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Noni (Morinda citrifolia)

Noni (Morinda citrifolia) Image
Synonyms / Common Names / Related Terms
Al, alizarin, alkaloids, americanin A, amino acids, anthraquinone, anthraquinone glycoside, asperuloside, asperulosidic acid, atchy (Hindi), ß-sitosterol, borreriagenin, cada pilva (Malay), caproic acid, caprylic acid, carotene, citrifolinin B epimer a, citrifolinin B epimer b, citrifolinoside, cytidine, deacetylasperuloside, dehydromethoxygaertneroside, d-glucose, dilo'k (Pijin), d-mannitol, epi-dihydrocornin, flavone glycosides, Indian mulberry, iridoid glycoside, kura (Fijian), kuti, ladda (Chamorro), L-asperuloside, linoleic acid, maddichettoo (Telugu), manja-pavattay, methyl alpha-d-fructofuranoside, methyl beta-d-fructofuranoside, molagha, Morinda citrifolia, morindacin, morindone, murier d'Inde, najalanun, nakura, narcissoside, nen (Chamorro), nicotifloroside, nolom, nono (Cook Islands Maori), nonu (Tongan, Wallisian, Futunian, Niuean, Tokelauan, Tuvaluan), nonu togi (Samoan), noona (Tamil), nordamnacanthal, nowoi (Bislama), octanoic acid, potassium, riro (Tok Pisin), proxeronine, Rubiaceae (family), rubiadin, rubiadin-1-methyl ether, rutin, scopoletin, te non (Gilbertese), terpenoids, TNJ, ursolic acid, vitamin A, vitamin C, yelotri.

Combination product examples: Tahitian Noni® juice (noni fruit juice from juice puree, grape juice concentrate, blueberry juice concentrate, natural flavors).

Mechanism of Action


  • Constituents: Various components have been identified in the noni plant, such as scopoletin, octanoic acid, potassium, vitamin C, terpenoids, alkaloids, anthraquinones (such as nordamnacanthal, morindone, rubiadin, rubiadin-1-methyl ether, anthraquinone glycoside), ß-sitosterol, carotene, vitamin A, flavone glycosides, linoleic acid, alizarin, amino acids, L-asperuloside, caproic acid, caprylic acid, ursolic acid, rutin, and a putative proxeronine.49,50,51,8,52,53,54,55,56,57,58,59,20,60 Several flavonol glycosides have also been identified, including an iridoid glycoside from the noni leaves, a trisaccharide fatty acid ester, rutin, two novel glycosides, citrifolinoside, and an asperulosidic acid from the fruit.61,45,34,62,63,33,36 Six anthraquinones, including 5,15-O-dimethylmorindol, and three iridoids, including morindacin, have also been isolated from Morinda citrifolia fruits.1
  • The methanol extract of Morinda citrifolia fruits contains 6alpha-hydroxyadoxoside, 6beta,7beta-epoxy-8-epi-splendoside, americanin A, narcissoside, asperuloside, asperulosidic acid, borreriagenin, citrifolinin B epimers a and b, cytidine, deacetylasperuloside, dehydromethoxygaertneroside, epi-dihydrocornin, d-glucose, d-mannitol, methyl alpha-d-fructofuranoside, methyl beta-d-fructofuranoside, nicotifloroside, 2-methoxy-1,3,6-trihydroxyanthraquinone, and beta-sitosterol 3-O-beta-d-glucopyranoside.64,2
  • Analgesic effects: A Morinda citrifolia extract showed a significant, dose-related, central analgesic effect in mice, which was 75% as strong as morphine, yet non-addictive and side effect-free.12 In a similar study, Tahitian Noni® juice (TNJ) had a dose-dependent analgesic effect on antimony potassium tartrate-induced pain in mice and rats.11 In an acetic acid-induced writhing test in mice, the alcoholic extract of Morinda citrifolia fruits had a dose-dependent inhibitory effect, starting at 4g/kg, which was similar to that produced by morphine in a dose of 1.5mg/kg.65 The antinociceptive effect in the writhing test was statistically significant (p<0.001) for 15 minutes until five hours after administration. In a Phase I trial in cancer patients, there was a statistically significant (t(35)=-2.84, p=0.006) decrease in pain interference after a week of noni in doses of 2, 4, 6, 8, or 10g.3
  • Anthelmintic effects: In an in vitro study, a noni leaf ethanol extract induced paralysis and death of the human parasitic nematode worm Ascaris lumbricoides within 24 hours.13
  • Antiangiogenic effects: Noni at concentrations of >5% by volume was highly effective in inhibiting the initiation of new vessel sprouts from placental vein explants, and 10% noni juice in media was an effective inhibitor of capillary initiation in explants from human breast tumors.14
