Biological Buffers


Synonym: Piperazine-1,4-bis(2-hydroxypropanesulfonic acid) dihydrate, Piperazine-N,N′-bis(2-hydroxypropanesulfonic acid)

POPSO has been used to store DNA samples to avoid cross reactivity of amine groups when using an aminoallyl-labeling procedure1.
Useful pH Range 7.2 - 8.5
Working concentration range 10mM3 


        Comparison of products by grade or quality level
Name CAS Molecular Formula Mol Wt Reagent Grades Life Science Grades PharmaGrade  Solutions
POPSO hydrate 68189-43-5 C10H22N2O8S2 · xH2O 362.42 (anhydrous basis) P3405      
POPSO sesquisodium salt 108321-08-0 C20H41N4Na3O16S4 790.79        


Interaction Comments

No interactions found


Literature References

  1. Microarray-based DNA methylation profiling: technology and applications. A Schumacher et. al. Nucleic Acids Research, 34(2), 528-542 (2006)
  2. Ferreira CM, Pinto IS, Soares, EV, Soares HM. 2015 Royal Society of Chemistry 30989- 31003
  3. Kebede N, Francis PS, Barbante GJ, Hogan CF, Electrogenerated chemiluminescence of tris (2,2’ biopyridine) ruthenium (II) using common biological buffers as co-reactant, pH buffer and supporting electrolyte, Royal Society of Chemistry 2015(140) pp7142-7145