Fibroblast-like synoviocytes (type B synoviocytes) are found in the joints, where they produce glycoproteins that comprise most of the synovial fluid, essential for joint lubrication. As the name suggests, these cells are related to fibroblasts, sharing origins and markers with them.
During rheumatoid arthritis (RA), the joint becomes constantly inflamed, and, concurrently, synoviocytes acquire abnormal features and altered gene expression, contributing to tissue destruction. Although there is usually less inflammation in the joints of patients with osteoarthritis (OA), there are also signs of synoviocytes activation which may contribute to the disease progression. Arthritis research shows proinflammatory cytokines induce HFLS proliferation and stimulate their production of erosive enzymes like collagenase, aggrecanase, GM-CSF and metalloproteinases, contributing to cartilage degradation and joint destruction.
We offer three types of HFLS derived from joints of healthy donors and donors suffering from Osteoarthritis or Rheumatoid Arthritis. This cell combination provides a useful model for studying the differences between normal and pathological conditions of RA and OA, such as the expression and regulation of proteases and adhesion molecules.

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408-05A Human Fibroblast-Like Synoviocytes: HFLS, adult
408OA-05A Human Fibroblast-Like Synoviocytes-Osteoarthritis: HFLS-OA, adult