  • Cardiovascular effects: The oxidative modification of low-density lipoprotein (LDL) plays an important role in the genesis of arteriosclerosis. A study by Kamiya et al. focused on the effects of the fruits of Morinda citrifolia on preventing arteriosclerosis.25 The MeOH extract and CHCl3-, EtOAc-, n-BuOH-, and H2O-soluble phases derived from the fruits of Morinda citrifolia were evaluated for their inhibitory activity on copper-induced LDL oxidation by the thiobarbituric acid-reactive substances (TBARS) method. The MeOH extract and EtOAc-soluble phase showed 88% and 96% inhibition respectively. Six lignans were isolated by repeated column chromatography from the EtOAc-soluble phase: 3,3'-bisdemethylpinoresinol, americanol A, americanin A, americanoic acid A, morindolin and isoprincepin. These compounds inhibited copper-induced LDL oxidation in a dose-dependent manner. 1, 2, 5, and 6 exhibited remarkably strong activities, which were the same or better than that of the known antioxidant 2,6-di-tert-butyl-p-cresol. The IC50 values for 1, 2, 5, and 6 were 1.057, 2.447, 2.020 and 1.362mcM, respectively. The activity of these compounds is mainly due to their number of phenolic hydroxyl groups. When noni's potential to inhibit oxidation of low-density lipoprotein (LDL) in vitro and to modulate LDL receptor (LDLr) activity in cultured HepG2 cells was tested, LDLr was significantly up-regulated (p<0.05) by noni (49%).66 In a similar study, noni-caused inhibition of 14C incorporation in HepG2 cells, (77% compared to control).67 However, this decrease in incorporation cannot be accounted for by the inhibition of cholesterol synthesis alone. The proportion of cholesterol in the sample decreased from 38% in the control to 28% in the presence of noni: evidence that synthesis of cholesterol was inhibited. After taking into account the relative differences in total 14C incorporation, noni caused a 26% inhibition in cholesterol synthesis, compared to 55% inhibition by the positive control lovastatin hydroxy acid. It could not be established what caused the overall decrease in 14C incorporation in the presence of noni, but its mode of action would appear to be different to that of lovastatin hydroxy acid.
  • In animal studies, the total extract of the noni roots and various noni root extracts have shown a hypotensive effect, although the mechanism for this effect is not clear.5,6,7,8,9,10
  • Antibacterial effects: Specific compounds from various parts of the noni plant have been effective in laboratory studies as antibacterial agents, supporting the Polynesian traditional medicinal use for infectious diseases.18,19 In an in vitro study, extracts from the ripe noni fruit, including L-asperuloside and alizarin, exhibited moderate antibacterial properties against Pseudomonas aeruginosa, Micrococcus pyrogenes, Escherichia coli, Pseudomonas aeruginosa, Proteus morgaii, Staphylococcus aureus, Bacillis subtilis, Salmonella, and Shigela.16Some anthraquinone compounds from noni roots were also effective against strains of Pseudomonas aeruginosa, Proteus morgaii, Staphylococcus aureus, Bacillis subtilis, Escherichia coli, Salmonella, and Shigela.15 Specifically, the compound scopoletin from noni inhibits the activity of Escherichia coli and H. pylori.17 Also, a concentrated noni leaf extract killed 89% of Mycobacterium tuberculosis in a test tube, compared to rifampin, a leading anti-tuberculosis drug, which has an inhibition rate of 97% at the same concentration.20
  • Anti-inflammatory effects: In various animal and in vitro studies, noni shows promise as an anti-inflammatory agent. In an in vitro studies, Tahitian Noni® Juice had comparable selectivity of COX-2 inhibition as celecoxib (0.34)21 and Morinda citrifolia fruit powder exhibited inhibition of COX-1 with the IC50 of 163mc/mL, compared to aspirin (IC50=241mc/mL) and indomethacin (IC50=1.2mc/mL)22. In animal studies, Tahitian Noni® juice decreased inflammatory foci in an acute liver injury rat model23, and orally and intraperitoneally administered noni fruit juice extract reduced inflammation in bradykinin-induced inflammation and carrageenan-induced paw edema24.
