Cell Cycle Regulators
The cell cycle controls replication and apoptosis, prevents uncontrolled cell division (tumor formation), and may involve detection and repair of damage to DNA. A conserved set of cyclin-dependent protein kinases (Cdks) initiate or regulate events through phosphorylation of intracellular proteins, thus controlling cell cycle progression, terminal differentiation, and apoptosis. Cdks bind to cyclins and form the maturation-promoting factor which phosphorylates multiple proteins at different stages of the cell cycle. Sigma offers a host of cell cycle regulators such as antimitotics, mitotic inhibitors, and cytokinesis inhibitors. Other small molecules available include DNA polymeraseinhibitors, apotosis inducers, antineoplastic agents, and antimetabolites. These compounds are valuable for better understandingcell cycle regulation, and carcinogenesis (oncogenesis, tumorigenesis).

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E1408 14-3-3 Eta histidine-tagged human recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
    • S7323 14-3-3 Sigma histidine-tagged human recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
    • T0953 14-3-3 Tau/Theta histidine-tagged human recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
    • Z3402 14-3-3 Zeta, histidine-tagged human recombinant, expressed in E. coli, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
    • PZ0268 AG-17724 ≥98% (HPLC)
    • 171536 AMPK (α1/β1/γ1), His•Tag, Human, Recombinant, S. frugiperda AMPK (α1/β1/γ1), His•Tag, Human, Recombinant, is a full length enzyme. Consists of subunits A1, B1, & G1, each fused at the C-terminus to a His•Tag sequence & co-expressed in S. frugiperda.
    • 171539 AMPK (α2/β1/γ1), His•Tag, Human, Recombinant,S. frugiperda
    • 346101-M Androgen Receptor, His•Tag, Human, Recombinant, S. frugiperda Androgen Receptor, His•Tag, Human, Recombinant, consists of androgen receptor fused at the N-terminus to a Flag-Tag sequence and at the C-terminus to His•Tag sequence, expressed in S. frugiperda.
    • 176872 Angiotensin Converting Enzyme-2, His•Tag, Human, Recombinant, NSO Cells
    • SML1503 Apcin ≥98% (HPLC)
    • A0781 Aphidicolin from Nigrospora sphaerica ≥98% (HPLC), powder
    • SML1427 AZ3146 ≥98% (HPLC)
    • PF125 BACE1, His•Tag, Human, Recombinant, NSO Cells Recombinant, human BACE-1 (amino acids 1-460) fused at the C-terminus to a His•Tag sequence and expressed in NSO cells. Supplied as a mixture of ~68-70 kDa proenzyme and ~65-67 kDa mature enzyme.
    • PF126 Bcl-2, C-Terminal Truncated, His•Tag, Human, Recombinant, E. coli Recombinant, human Bcl-2 without the 17 amino acid mitochondrial targeting sequence at the C-terminus, fused to a His•Tag sequence, and expressed in E. coli.
    • SRP5167 BCR (1-695), GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SML1925 Bepristat 2a hydrochloride ≥95% (HPLC)
    • B1186 Binucleine 2 ≥97% (HPLC)
    • B0560 (−)-Blebbistatin solid, synthetic
    • B6688 BMS 493 ≥98% (HPLC)
    • SML0560 BRACO19 hydrochloride ≥96% (HPLC)
    • 208670 Calmodulin, His•Tag Human, Recombinant Calmodulin, His•Tag Human, Recombinant, is a full-length, recombinant human calmodulin fused to a His•Tag sequence at the N-terminus. Contains four functional Ca2+-binding sites.
    • 217460 Cardiogenol C - CAS 671225-39-1 - Calbiochem A cell-permeable pyrimidine compound that potently induces the differentiation of ESCs (embryonic stem cells) into cardiomyocytes (EC₅₀ = 100 nM) without significant cytotoxic effect even at concentrations as high as 25 µM.
    • 219461 Cathepsin K, His•Tag, Human, Recombinant, E. coli Cathepsin K, His•Tag, Human, Recombinant, E. coli, CAS 94716-09-3, of the papain superfamily of cysteine proteinases plays a role in osteoclast-mediated bone resorption and collagen degradation.
