolac
F8514 Flurbiprofen cyclooxygenase inhibitor
F7553 FR 122047 hydrochloride ≥98% (HPLC), powder
SML1452 Ibufenac ≥95% (HPLC)
I4883 Ibuprofen ≥98% (GC)
I110 Ibuprofen
SML1842 Ibuprofen Arginate ≥98% (HPLC)
I7904 Indomethacin heptyl ester methyl acetate solution, ≥98% (HPLC)
K1136 Ketorolac tris salt ≥99%, crystalline
SML0338 Lornoxicam ≥98% (HPLC)
M3935 Meloxicam sodium salt hydrate ≥98% (HPLC)
SML1488 Metamizole sodium hydrate ≥98% (HPLC)
284785 (S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid 98%
M9190 Methyl 14(S),15(S)-epoxy-11(R,S)-hydroxy-(5Z,8Z,12E)-eicosatrienoate ≥95% (HPLC), hexane solution
M8940 Methyl 14(S),15(S)-epoxy-13(R)-hydroxy-(5Z,8Z,11Z)-eicosatrienoate ≥95% (HPLC), hexane solution
M1275 Naproxen sodium 98.0-102.0%
SML1669 NCX 4016 ≥98% (HPLC)
SML0414 NCX 4040 ≥98% (HPLC)
SML0288 Nepafenac ≥98% (HPLC)
N1016 Nimesulide
N194 NS-398 ≥98% (HPLC), solid
P0740 N-(2-Phenylethyl)indomethacinamide
P5654 Piroxicam ≥98% (TLC)
SML1423 Pranoprofen ≥98% (HPLC)
P0865 N-(3-Pyridyl)indomethacinamide ≥98%
SML0613 Rofecoxib ≥98% (HPLC)
SML0070 Salsalate ≥98% (HPLC)
PZ0106 SC-236 ≥98% (HPLC)
S2064 SC-560 ≥98% (HPLC)
PZ0139 SC-58125 ≥98% (HPLC)
SML1495 Suprofen ≥98% (HPLC)
PZ0196 Tenidap ≥97% (HPLC)
T6580 Triflusal ≥98% (HPLC), powder
SML0310 Tryptanthrin ≥98% (HPLC)
PZ0179 Valdecoxib ≥98% (HPLC)
V2889 Valeryl Salicylate ≥98% (HPLC)
W0769 Wogonin hydrate ≥98% (HPLC), solid