  • Antioxidant effects: In vitro Tahitian Noni® juice (TNJ) showed a dose-dependent inhibition of both lipid peroxides and superoxide anion radicals comparable to grape seed powder.45,46,47 This result was supported by a rat liver injury model, where 10% TNJ in the drinking water reduced lipid peroxides and superoxide anion radicals after liver injury induction.23 In terms of both 1,1-diphenyl-2-picrylhydrazyl (DPPH) and peroxynitrite (ONOO(-)) bioassays, the noni neolignan americanin A was found to be a potent antioxidant in these assays.64 Various treatments of noni juice may affect its antioxidant properties. For example, Yang et al. report the total antioxidant capacity (TAC) in fresh noni juice to be equivalent to 127mg ascorbic acid per 100mL in a scavenger assay of 1,1-diphenyl-2-picrylhydrazyl (DPPH).48 After two months traditional fermentation, TAC decreased by 70%. Storage of fresh noni juice at 24ºC for two months decreased TAC by 80%, while storage at -18ºC exhibited no significant change in TAC. Hot air and freeze-dried noni powders exhibited reduction in TAC by 45% and 20%, respectively. The pasteurization of noni juice seems to have no effect on its chemistry and performance in oxygen radical absorbance capacity (ORAC) assays, but enzyme treatment seems to have a negative effect on antioxidant capacity.40
  • Antitumor effects: Various extracts and constituents from all parts of the noni plant have been tested for their effect on animal cancer models and cell lines. In several studies, the noni extract suppressed tumor growth through activation of the host immune system26,27,28,29,30, which is supported by another noni study showing general immunostimulation effects11. Noni has also shown general cytotoxicity effects31, which may be dose-dependent11. However, these effects are not universal across all cancer lines.31 Noni extracts have exhibited specific inhibitory effects on Ras oncogene function32, cell transformation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) or epidermal growth factor (EGF)33,34 , the tumor-promoting effect of tumor necrosis factor-a (TNF-a)35, and activator protein-1 transactivation36. When administered before the induction of a cancer, noni extract has shown preventative effects.23,37,38,39 Specifically, the anthraquinone 2-methoxy-1,3,6-trihydroxyanthraquinone may be a potent quinine reducatase inducer that is nearly 40 times more potent than the positive control l-sulforaphane.2 On a side note, the pasteurization of noni juice seems to have no effect on its chemistry and performance in NF-kappa B activity.40
  • Antiviral effects: One specific compound isolated from noni roots, 1-methoxy2-formyl-3-hydroxy anthraquinone, suppressed cytopathic effect of HIV-infected MT-4 cells in vitro, without inhibiting cell growth.41 However, the aqueous and dichloromethane extract of noni fruits showed practically no activity against HIV-1 in vitro.42
  • Gastrointestinal effects: Pu et al. studied the effects of Morinda citrifolia juice on gastric emptying, gastrointestinal transit, and plasma level of cholecystokinin in rats.4 Male rats were given noni by gavage at levels of 0.25, 1, or 4mL/kg once per day for one or seven days. The rats in the control group were given water, while the rats in the experimental group were fasted overnight before measurement of gastrointestinal motility. Gastrointestinal motility was assessed in rats 15 minutes after intragastric instillation of a test meal containing charcoal (10%) and Na251CrO4 (0.5mcCi/mL) as a marker. Gastric emptying was determined by measuring the amount of radio-labeled chromium contained in the small intestine as a percentage of the initial amount received. Then, gastrointestinal transit was evaluated by calculating the geometric center of distribution of the radio-labeled marker. Finally, blood samples were collected for measurement of cholecystokinin by radioimmunoassay. The administration of noni at 0.25mL/kg, but not at 1mL/kg and 4mL/kg, for one day significantly inhibited gastric emptying. In contrast, gastric emptying was significantly inhibited by oral administration of noni (0.25, 1, or 4mL/kg) for seven days. Intraperitoneal injection of lorglumide (5 or 10mg/kg), a selective cholecystokinin 1 receptor antagonist, effectively attenuated the noni-induced inhibition of gastric emptying. Intestinal transit and body weight, food intake, water intake, urine volume, and feces weight were not altered by the administration of noni acutely or chronically, but the administration of oral noni (1mL/kg) for seven days increased the level of plasma cholecystokinin in male rats. These results suggest that oral noni inhibits gastric emptying in male rats via a mechanism involving stimulation of cholecystokinin secretion and cholecystokinin 1 receptor activation.