    • 219467 Cathepsin V, His•Tag, Human, Recombinant, NSO Cells Cathepsin V, His•Tag, is a recombinant human procathepsin V (aa 18-334) fused at the N-terminus to a CD33 signal sequence (aa 1-16) & at C-terminus to a His•Tag sequence & expressed in NSO cells.
    • 420358 CBFβ Activator, Kartogenin - Calbiochem The CBFβ Activator, Kartogenin modulates the biological activity of CBFβ. This small molecule/inhibitor is primarily used for Biochemicals applications.
    • SML0988 CCCI-01 ≥98% (HPLC)
    • SRP5005 CDC25A, active, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5006 CDC25B, active, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5007 CDC25C, active, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5174 CDC42, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5342 CDK2, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5175 CDKN3, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • 5.06028 Cell Proliferation Inducer, WS3 - Calbiochem
    • SML1448 Cycloastragenol ≥98% (HPLC)
    • D7802 Daidzein ≥98%, synthetic
    • D4921 Destruxin A from Metarrhizium anisopliae ≥98% (HPLC)
    • SML0905 Dimethylenastron ≥98% (HPLC)
    • 317639 Dipeptidylpeptidase IV, His•Tag , Human, Recombinant, S. frugiperda DPPIV is involved in many cellular processes such as activation of cytokines, differentiation, and cell-matrix interactions. Inhibition of DPPIV has been reported to be an effective treatment for type II diabetes.
    • 371206 Dkk-1, His•Tag , Mouse, Recombinant Dkk-1, His•Tag, Mouse, Recombinant, consists of amino acids 30-272, fused at the C-terminus to a His•Tag sequence, and expressed in NS0-dervied mouse myeloma cells.
    • SML0483 DpC ≥98% (HPLC)
    • 516678-M 4EBP1, His•Tag, Human, Recombinant, S. frugiperda 4EBP1, His•Tag, Human, is a full-length, human recombinant 4EBP1 fused at the N-terminus to a His•Tag sequence and expressed in S. frugiperda insect cells.
    • E3656 (−)-Epothilone A from Sorangium cellulosum, >95% (HPLC), solid
    • E2656 (−)-Epothilone B from Sorangium cellulosum, ≥98% (HPLC)
    • F3680 10058-F4 ≥98% (HPLC), solid
    • F6627 5-Fluorouracil ≥99% (HPLC), powder
    • 344146 FPTase, GST-Fusion, His•Tag, Rat, Recombinant, E. coli FPTase, GST-Fusion, His•Tag, Rat, Recombinant, E. coli, is composed of an74 kDa α- and 47 kDa β-subunit. The α-subunit is expressed as a GST-fusion construct with an N-terminal His•Tag sequence.
    • SRP5182 FRS3, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • G3798 10074-G5 ≥98% (HPLC)
    • 345749 GDF-8 Propeptide, His•Tag , Mouse, Recombinant GDF-8 Propeptide, His•Tag, Mouse, Recombinant, consists of amino acids 25-285, fused at the C-terminus to a His•Tag sequence, and expressed in NS0-derived mouse myeloma cells.
    • G6423 Gemcitabine hydrochloride ≥98% (HPLC)
    • 345852 Geranylgeranyltransferase I, GST-Fusion, His•Tag, Rat, Recombinant, E. coli Geranylgeranyltransferase I, GST-Fusion, His•Tag, Rat, Recombinant, E. coli, contains a 74 kDa α- & 43 kDa β-subunit. The α-subunit is expressed as a GST-fusion construct with an N-terminal His•Tag.
    • 361524 GSK-3β, His•Tag, Human, Recombinant, E. coli GSK-3β, His-Tag, Human, Recombinant, E. coli, is a dual specificity kinase that plays important roles in insulin- and Wnt-mediated signaling. It is inactivated by phosphorylation at Ser9.
    • SRP5153 14-3-3 ε, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5155 14-3-3 ζ, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5157 14-3-3 θ, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5159 14-3-3 σ , GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • 70796-M His•Tag Monoclonal Antibody Novagen®
    • 382184 Histone Deacetylase 8, His•Tag, Human Recombinant, S. frugiperda Histone Deacetylase 8, His•Tag, Human Recombinant, S. frugiperda, is a full length HDAC8 fused to His-Tag at the C-terminus. Useful in the study of HDAC8 regulation and for inhibitor screening.
