Histone Deacetylase Inhibitors

Histone deacetylases (HDACs) are enzymes that remove acetyl groups from lysines of histones and a number of other regulatory and structural proteins. They play critical roles in chromatin remodeling and are involved in transcription regulation, cell-cycle progression, cell survival and differentiation. So far, 18 HDACs have been identified and divided into 3 distinct enzyme classes.
Class I and II HDACs are zinc dependent. Class I, homologous to yeast Rpd3, includes HDAC1, 2, 3, and 8. Class II (HDAC4, 5, 6, 7, 9, 10) resembles yeast Hda1. Class I and II HDACs are associated with malignant transformations and are targets for cancer drugs. Inhibitors of Class I and II HDACs are largely classified into four groups on the basis of their chemical structures.