  • Immune system effects: The thymus wet weight in animals treated with Tahitian Noni® juice (TNJ) was about 1.7 times that of control animals after seven days administration of 10% TNJ in drinking water.11 This increase in weight may indicate that TNJ enhances immune function by stimulating thymus growth, and thus affecting anti-aging and anticancer activities.
  • Metabolic effects: Noni fruit contains a natural precursor for xeronine, called proxeronine, which is hypothetically converted in the body to the alkaloid xeronine. It has been hypothesized that xeronine is able to modify the molecular structure of proteins and is a critical normal metabolic co-regulator.43,44


  • The pharmacokinetics of noni was studied in female Sprague Dawley rats after oral administration at a dose of 1mL noni puree per 100g body weight with scopoletin as a marker.11 The plasma concentration of scopoletin reached a peak two hours after oral administration. The peak level decreased to 50% in four hours. Only 12% and 2%, respectively, was left in the plasma at 12 and 24 hours. Absorption was rapid, with 50% peak concentration reached in only 30 minutes. The concentration of scopoletin in various organs indicates that it is absorbed into different tissues approximately one hour after administration. The peak concentration in different tissues occurred after about three hours, with a rapid decline. The scopoletin level in breast tissue was higher relative to other extra-gastrointestinal tract tissue. This is not a definite description of noni pharmacokinetics as noni is an extract composed of numerous components. The measurement of scopoletin as a marker of the noni compound cannot be assumed to represent the rest, or even the majority of noni compounds.


  1. Kamiya, K., Tanaka, Y., Endang, H., Umar, M., and Satake, T. New anthraquinone and iridoid from the fruits of Morinda citrifolia. Chem Pharm Bull (Tokyo) 2005;53(12):1597-1599. 16327199
  2. Pawlus, A. D., Su, B. N., Keller, W. J., and Kinghorn, A. D. An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolia (noni). J Nat Prod 2005;68(12):1720-1722. 16378361
  3. Issell, B. F., Gotay, C., Pagano, I., and Franke, A. Quality of life measures in a phase I trial of noni  2005;
  4. Pu, H. F., Huang, W. J., Tseng, W. M., Wang, S. W., Liu, Y. W., Doong, M. L., and Wang, P. S. Effects of juice from Morinda citrifolia (Noni) on gastric emptying in male rats. Chin J Physiol 12-31-2004;47(4):169-174. 15803749
  5. DANG, VAN HO. [A basic treatment for arterial hypertension with extracts of the roots of Morinda citrifilia (Cay-Nhau).]. Presse Med 7-3-1954;62(48):1020-1021. 13194596
  6. DANG, VAN HO. [Treatment and prevention of hypertension and its cerebral complications by total root extracts of Morinda citrifolia.]. Presse Med 11-2-1955;63(72):1478. 13280670
  7. LA BARRE, J., HANS, M., and HANS, M. J. [Apropos of the hypotensive, diuretic and tranquilizing properties of purified extracts of Morinda.]. Bull Acad R Med Belg  1961;1:567-581. 13757907
  8. Moorthy, N. K. and Reddy, G. S. Preliminary phytochemical and pharmacological study of Morinda citrifoliaL. Antiseptic 1970;97:167-171.
