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Ginseng (Panax ginseng)

Ginseng (Panax ginseng) Image
Synonyms / Common Names / Related Terms
Ginseng (American ginseng, Asian ginseng, Chinese ginseng, Korean red ginseng, Panax ginseng:Panaxspp., includingP. ginsengC.C. Meyer andP. quinquefoliusL., excludingEleutherococcus senticosus), Acetylenic alcohol, acidic polysaccharides, acupuncture-moxibustion, aglycones, Allheilkraut, American ginseng (AG), American wild ginseng, Araliaceae (family), Asian ginseng, Asiatic ginseng, chikusetsaponin-L8, chikusetsu ginseng, chosen ninjin, CPPQ (coarse polysaccharide from Panax quinquefolius), CVT-E002, dae-jo-hwan (DJW), dwarf ginseng, five-fingers, five-leaf ginseng, G115®, ginsan, ginsenan PA (phagocytosis-activating polysaccharide), ginseng acidic polysaccharide, ginseng radix, ginseng saponins, ginseng tetrapeptide, Ginsengwurzel (German), ginsenoside, ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, and Rg1), ginsenosides compound (shen-fu), GTTC, hakusan, hakushan, higeninjin, hongshen, hua qi shen, hungseng, hungsheng, hunseng, insam, jenseng, jenshen, jinpi, kao-li-seng, Korean ginseng, Korean red ginseng (KRG), Kraftwurzel (German), man root, memory enhancer, minjin, nhan sam, ninjin, ninzin, niuhan, North American ginseng, notoginsenoside, oleanolic acid, Oriental ginseng, otane ninjin, panax de chine, Panax ginseng, Panax ginseng C.A Meyer, Panax notoginseng, Panax, psuedoginseng, Panax quinquefolium (common misspelling), Panax spp., Panax trifolius L., Panax vietamensis (Vietnamese Ginseng), panaxadial, panaxans, panaxatriol, panaxydol, panaxynol, panaxytriol, pannag, polyacetylenic compounds, poly-furanosyl-pyranosyl-saccharides, protopanaxadiol ginsenosides, quinqueginsin, racine de ginseng, red ginseng, renshen, sang, sanchi ginseng, san-pi, schinsent, sei yang sam, seng, shanshen, shen-fu, shenghaishen, shenlu, shen-sai-seng, shenshaishanshen, siyojin, stress-buster, sun ginseng, t'ang-sne, tartar root, tienchi ginseng, to-kai-san, triterpenoids, true ginseng, tyosenninzin, vanillic acid, Vietnamese ginseng, Western ginseng, Western sea ginseng, white ginseng, wild ginseng, woodsgrown (wild-stimulated) ginseng root, xi shen, xi yang shen, yakuyo ninjin, yakuyo ninzin, yang shen, yeh-shan-seng, yuan-seng, yuansheng, zhuzishen.
Siberian ginseng (Eleutherococcus senticosus) synonyms: Acanthopanax senticosus, ci wu jia, ciwujia, devil's bush, devil's shrub, eleuthera, eleuthero, eleuthero ginseng, eleutherococ, eleutherococci radix, Eleutherococcus, Eleutherococcus senticosus, phytoestrogen, shigoka, touch-me-not, wild pepper, wu-jia, wu-jia-pi, ussuri, ussurian thorny pepperbush.
American ginseng (Panax quinquefolius L.) synonyms: American ginseng, amerikan ginseng, amerikanischer Ginseng (German), amerikkalainen ginseng, Anchi ginseng, Aralia quinquefolia Decne. & Planch (botanical synonym), Araliaceae (family), Canadian ginseng, CVT-E 002, five fingers, five leafed ginseng, garantoquen, ginseng, ginseng d'Amérique (French), ginsenosides poly-furanosyl-pyranosyl-saccharides, man-root, man's health, North American ginseng, Occidental ginseng, Ontario ginseng, Panax quincefolium, Panax, quinquefolium, red berry, redberry, sang, shang (TCM), tartar root, western ginseng, wild American ginseng, Wisconsin ginseng, xi yang shen (TCM, Chinese).
