Guanylyl Cyclase Inhibitors

Guanylyl cyclases (also known as guanylate cyclases or guanyl cyclases) are a family of enzymes that convert guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP). Like cAMP, cGMP is an important secondary messenger that can be degraded by other enzymes called phosphodiesterases, which are themselves under various forms of regulation. Guanylyl cyclases include membrane-bound and soluble (nitric oxide-sensitive) forms, and are regulated by substances that include peptide hormones, bacterial toxins, free radicals, and intracellular molecules like calcium and adenine nucleotides. In response to calcium levels, guanylyl cyclase is stimulated and the resultant accumulation of cGMP regulates the complex G protein signaling cascades that help regulate physiological processes like vascular smooth muscle motility, intestinal fluid homeostasis, and retinal phototransduction. Inhibition of guanylyl cyclase therefore affects levels of cGMP and those physiological processes regulated by cGMP. Sigma-Aldrich offersa number of guanylyl cyclases inhibitors to aid research on these enzymes and their associated processes.

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A201 Acenaphthenequinone
A6563 6-Anilinoquinoline-5,8-quinone ≥95% (TLC), solid
B6684 Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt ≥98% (HPLC), powder
N211 NS 2028 solid
O3636 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one powder