  9. YOUNGKEN, H. W., Sr. A study of the root of Morinda citrifolia Linne. I. J Am Pharm Assoc Am Pharm Assoc (Baltim) 1958;47(3, Part 1):162-165. 13525210
  10. YOUNGKEN, H. W., Sr., JENKINS, H. J., and BUTLER, C. L. Studies on Morinda citrifolia L. II. J Am Pharm Assoc Am Pharm Assoc  1960;49:271-273. 13855457
  11. Wang, M. Y., West, B. J., Jensen, C. J., Nowicki, D., Su, C., Palu, A. K., and Anderson, G. Morinda citrifolia (Noni): a literature review and recent advances in Noni research. Acta Pharmacol Sin  2002;23(12):1127-1141. 12466051
  12. Younos, C., Rolland, A., Fleurentin, J., Lanhers, M. C., Misslin, R., and Mortier, F. Analgesic and behavioural effects of Morinda citrifolia. Planta Med 1990;56(5):430-434. 1981810
  13. Raj, R. K. Screening of indigenous plants for anthelmintic action against human Ascaris lumbricoides: Part--II. Indian J Physiol Pharmacol 1975;19(1):UNKNOWN. 1158424
  14. Hornick, C. A., Myers, A., Sadowska-Krowicka, H., Anthony, C. T., and Woltering, E. A. Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia (noni). Angiogenesis  2003;6(2):143-149. 14739620
  15. ATKINSON, N. Antibacterial substances from flowering plants. 3. Antibacterial activity of dried Australian plants by a rapid direct plate test. Aust J Exp Biol Med Sci 1956;34(1):17-26. 13328723
  16. Bushnell, O. A., Fukuda, M., and Makinodian, T. The antibacterial properties of some plants found in Hawaii. Pac Sci 1950;4:167-183.
  17. Duncan, S. H., Flint, H. J., and Stewart, C. S. Inhibitory activity of gut bacteria against Escherichia coli 0157 mediated by dietary plant metabolites. FEMS Microbiol Lett 1998;164:283-285.
  18. Locher, C. P., Burch, M. T., Mower, H. F., Berestecky, J., Davis, H., Van Poel, B., Lasure, A., Vanden Berghe, D. A., and Vlietinck, A. J. Anti-microbial activity and anti-complement activity of extracts obtained from selected Hawaiian medicinal plants. J Ethnopharmacol 11-17-1995;49(1):23-32. 8786654
  19. Leach, A. J., Leach, D. N., and Leach, G. J. Antibacterial activity of some medicinal plants of Papua New Guinea. Sci New Guinea 1988;14:1-7.
  20. Saludes, J. P., Garson, M. J., Franzblau, S. G., and Aguinaldo, A. M. Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae). Phytother Res 2002;16(7):683-685. 12410555
  21. Su, C., Wang, M. Y., Nowicki, D., Jensen, J., and Anderson, G. Selective COX-2 inhibition of Morinda citrifolia(Noni)in vitro  2001;7th Ann Conf
  22. Li, R. W., Myers, S. P., Leach, D. N., Lin, G. D., and Leach, G. A cross-cultural study: anti-inflammatory activity of Australian and Chinese plants. J Ethnopharmacol 2003;85(1):25-32. 12576199
  23. Wang, M. Y., Su, C., Nowicki, D., Jensen, J., and Anderson, G. Morinda citrifoliaand cancer prevention. J Nutrition 2001;131(11S):3151S.
  24. McKoy, M. L., Thomas, E. A., and Simon, O. R. Preliminary investigation of the anti-inflammatory properties of an aqueous extract from Morinda citrifolia (noni). Proc West Pharmacol Soc  2002;45:76-78. 12434536
  25. Kamiya, K., Tanaka, Y., Endang, H., Umar, M., and Satake, T. Chemical constituents of Morinda citrifolia fruits inhibit copper-induced low-density lipoprotein oxidation. J Agric Food Chem  9-22-2004;52(19):5843-5848. 15366830
  26. Hirazumi, A., Furusawa, E., Chou, S. C., and Hokama, Y. Anticancer activity of Morinda citrifolia (noni) on intraperitoneally implanted Lewis lung carcinoma in syngeneic mice. Proc West Pharmacol Soc  1994;37:145-146. 7984648
  27. Hirazumi, A., Furusawa, E., Chou, S. C., and Hokama, Y. Immunomodulation contributes to the anticancer activity of morinda citrifolia (noni) fruit juice. Proc West Pharmacol Soc  1996;39:7-9. 8895953
  28. Hirazumi, A. and Furusawa, E. An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumour activity. Phytother Res 1999;13(5):380-387. 10441776
  29. Furusawa, E., Hirazumi, A., Story, S., and Jensen, J. Antitumour potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumour in mice. Phytother Res 2003;17(10):1158-1164. 14669249
  30. Hokama, Y. The effect of Noni fruit extract (Morinda citrifolia, Indian mulberry) on thymocytes of BALB/c mouse. FASEB J 1993;7:A866.
