Inositol Phosphates

Inositol phosphates are important intracellular second messengers in eukaryotic cells. Inositol, a cyclic molecule with six hydroxyl groups, forms the hydrophobic head group of membrane inositol phospholipids. The actions of lipid kinases and phosphatases on the inositol ring of inositol phospholipids generate a variety of phosphoinositol phospholipids. As a result of upstream signaling events, specific phospholipases are activated, cleave phosphoinositol phospholipids, and release intracellular inositol phosphate second messenger molecules.
The most studied inositol phosphate second messenger is inositol 1,4,5-trisphosphate (IP3). IP3 is released from phosphatidylinositol 4,5-bisphosphate (PIP2) by the action of phospholipase C-β and is responsible for the release of calcium ions from intracellular stores in the endoplasmic reticulum.

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P6990 1,2-Dipalmitoylphosphatidylinositol 3,4-diphosphate sodium salt ≥98%, solid
P7115 1,2-Dipalmitoylphosphatidylinositol 4,5-diphosphate triammonium salt ≥98%, solid
P4240 1,2-Dipalmitoylphosphatidylinositol 3,4,5-trisphosphate tetrasodium salt ≥98%
I5125 myo-Inositol ≥99%
I7508 myo-Inositol BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture
I8132 scyllo-Inositol ≥98%
I8636 D-myo-Inositol 1,3,4,5-tetrakis(phosphate) ammonium salt ≥95%
I131 D-myo-Inositol 1,3,4,5-tetrakis(phosphate) potassium salt
I9766 D-myo-Inositol 1,4,5-tris-phosphate trisodium salt
L9908 LY-294,002 hydrochloride solid, ≥98% (HPLC)
P1652 D-α-Phosphatidylcholine, dipalmitoyl ≥99%
P9763 L-α-Phosphatidylinositol 4,5-diphosphate sodium salt from bovine brain ≥98% (TLC)
P4725 L-α-Phosphatidyl-D-myo-inositol 3,4-diphosphate, dioctanoyl
P3584 L-α-Phosphatidyl-D-myo-inositol 4,5-diphosphate, dioctanoyl
P5578 L-α-Phosphatidyl-D-myo-inositol 3-monophosphate, dioctanoyl
P3953 L-α-Phosphatidyl-D-myo-inositol 3-monophosphate, dipalmitoyl
P7686 L-α-Phosphatidyl-D-myo-inositol 4-monophosphate, dipalmitoyl ammonium salt
P8615 Phosphoinositide 3-kinase p110γ human ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution
P6023 Phosphoinositides sodium salt from bovine brain
SRP4838 PTEN human recombinant, expressed in E. coli
Q4951 Quercetin ≥95% (HPLC), solid
SML1090 SMI481 ≥98% (HPLC)
W1628 Wortmannin from Penicillium funiculosum, ≥98% (HPLC and TLC)
W3144 Wortmannin, Ready Made Solution from Penicillium funiculosum, ≥95% (HPLC)
SML1806 YU142670 ≥98% (HPLC)