Insulin-like Growth Factors (IGF)

Insulin-like growth factors (IGF-I and IGF-II) are mitogenic and anabolic peptides structurally homologous to insulin. IGF-I and -II are single polypeptide chains of approximately 7.5 kDa comprised of 70 and 67 amino acid residues, respectively. IGF-I and -II share 70% homology in amino acid sequence, while IGF-I and proinsulin share 48% homology. Both IGFs are highly conserved between species, with 100% identity among human, bovine and porcine IGFs. Unlike insulin, IGF-I and -II are primarily involved in normal growth and development. Circulating IGF is mainly secreted from the liver and acts as an endocrine signal to distant cells. IGF-IR is a tyrosine kinase receptor with signal transduction pathways that include substrates IRS-1, IRS-2, Shc, and Grb10. IGF-IIR has anabolic functions (like IR) but also shows three distinguishing qualities concerned with growth: signals mitosis, maintains transformed cell phenotype and inhibits apoptosis.

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SRP6495 IGF 1R/CD221 human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE) Human
SRP0350 IGF-1R active human recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE) Human
SRP3062 IGF-Binding Protein 1 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested Human
SRP3063 IGF-Binding Protein 2 human recombinant, expressed in (BTI-Tn-5B1-4) High-5 Insect Cells, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested Human
SRP3064 IGF-Binding Protein 4 human recombinant, expressed in (BTI-Tn-5B1-4) High-5 Insect Cells, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested Human
SRP3065 IGF-Binding Protein 6 human recombinant, expressed in (BTI-Tn-5B1-4) High-5 Insect Cells, ≥95% (SDS-PAGE), ≥95% (HPLC), cell culture tested Human
SRP3066 IGF-Binding Protein 7 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC) Human
SRP3067 IGF-Binding Protein-3 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested Human
SRP3068 IGF-Binding Protein-5 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested Human
SRP4121 IGF-I from rat recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC) rat
SRP3069 IGF-I human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested Human
SRP3265 IGF-II human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC) Human
SRP3070 IGF-II human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested Human
I3657 Insulin-Like Growth Factor Binding Protein-2 from mouse ≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested mouse
I5403 Insulin-Like Growth Factor Binding Protein-2 human recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE) Human
I5278 Insulin-Like Growth Factor Binding Protein-3 human recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE) Human
I4402 Insulin-like Growth Factor Binding Protein-4 human >97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder Human
I3782 Insulin-like Growth Factor Binding Protein-5 from mouse ≥90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder mouse
I8529 Insulin-like Growth Factor Binding Protein-5 human >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder Human
I9029 Insulin-like Growth Factor Binding Protein-6 human >97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder Human
I2656 Insulin-like Growth Factor-I (E3R) human >95% (HPLC), recombinant, expressed in E. coli, lyophilized powder  
I4657 Insulin-like Growth Factor-I Receptor human ≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder Human
I8779 Insulin-like Growth Factor-I from mouse IGF-I, recombinant, expressed in E. coli, lyophilized powder, cell culture tested mouse
I3769 Insulin-like Growth Factor-I human IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture Human
I8904 Insulin-like Growth Factor-II from mouse IGF-II, recombinant, expressed in E. coli, lyophilized powder mouse
I2526 Insulin-like Growth Factor-II human IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture Human
I1146 R3 IGF-1 human recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture Human
H8166 pro Insulin-like Growth Factor-II human recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture Human