Panax ginseng synonyms: Aralia (botanical synonym), Aralia ginseng Mey., Araliaceae (family), Asian ginseng, Asiatic ginseng, Chinese ginseng, G115®, Gincosan, Ginsai®, ginseng asiatique, ginseng radix, ginseng root, ginsengjuuri, guigai, Japanese ginseng, jintsam, Korean ginseng, Korean Panax ginseng, Korean red, Korean red ginseng, kuhuang shenmai injection (KHSM), ninjin, Oriental ginseng, Panax, Panax ginseng, Panax ginseng C. Meyer, Panax schinseng, Panax schinseng Nees, Panax spp., radix ginseng rubra, red ginseng, ren shen (TCM), renshen (TCM), Renxian, sang, schinsent, seng, shen, shengmai, shengmai chenggu capsule, shengmai injection (SI), shengmai san (SMS), shengmai-san, shengmaisan, shengmaiyin, shenmai, shenmai huoxue decoction (SMHXD), shenmai injection (SMI), white ginseng.
Note: This review is focused on Panax ginseng species. Avoid confusing with Eleutherococcus senticosus, which is also known as Siberian ginseng. In Russia, Siberian ginseng was promoted as a cheaper alternative to ginseng as it was believed to have identical benefits. However, it is void of the ginsenosides contained in Panax spp. Other species may be referred to as ginseng as well, but they are from either a different family or genus; examples include Eleutherococcus senticosus (Siberian ginseng), Pseudostellaria heterophylla (prince ginseng), Angelica sinensis (female ginseng, or dong quai), Withania somnifera (Indian ginseng or ashwagandha), Pfaffia paniculata (Brazilian ginseng), Lepidium meyenii (Peruvian ginseng or maca), Gynostemma pentaphyllum (southern ginseng or jiaogulan). Siberian ginseng is not covered in this review.

Bioactive products found in Panax ginseng

Mechanism of Action


  • Constituents: The major active components of ginseng are a diverse group of steroidal saponins, labeled ginsenosides125,126,127, the mechanisms of which are still largely unknown. Ginsenosides are thought to be adaptogenic and are transformed into pharmacologically active substances (compound K or M4) by intestinal microorganisms.128 Compound K is derived from protopanaxadiol ginsenosides, whereas M4 is derived from protopanaxatriol ginsenosides. Recent reports show that ginsenosides act as pro-drugs for these metabolites and that the ginsenoside Rg2 regulates human 5-hydroxytryptamine3A receptor channel activity.129 Every part of the plant has pharmacological action. However, the root is most commonly used and has higher ginsenoside content.130 Generally, the saponin content is higher in Panax notoginseng and Panax quinquefolius than in Panax ginseng.131 However, there is controversy in this area as some believe that Panax ginseng has a higher saponin content, which is why it is considered stronger than American ginseng. Oriental red ginseng was found to have a low concentration of ginsenosides in one study.79 Methylxanthines (caffeine, theophylline, theobromin, and others) were extracted from a commercial sample of ginseng supplements in one study.132
  • Ginseng components include 20(S)-Ginsenoside Rg3, acetylenic alcohol, aglycones, alpha-maltosyl-beta-D-fructofuranoside, aluminum, antioxidants, calcium, chikusetsaponin-L8, citral, cobalt, copper, dammarane-type tetracyclic triterpenoid saponins, essential amino acids (especially arginine), fatty acids, ginsenan PA, ginseng acidic polysaccharide, ginsenosides (e.g., F1, F2, F3, R0, Ra1, Ra2, Rb1, Rb2, Rb3, Rc, Rd, Rd2, Re, Rf, Rg1, Rg2, Rg3, Rh1, Rh2, Rh3, and Rs4), notoginsenoside-Fe, ginsenoside-Ia, ginsenoside-Ra1, ginsenoside-Re, ginsenoside-Rg2 (20R), ginsenoside-Rh1 (20R), ginsenoside-Rh1 (20S), ginsenoside-Rs3, iron, limonene, manganese, magnesium, molybdenum, notoginsenoside-R4, oleanolic acid, panaxadial, panaxans, panaxatriol, panaxosides, panaxydol, panaxytriol, peptidoglycans, phosphorus, polyacetylenes, polyacetylenic compounds, poly-furanosyl-pyranosyl-saccharides, polysaccharides, potassium, protopanaxatriol, protopanaxadiol ginsenosides, quinqueginsin, saponins, sodium, terpineol, triterpenoids, vanadium, vitamins (especially ascorbic acid and B vitamins), volatile oil (b-elemene, panaxydol, panaxytriol, falcarinol, and falcarintriol), and zinc.49,14,133,134,135,136,137,138,139
  • In various chemical analyses, shenmai has been found to contain up to 39 ginsenosides as well as seven ophioponins.16,17
  • Panax ginseng: Panax ginseng has much higher amounts of Rg1 than American ginseng, which has more Rb1. Rg1 and Rb1 are thought to have opposing pharmacological roles. Rg1 is thought to be a slight central nervous system stimulant (activates brain activity), hypertensive, anti-fatigue agent, anabolic (stimulates deoxyribonucleic acid (DNA), protein, and lipid synthesis), and mental acuity and intellectual performance enhancer.