    • H4914 Honokiol ≥98% (HPLC), powder
    • B6312 14-3-3 Beta histidine-tagged human recombinant, expressed in E. coli, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
    • 407255 IGFBP-rp1/IGFBP-7, His-Tag, CF, Mouse, Recombinant
    • SML0341 Importazole ≥98% (HPLC)
    • I0404 Indirubin-3′-oxime ≥98% (HPLC), solid
    • SML1911 INI-43 ≥98% (HPLC)
    • 407241 Insulin Degrading Enzyme, His•Tag, Rat, Recombinant, S. frugiperda
    • I0763 N9-Isopropylolomoucine ≥98% (HPLC)
    • K3888 Kenpaullone ≥98%
    • SML0559 LDN193189 hydrochloride ≥98% (HPLC)
    • SML1414 Liproxstatin-1 >98% (HPLC)
    • 440319 Lumican, His•Tag , CF, Mouse, Recombinant
    • 4403-M Lysozyme, Chicken Egg White Native, chicken egg white lysozyme. Inhibits the biological activity of lipopolysaccharides from periodontopathic bacteria.
    • 454849 MAP Kinase 1, His•Tag, Human, Recombinant, E. coli
    • 454854 MAP Kinase 2, His•Tag, Human, Recombinant, E. coli
    • SML0810 MHY1485 ≥95% (HPLC)
    • M0253 L-Mimosine from Koa hoale seeds ≥98%
    • M3047 Mizoribine ≥98% (TLC)
    • SML0407 ML 141 ≥98% (HPLC)
    • 444248 MMP-13, Proenzyme, His•Tag, Human, Recombinant, S. frugiperda
    • M8515 Monastrol ≥98% (HPLC), solid
    • SRP5102 Mortalin (47-end), GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SML0047 MoTP ≥98% (HPLC)
    • SML1477 MPI-0479605 hydrochloride ≥98% (HPLC)
    • M3949 MST-312 ≥98% (HPLC)
    • M9823 Myra A hydrochloride ≥98% (HPLC), powder
    • SRP5103 NCK, His tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SML1659 NCT-503 ≥98% (HPLC)
    • SML1671 NCT-503 Inactive Control ≥98% (HPLC)
    • N0164 Necrostatin-5 ≥98% (HPLC), solid
    • N9653 Netropsin dihydrochloride from Streptomyces netropsis, ≥98% (HPLC and TLC), powder
    • 480703-M Neurodazine - CAS 937807-66-4 - Calbiochem A cell-permeable trisubstituted imidazole compound that induces neurogenesis of non-pluripotent C2C12 myoblasts as well as cells derived from mature human skeletal muscle cultures (2 µM for 7-10 days).
    • 480743 Neuronal Differentiation Inducer III - CAS 832115-62-5 - Calbiochem A cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 µM) in various stem/progenitor cells.
    • 480748 Neuronal Differentiation Inducer, Isobavachin - Calbiochem A cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM.
    • 480746-M Neuronal Differentiation Inducer IV - Calbiochem A cell-permeable quinoxaline compound that is shown to induce neuronal differentiation in PC12 and rat MSC (mesenchymal stem cell) cultures with high efficiency.
