BioFiles Volume 5, Number 7 — Lipid Metabolism

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The development of cognitive and neurodegenerative disorders, cardiovascular diseases, metabolic disorders, bone diseases, certain forms of cancer, and autoimmune diseases with increasing age has been associated with the stability of the cell and biochemical reactions within it. Like DNA and proteins, lipids are sensitive to reactive oxygen species that produce oxidative stress. Endogenous aldehydes, such as malonic dialdehyde and methylglyoxal, are the major initiators of metabolic disorders. Age-related diseases develop when cells cannot control aldehyde formation or abolish the negative methylglyoxal effect on their metabolism. Toxic aldehydes cause cumulative damage over a lifetime if not counteracted by the cell′s ability to avoid the formation of endogenous aldehydes or to neutralize their negative effects without damaging vital cellular components. The aging process and the individual′s life span is influenced by the balance of the two opposing processes of antiaging effects and the aging effects of toxic aldehydes.

Cholesterol levels in human serum above 6.5 mmol/L are known to be associated with a higher risk of developing Alzheimer′s disease, while a reduction of cholesterol in the serum in midlife lowers the risk of dementia. Bile acids act as regulators of aging that benefit health and longevity and modulate housekeeping longevity assurance pathways. It is likely that the mechanisms for the positive effects of bile acids are evolutionarily conserved. The time-dependent accumulation of age pigments like lipofuscin occurs in all cells, but it is more prominent in cells which are not active in cell division. These age pigments appear together with lipid droplets in the cytoplasm.

Description Product No.
Cholesterol C8667-500MG
Malondialdehyde tetrabutylammonium salt 63287-1G-F
Methylglyoxal solution M0252-25ML
(+)-α-Tocopherol, activity: =1000 IU/g T1539-25MG
Xanthophyll X6250-1MG

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