  31. Arpornsuwan, T. and Punjanon, T. Tumor cell-selective antiproliferative effect of the extract from Morinda citrifolia fruits. Phytother Res 2006;20(6):515-517. 16619339
  32. Hiramatsu, T., Imoto, M., Koyano, T., and Umezawa, K. Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia. Cancer Lett  9-30-1993;73(2-3):161-166. 7693328
  33. Liu, G., Bode, A., Ma, W. Y., Sang, S., Ho, C. T., and Dong, Z. Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line. Cancer Res 8-1-2001;61(15):5749-5756. 11479211
  34. Sang, S., He, K., Liu, G., Zhu, N., Cheng, X., Wang, M., Zheng, Q., Dong, Z., Ghai, G., Rosen, R. T., and Ho, C. T. A new unusual iridoid with inhibition of activator protein-1 (AP-1) from the leaves of Morinda citrifolia L. Org Lett 5-3-2001;3(9):1307-1309. 11348221
  35. Asahina, A. Y., Ebesu, J. S. M., Ichinotsubo, D., Tongson, J., and Hokama, Y. Effect of okadaic acid (OA) and Noni fruit extraction in the synthesis of tumour necrosis factor-a (TNF-a) by peripheral blood mononuclear (PBN) cells in vitro  1994;197-205.
  36. Sang, S., Liu, G., He, K., Zhu, N., Dong, Z., Zheng, Q., Rosen, R. T., and Ho, C. T. New unusual iridoids from the leaves of noni (Morinda citrifolia L.) show inhibitory effect on ultraviolet B-induced transcriptional activator protein-1 (AP-1) activity. Bioorg Med Chem  6-12-2003;11(12):2499-2502. 12757717
  37. Wang, M. Y., Anderson, G., and Nowicki, D. Preventive effect of Morinda citrifolia(Noni) at the initiation stage of mammary breast cancer induced by 7,12-dimethylbenz(a)-anthracen (DMBA) in female Sprague-Dawley rats  2002;
  38. Wang, M. Y., Nowicki, D., and Anderson, G. Protective effect of Morinda citrifolia on hepatic injury induced by a liver carcinogen  2002;43:477.
  39. Hiwasa, T., Arase, Y., Chen, Z., Kita, K., Umezawa, K., Ito, H., and Suzuki, N. Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. FEBS Lett 2-12-1999;444(2-3):173-176. 10050753
  40. Banbury, L. and Brushett, D. Report on Investigation of Noni Juice. Unpublished manuscript 2004;
  41. Umezawa, K. Isolation of 1-methoxy-2-foremyl-3-hydroxyanthraquinone from M. citrifolia and neoplasminhibitors containing the same. Japan Kokai Tokyo Koho JP 06 87,736 (94-87,736) 1992;Appl:92-264-311 07.
  42. Locher, C. P., Wtivrouw, M., Bethunne de, M. P., Burch, M. T., Mover, H. F., Davis, H., Lasure, A., Pauwels, R., Clercq de, E., and Vlietnick, A. J. Antiviral activity of Haiwaiian medicinal plants against human immunodeficiency Virus Type-1 (HIV-1). Phytomedicine 1996;2(3):259-264.
  43. Heinicke, R. The pharmacologically active ingredient of Noni  1985;
  44. Heinicke, R. The Xeronine system: a new cellular mechanism that explains the health promoting action of NONI and Bromelain  2001;
  45. Wang, M., Kikuzaki, H., Jin, Y., Nakatani, N., Zhu, N., Csiszar, K., Boyd, C., Rosen, R. T., Ghai, G., and Ho, C. T. Novel glycosides from noni (Morinda citrifolia). J Nat Prod 2000;63(8):1182-1183. 10978225
  46. Wang, M. Y. and Su, C. Cancer preventive effect of Morinda citrifolia (Noni). Ann N Y Acad Sci 2001;952:161-168. 11795436
  47. Wang, M. Y., Su, C., Nowicki, D., Jensen, J., and Anderson, G. Protective effect of Morinda citrifoliain carbontetrachloride-induced liver injury model: A light and electron microscopic study  2001;7th Ann Conf
  48. Yang, J., Paulino, R. J., and Janke-Stedronsky, S. Total antioxidant capacity of Noni Products as Affected by Processing and Storage  2004;
  49. Levand, O. and Larson, H. O. Some chemical constituents of Morinda citrifolia. Planta Med 1979;36(2):186-187. 461575
  50. Farine, J. P., Legal, L., Moreteau, B., and Le Quere, J. L. Volatile components of ripe fruits of Morinda citrifoliaand their effects on Drosophila. Phytochemistry 1996;41:433-438.
