Cathepsins are enzymes (serine, cysteine or aspartyl proteases) that degrade other proteins or polypeptides, assisting with cellular turnover. They are found in a wide variety of cell types, and are mainly active under acidic conditions such as in lysosomes. Cathepsin inhibitors are involved in Alzheimer’s disease, arthritis, cancer, ebola, COPD, several types of eye disorder, periodontitis and stroke. Another lysosomal serine protease family is the granual-associated granzymes (GrA, GrB, GrC, GrH, GrK, GrM). Granzymes enter infected cells and cleave caspase, DNA or other substrates, causing a chain of events that leads to the apoptic cell death (apoptosis, programmed cell death, PCD) of infected cells. Peptides and small molecules that are granzyme inhibitors are used as both cancer therapeutics and antibiotics.

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C5732 CA-074 ≥99% (TLC)
C5857 CA-074 methyl ester ≥99% (TLC)
P0350 Procathepsin B Fragment 26-50, rat ≥95% (HPLC)
C9984 Z-Gly-Leu-Phe-chloromethyl ketone ≥90% (TLC), solid
C9109 Z-Phe-Phe-fluoromethyl ketone ≥98% (TLC), solid