Modulators for MDR/TAP Transporters

Domain Organization of Bile Salt Transporter (BSEP)
BSEP is a member of the MDR/TAP subfamily. Transporters of this subfamily have the general form of (TMD-ABC)2 (TMD, transmembrane domain; ABC, ATP-binding cassette) although there are half transporters. The TMDs are composed of six helixes buried in the lipid bilayer of plasma membrane and the ATP binding ABCs are exposed in the cytosol. The TMD helixes are envisioned to form channels spanning the plasma membrane. There is experimental evidence for multiple substrate binding sites associated with the TMDs. Half transporters form tight functional coupling in multimolecular complexes.

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B3251 Berberine chloride form
B3412 Berberine hemisulfate salt ≥95%
PZ0171 CP-100356 monohydrochloride >98% (HPLC)
SML0938 Dofequidar fumarate ≥98% (HPLC)
SML0486 Elacridar ≥98% (HPLC)
G4923 (E)-Guggulsterone ≥95% (HPLC), powder
SML0372 NSC23925 ≥98% (HPLC)
SML1897 NSC73306 ≥98% (HPLC)
P6490 PGP-4008
R1276 Reversin 121 ≥97% (HPLC), powder
R1401 Reversin 205 ≥98% (HPLC), film
S4400 Staurosporine from Streptomyces sp. ≥98% (HPLC), film
S5921 Staurosporine from Streptomyces sp. for molecular biology, ≥95% (HPLC)
S6942 Staurosporine solution from Streptomyces sp. Ready Made Solution, 1 mM in DMSO (100 μg/214 μL), 0.2 μm filtered
SML1790 Tariquidar ≥98% (HPLC)
SML0310 Tryptanthrin ≥98% (HPLC)
SML0572 Valspodar ≥98% (HPLC)
V106 R(+)-Verapamil monohydrochloride hydrate ≥98% (HPLC), powder
SML1044 Zosuquidar hydrochloride ≥98% (HPLC)