esiRNA Guarantee

MISSION® esiRNA will reduce target mRNA levels by 70%, in cultured cells, when transfected at a concentration of ≥30 nM. If the esiRNA does not knock down the target gene by 70%, we will provide an additional esiRNA for that gene, free of charge. If there are no more esiRNA for that gene, we will refund the purchase price.

Receipt of appropriate supporting data for transfection efficiency is required for the guarantee. Appropriate supporting data for transfection efficiency would include qPCR data comparing target mRNA levels of a validated MISSION esiRNA, transfected at ≥30 nM, to an appropriate negative control (such as mock transfection, RLUC, FLUC, or eGFP esiRNA), demonstrating knockdown of the target mRNA of 70%.

Due to the variability of antibodies and protein half-lives, we are unable to accept data from protein-based detection methods.