siRNA

Custom siRNA Libraries & Panels

MISSION® Custom siRNA Libraries & Panels are the most compelling collections for high-throughput screening of therapeutic-value target genes. The flexible format facilitates research for scientists who are interested in specific classes of genes as well as those who need to generate information across the entire druggable genome.


 Product Benefits

  • Duplexes designed using the Rosetta Algorithm, one of the most powerful tools for high target specificity and efficient gene knockdown
  • Up to 3 duplexes available per gene, thereby allowing for optional pooling
  • Amounts of material provided allow for multiple screenings and hit follow-up
  • Gene targets picked in collaboration with major pharmaceutical company

 Product Features

  • 21mer siRNA duplexes with dTdT overhangs
  • Duplex amounts provided vary (see list below)
  • 1 to 3 duplexes available per gene
  • Duplexes formatted in multiple 96-well plates
    o   80 duplexes per plate
    o   First/last columns empty
    o   Dry
  • Items provided electronically, include:
    o   Plate maps
    o   Target gene list
    o   Sequence information
  • Controls may be available (inquire)

 Available Libraries & Panels

Select the library or panel of interest and then use the button above to complete the quote request form. To learn if controls are included as well as the list of genes in the library or panel of interest, please send an email to sirnarequest@sial.com.

 

Library /
Panel No.
Product Name Number of Targets Duplex Amount
Human
1 MISSION® siRNA Human Druggable Genome Library 6655 1 nmol
2 MISSION® Human Gene Family Panels Ligase Panel 949 1 nmol
3 MISSION® siRNA Human Gene Family Panels Human Growth Factors/Receptors Panel 375 1 nmol
4 MISSION® siRNA Human Gene Family Panels Cell Adhesion and Cytoskeleton Panel 496 1 nmol
5 MISSION® siRNA Human Gene Family Panels Ion Channel and Transporters Panel 639 1 nmol
6 MISSION® siRNA Human Gene Family Panels Assorted Function Panel 228 1 nmol
7 MISSION® siRNA Human Gene Family Panels GPCR Panel 304 1 nmol
8 MISSION® siRNA Human Gene Family Panels Hydrolase Panel 204 1 nmol
9 MISSION® siRNA Human Gene Family Panels Metabolism and Cell Traffic Panel 217 1 nmol
10 MISSION® Human Nucleic Acid Binding Panel 310 1 nmol
11 MISSION® siRNA Human Gene Family Panels Oxidoreductase Panel 338 1 nmol
12 Human Gene Family Panels Protease Panel 379 1 nmol
13 MISSION® siRNA Human Gene Family Panels Cell Regulation Panel 227 1 nmol
14 MISSION® siRNA Human Gene Family Panels Transfer and Carrier Proteins Panel 71 1 nmol
15 MISSION® siRNA Human Gene Family Panels Transferase Panel 184 1 nmol
16 MISSION® siRNA Human Gene Family Set Kinase Panel 719 0.25 nmol
17 MISSION® siRNA Human Phosphatase Panel 303 0.25 nmol
Mouse
18 MISSION® siRNA Mouse Kinase Panel 623 0.5 nmol
Rat      
19 MISSION® siRNA Rat Druggable Genome Library 6016 1 nmol
20 MISSION® siRNA Rat Gene Family Panels Ligase Panel 816 1 nmol
21 MISSION® siRNA Rat Gene Family Panels Kinase Panel 669 1 nmol
22 MISSION® siRNA Rat Gene Family Panels Phosphatase Panel 266 1 nmol
23 MISSION® siRNA Rat Gene Family Panels Growth Factors/Receptors Panel 342 1 nmol
24 MISSION® siRNA Rat Gene Family Panels Cell Adhesion and Cytoskeleton Panel 433 1 nmol
25 MISSION® siRNA Rat Gene Family Panels Ion Channel and Transporters Panel 594 1 nmol
26 MISSION® siRNA Rat Gene Family Panels Assorted Function Panel 210 1 nmol
27 MISSION® siRNA Rat Gene Family Panels GPCR Panel 275 1 nmol
28 MISSION® siRNA Rat Gene Family Panels Hydrolase Panel 188 1 nmol
29 MISSION® siRNA Rat Gene Family Panels Metabolism and Cell Traffic Panel 201 1 nmol
30 MISSION® siRNA Rat Gene Family Panels Nucleic Acid Binding Panel 287 1 nmol
31 MISSION® siRNA Rat Gene Family Panels Oxidoreductase Panel 302 1 nmol
32 MISSION® siRNA Rat Gene Family Panels Protease Panel 341 1 nmol
33 MISSION® siRNA Rat Gene Family Panels Cell Surface and Nuclear Receptors Panel 647 1 nmol
34 MISSION® siRNA Rat Gene Family Panels Cell Regulation Panel 214 1 nmol
35 MISSION® siRNA Rat Gene Family Panels Transfer and Carrier Proteins Panel 66 1 nmol
36 MISSION® siRNA Rat Gene Family Panels Transferase Panel 174 1 nmol


 Select Citations

  • Gilot D, Le Meur N, Giudicelli F, Le Vee M, Lagadic-Gossmann D, Theret N, & Fardel O (2011). RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity. PLoS ONE, 6(3):e18261, 1-10.
  • Meng W, Mushika Y, Ichii T, & Takeichi M (2008). Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Cell, 135, 948-59.
  • Matsubara T, Kida K, Yamaguchi A, Hata K, Ichida F, Meguro H, Aburatani H, Nishimura R, & Yoneda T (2008). BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation. J Biol Chem, 283, 29119-25.
  • Zhou H, Xu M, Huang Q, Gates AT, Zhang XD, Castle JC, Stec E, Ferre M, Strulovici B, Hazuda DJ, & Espeseth AS (2008). Genome-scale RNAi screen for host factors required for HIV replication. Cell Host Microbe, 4, 495-504.
  • Espeseth AS, Huang Q, Gates A, Xu M, Yu Y, Simon AJ, Shi XP, Zhang X, Hodor P, Stone DJ, Burchard J, Cavet G, Bartz S, Linsley P, Ray WJ, & Hazuda D (2006). Genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels. Mol Cell Neurosci, 33, 227–35.
  • Bartz SR, Zhang Z, Burchard J, Imakura M, Martin M, Palmieri A, Needham R, Guo J, Gordon M, Chung N, Warrener P, Jackson AL, Carleton M, Oatley M, Locco L, Santini F, Smith T, Kunapuli P, Ferrer M, Strulovici B, Friend SH, & Linsley PS (2006). Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions. Mol Cell Biol,  26, 9377–86.
  • Majercak J, Ray WJ, Espeseth A, Simon A, Shi XP, Wolffe C, Getty K, Marine S, Stec E, Ferrer M, Strulovici B, Bartz S, Gates A, Xu M, Huang Q, Ma L, Shughrue P, Burchard J, Colussi D, Pietrak B, Kahana J, Beher D, Rosahl T, Shearman M, Hazuda D, Sachs AB, Koblan KS, Seabrook GR, & Stone DJ (2006). LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer’s disease. Proc Natl Acad Sci, 103, 17967–72.

MISSION is a trademark of Merck KGaA, Darmstadt, Germany and/or its affiliates. Label License.