  • American ginseng (Panax quinquefolius): This herb's constituents include poly-furanosyl-pyranosyl-saccharides.52 American ginseng typically has higher levels of ginsenoside Rb1 and no ginsenoside Rf. Ginsenoside Rb1 is believed to limit or prevent the growth of new blood vessels, depress the central nervous system (anticonvulsant, analgesic, tranquilizing), and have hypotensive, anti-stress (protecting gastrointestinal tract from ulcers), antipsychotic (inhibition of conditioned avoidance response), weak anti-inflammatory, and antipyretic (fever-reducing) activity, as well as facilitate small intestine motility, and increase liver cholesterol synthesis. American ginseng is thought to be higher in acidic, or malonyl, ginsenosides.140 Malonyl and neutral ginsenosides are reduced when drying temperature is raised from 32-44°C.141
  • Alcohol clearance effects: Ginseng improves alcohol clearance in humans by 30-50%, likely by enhancing metabolic activity of alcohol dehydrogenase.111
  • Analgesic effects: In a two-phase formalin pain test, 23 ICR mice fed orally with polyfuranosyl-pyranosyl-saccharides extracted from American ginseng root (Cold-fX®) for four days spent significantly less time in licking and biting their injured paws in the second phase of pain than the water-fed placebo mice.39 There was no difference in the first phase of pain between the groups. In animal studies, ginseng total saponins antagonized morphine-induced analgesia, an action that also inhibits the development of analgesic tolerance to and physical dependence on morphine.104 In mice, ginseng has been shown to inhibit tolerance formation to opioids and psychostimulants.115,44 Ginsenosides administered intrathecally, intraperitoneally, or intracerebroventricularly have also produced analgesia against capsaicin-induced pain in mice.142
  • Angiogenic effects: In in vivo and in vitro studies, Rg1 and Re, compounds isolated from Panax ginseng, significantly increased human umbilical vein endothelial cell proliferation, migration, formation of a capillary-like network of cells, and increased neocapillary density.143,33 In addition, shenmai may also have angiogenic effects, as low-dose shengmai chenggu capsule-treated rabbit serum significantly stimulated vascular endothelial growth factor (VEGF) secretion of the ECV304 human umbilical cord cells in vitro .144 However, Panax ginseng is traditionally used to treat cancer and is thought to have antiangiogenic effects.31
  • Angiotensin-converting enzyme (ACE) effects: In an in vitro study, Panax ginseng extract inhibited angiotensin-converting enzyme (ACE) activity, but did not affect nitric oxide (NO) production.110
  • Antiaging effects: The combination of Panax ginseng C.A. Meyer and du-zhong leaf stimulates collagen synthesis and prevents the decrease in protein metabolism that occurs with aging.145
  • Antiallergic effects: In laboratory studies, ginsenoside Rh2 has exhibited antiallergic activity originating from cell membrane-stabilizing activity and anti-inflammatory activity by the inhibition of nitric oxide (NO) and PGE2 production.102
  • Antiasthmatic effects: An in vitro study indicates that ginsenoside induces relaxation of human bronchial smooth muscle via stimulation of nitric oxide (NO) generation, predominantly from airway epithelium and cyclic guanosine monophosphate (GMP) synthesis.13
  • Anti-cancer effects: Antineoplastic effects of ginseng have been found in vitro, in vivo146, 147,148,149,30,150,151,152,153,154,155, and in epidemiological studies29. The nature of this mechanism is poorly understood, but ginsenosides Rg3, Rg5, and Rh2 are active components that may prevent cancer either singularly or synergistically.156
  • In epidemiological study, ginseng consumers had a decreased risk for most cancers compared with nonconsumers.157,158,159,160 Preliminary evidence suggests that patients treated with ginseng plus chemotherapy showed symptomatic improvements in their general condition (fewer symptoms, improved appetite, weight gain), but also improvements in various clinical parameters (hemoglobin, immunoglobulin, and lymphocyte levels).161 This has not been confirmed with a primary reference.