    • SRP5105 NFKB2 (1-454), GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SML1620 NGI-1 ≥95% (HPLC)
    • N8914 NSC308848 ≥98% (HPLC), powder
    • N3414 NSC348884 hydrate
    • N4286 NU2058 >98% (HPLC)
    • O0886 Olomoucine ≥98% (HPLC)
    • 499260 Osteopontin, His•Tag, Mouse, Recombinant, Mouse
    • SRP3134 p16-INK-4a human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture
    • SRP3135 p16-INK-4a TAT human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture
    • SRP5106 p18INK4C, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5107 p19INK4D, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5108 p21CIP1, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5109 p27KIP1, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5111 p33ING1, His tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5112 p63, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SML0838 PACMA 31 ≥98% (HPLC)
    • SML0726 Panepoxydone from Lentinus conatus, ≥95% (HPLC)
    • SRP4835 PCNA human recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE), ≥90% (HPLC)
    • SML0730 PCNA-I1 ≥98% (HPLC)
    • 521270 PDK1, His•Tag, Human, Recombinant, S. frugiperda
    • 524739 Phosphodiesterase 10A2, His•Tag, Human, Recombinant, S. frugiperda
    • 524731 Phosphodiesterase 4A4, His•Tag, Human, Recombinant, S. frugiperda
    • 524736 Phosphodiesterase 4B2, His•Tag, Human, Recombinant, S. frugiperda
    • 524733 Phosphodiesterase 4D3, His•Tag, Human, Recombinant, S. frugiperda
    • 524734 Phosphodiesterase 3B, His•Tag, Human, Recombinant, S. frugiperda
    • B7688 PiB ≥98% (HPLC)
    • 539569 PP2C, α-Isoform, His•Tag, Human, Recombinant, E. coli
    • 530006 Prion Protein, His•Tag, Human, Recombinant, E. coli
    • SRP5119 PRKAR1A, His tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5120 PRKAR1B, His tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • 481409 PTEN, His•Tag and S•Tag, Human Recombinant, S. frugiperda
    • 540220 Purmorphamine - CAS 483367-10-8 - Calbiochem A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC₅₀ = 1 µM).
    • P4484 Purvalanol A ≥98% (HPLC), powder
    • SML0481 Qc1 ≥98% (HPLC)
    • SML1676 R9-caPep trifluoroacetate salt ≥95% (HPLC)
    • SRP5121 RAC1, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5122 RAC2, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5123 RAC3, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • 553504 RAD51, His•Tag, Pneumocystis carinii, Recombinant, E. coli
    • SRP5124 Rb (48-378), GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP0256 RB Active human recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
    • R0382 Retrorsine ≥90% (HPLC)
    • SRP5126 RGS1, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5127 RhoA, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5128 RhoC, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5129 RhoD, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • R7772 Roscovitine ≥98% (TLC)
    • R7532 RRD-251 hydrochloride ≥98% (HPLC)
    • SML1121 SB743921 hydrochloride ≥98% (HPLC)
    • M6680 Se-(Methyl)selenocysteine hydrochloride ≥95% (TLC)
    • 565834 sFRP-3, His•Tag , Mouse, Recombinant
    • 344300 sFRP-1 Inhibitor - CAS 915754-88-0 - Calbiochem The sFRP-1 Inhibitor, also referenced under CAS 915754-88-0, controls the biological activity of sFRP-1. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
    • SRP5130 SMAD1, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5131 SMAD2, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SML0440 Spautin-1 ≥98% (HPLC)
    • SRP5144 Stathmin, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • 569393 Stauprimide - CAS 154589-96-5 - Calbiochem A cell-permeable ESCs (Embryonic Stem Cells) EMT (Epithelial-Mesenchymal Transition) inducer that is reported to prime/sensitize human and murine ESC cultures for much more enhanced/efficient differentiation into progenitor cells of multiple lineages.
    • SML0794 T2AA hydrochloride ≥98% (HPLC)
    • 5.30961 TAZ Activator, IBS008738 - Calbiochem
    • T1443 TCPOBOP ≥98% (HPLC), solid
    • 76899 Temozolomide VETRANAL®, analytical standard
    • SML1127 Terpendole E ≥95% (HPLC)
    • SRP5145 TGFβR1 (80-end), GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SML1296 6-Thio-2′-Deoxyguanosine ≥97% (HPLC)
    • 614850 Topoisomerase I, His•Tag, Human, Wild Type, Recombinant, S. frugiperda
    • U3385 UA62784 ≥98% (HPLC)
    • SRP5152 14-3-3 α/β, untagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5154 14-3-3 ε, untagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5156 14-3-3 ζ, untagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5158 14-3-3 θ, untagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5160 14-3-3 σ, untagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • 681665 Wnt Agonist - CAS 853220-52-7 - Calbiochem The Wnt Agonist, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.
    • SRP5151 XIAP, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • X3628 XK469 ≥98% (HPLC), solid
    • SML0176 Z36 ≥98% (HPLC)