  51. Peerzada, N., Renaud, S., and Ryan, P. Vitamin C and elemental composition of some bushfruits. J Plant Nutrition 1990;13:787-793.
  52. Daulatabad, C. D., Mulla, G. M., and Mirajikar, A. M. Riconoleic acid in Morinda citrifoliaseed oil. Oil Tech Ass India 1989;21:26-27.
  53. Balakrishna, S., Seshadri, TR., and Venkataramani, B. Special chemical component of commercial woods and related plant materials: Part X-Heartwood of Morinda citrifoliaLinn. J Sci Ind Res 1961;20B:331-333.
  54. Legal, L., David, J. R., and Jallon, J. M. Molecular basis of Morinda citrifolia(L. ): toxicity on Drosophila. J Chem Ecolog 1994;20:1931-1943.
  55. Singh, J. and Tiwari, R. D. Flavone glycosides from the flowers of Morinda citrifolia. J Indian Chem Soc 1976;53:424.
  56. Simonsen, J. L. Note on the constituents of Morinda citrifolia. J Chem Soc 1920;117:561-564.
  57. Siddiqui, B. S., Ismail, F. A., Gulzar, T., and Begum, S. Isolation and structure determination of a benzofuran and a bis-nor-isoprenoid from Aspergillus niger grown on the water soluble fraction of Morinda citrifolia Linn. leaves. Nat Prod Res 2003;17(5):355-360. 14526916
  58. El-Naggar, L. J. and Beal, J. L. Iridoids. A Review. J Nat Prod 1980;43:649-707.
  59. Shotipruk, A., Kiatsongserm, J., Pavasant, P., Goto, M., and Sasaki, M. Pressurized hot water extraction of anthraquinones from the roots of Morinda citrifolia. Biotechnol Prog  2004;20(6):1872-1875. 15575725
  60. Ancolio, C., Azas, N., Mahiou, V., Ollivier, E., Di Giorgio, C., Keita, A., Timon-David, P., and Balansard, G. Antimalarial activity of extracts and alkaloids isolated from six plants used in traditional medicine in Mali and Sao Tome. Phytother Res 2002;16(7):646-649. 12410545
  61. Wang, M., Kikuzaki, H., Csiszar, K., Boyd, C. D., Maunakea, A., Fong, S. F., Ghai, G., Rosen, R. T., Nakatani, N., and Ho, C. T. Novel trisaccharide fatty acid ester identified from the fruits of Morinda citrifolia (Noni). J Agric Food Chem  1999;47(12):4880-4882. 10606546
  62. Sang, S., Cheng, X., Zhu, N., Wang, M., Jhoo, J. W., Stark, R. E., Badmaev, V., Ghai, G., Rosen, R. T., and Ho, C. T. Iridoid glycosides from the leaves of Morinda citrifolia. J Nat Prod 2001;64(6):799-800. 11421748
  63. Sang, S., Cheng, X., Zhu, N., Stark, R. E., Badmaev, V., Ghai, G., Rosen, R. T., and Ho, C. T. Flavonol glycosides and novel iridoid glycoside from the leaves of Morinda citrifolia. J Agric Food Chem  2001;49(9):4478-4481. 11559157
  64. Su, B. N., Pawlus, A. D., Jung, H. A., Keller, W. J., McLaughlin, J. L., and Kinghorn, A. D. Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity. J Nat Prod 2005;68(4):592-595. 15844957
  65. Punjanon, T. and Nandhasri, P. Analgesic effect of the alcoholic extract from the fruits of Morinda citrifolia  2005;4:678.
  66. Salleh, M. N., Runnie, I., Roach, P. D., Mohamed, S., and Abeywardena, M. Y. Inhibition of low-density lipoprotein oxidation and up-regulation of low-density lipoprotein receptor in HepG2 cells by tropical plant extracts. J Agric Food Chem 6-19-2002;50(13):3693-3697. 12059144
  67. Stevenson, L. and Banbury, L. Noni juice and cholesterol synthesis inhibition  2004;

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