BioFiles Volume 4, Number 8 — Metabolomics

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Amino Acid Metabolites in Natural Product Biosynthesis

The biosynthesis of nonribosomal peptide natural products can also utilize amino acids which differ from the proteinogenic amino acids required for the ribosomal machinery. Several hundred other building blocks, in addition to the the 20 standard amino acids found in proteins, can be incorporated into the final products of non-ribosomal peptide synthesis. Beside the pathways dependent on nonribosomal peptide synthetases (NRPS), complex natural products are also formed by NRPS-independent pathways. Non-proteinogenic amino acids like 3-amino-5-hydroxy-benzoic acid for the biosynthesis of ansamycin or 3,5-dihydroxyphenylglycine for vancomycin and teicoplanin biosynthesis offer interesting building blocks for a diversity of natural products.


Description Product No.
l-2-Aminoadipic acid, ≥98% (TLC) A7275
7-Aminocephalosporanic acid, 98% 191140
3-Amino-5-hydroxybenzoic acid hydrochloride, ≥97.0% (HPLC) 05881
N-(p-Coumaroyl)-lhomoserine lactone, ≥94% (HPLC) 07077
L-2,3-Diaminopropionic acid hydrochloride, ≥97.0% 33270
(S)-3,5-Dihydroxyphenylglycine hydrate, ≥98% (HPLC) D3689
4-Hydroxy-lphenylglycine, puriss., ≥99.0% (NT) 56160
4-Hydroxyphenylpyruvic acid, 98% 114286
Indole-3-pyruvic acid I7017
D-Penicillamine, 98-101% P4875
D-Pipecolinic acid, 99% 268062
Porphobilinogen P1134
2,3-Pyridinedicarboxylic acid, 99% P63204
Tryptamine, ≥99% T2891
Tyramine hydrochloride, ≥98% T2879

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