  • Saponins, polysaccharides, and polyacetylenes are likely to contribute and possibly to act in synergy on neoplastic processes162 and may act as immunomodulators163. Constituents of ginseng have been shown to inhibit the production of tumor necrosis factor in mouse skin36, inhibit the growth and proliferation of cancer cells in animal models 98, inhibit cell proliferation, induce differentiation, and stimulate c-fos expression, intracellular cAMP, p21 and p53 expression, mitomycin C accumulation, caspase-1 activation, caspase-3 activation, Bax upregulation, and interferon levels, and reduce levels of cyclin D protein, and activity of cyclin/Cdk complex kinase activity, phosphorylation of pRb, and E2F release, in vitro164,9,114. Another laboratory study indicates that (20S)Rg3 prevents endothelial cell apoptosis via Akt-dependent inhibition of the mitochondrial apoptotic signaling pathway.32 Other tumor cell processes may also be interfered with by ginseng constituents or their intestinal bacteria metabolites.99,165
  • Panax quinquefolius L. was found to synergistically inhibit cancer cell growth when used in combination with breast cancer therapeutic agents (cytoxan, doxorubicin, fluorouracil, methotrexate).166 Triol saponins in combination with polysaccharides from Korean red ginseng exhibit a protective effect on the formation and growth of tumors in mice.167
  • Cell line study of a related species showed that Panax japonicus, which contains saponins (chikusetsusaponins IV, IVa, V, polysciasaponin P5), may relieve cutaneous symptoms caused by excessive apoptotic cell death in the skin through the Fas/FasL pathway.168
  • Shengmai injection has also shown anti-tumor effects in mice.169 The inhibition mechanism might be related to IL-2 receptor levels.170
  • The role of cancer-preventative effects of ginseng have been discussed in various reviews.171,162
  • Antiemetic effects: The results of an in vitro study indicate that ginseng saponins, especially the panaxatriol saponin fraction, have substantial inhibitory effects on the recombinant serotonin type 3A receptor, suggesting that some specific ginsenosides might have an antagonistic action against serotonin type 3A receptor related to nausea and vomiting.12 These antiemetic results are supported by an animal study using Korean red ginseng total extract.28
  • Anti-inflammatory effects: Panax ginseng may reduce muscle injury and inflammation following exercise in humans, as demonstrated by reduced levels of creatine kinase, beta-glucuronidase, and glucose-6-phosphate dehydrogenase (G6PDH) following oral Panax ginseng administration.172 In a clinical trial of patients with obstructive jaundice, postoperative Salvia miltiorrhiza and shengmai decreased the postoperative levels of plasma LPs, ET, TNF-alpha, IL-6 and IL-8, and inhibited inflammatory mediator and improved blood dynamics.42 Administration of shenmai injection also significantly reduced the expression of TNF-alpha mRNA in peritoneal macrophages.173
  • Antimicrobial effects: In an animal study, mice treated with ginseng before a bacterial challenge of Staphylococcus aureus were protected from sepsis, possibly due to early suppression of acute inflammatory responses and later enhancement of macrophage activity.174 Juzen-taiho-to, a Japanese traditional medicine containing ginseng radix, enhanced the anti-Candida activity of macrophages in Candida albicans infected mice.175 Belogortseva et al. found polysaccharide fractions from the root of Panax ginseng to inhibit Helicobacter pylori hemagglutination.176 Patients treated with ginseng exhibited a significant improvement in clearance of Pseudomonas aeruginosa from the lungs (p<0.04), lower lung abscess incidence (p<0.01), and lower mast cell numbers in the lung foci (p<0.005).34
  • Antioxidant effects: Panax ginseng and Panax quinquefolius have antioxidant activity.177,19 This is thought to be due to ginsenoside content178 and saponins, which can decrease oxidation of low density lipoprotein in vitro122, 179. In addition, Panax ginseng extracts have antioxidant activity in vitro in brain tissue180, and its properties may be enhanced by using a heat treatment on the ginseng36. Benzoic acid derivatives, salicylic acid, and vanillic acid also showed antioxidant activity in assays.181 Not surprisingly, shenmai (Panax ginseng, Schizandra fruit, Ophiopogon) has also shown antioxidant activity in vitro, in rats, and in heart attack patients.46, 182 Lee et al. found a reduction of oxidative deoxyribonucleic acid (DNA) damage and protein oxidation in smokers who were supplemented with ginseng183, the compounds that mediate such effects remains unclear.
  • Antiplatelet aggregation effects: Ginseng acts as an antagonist to platelet activating factor84 and dose-dependently to thrombin87, which may be due primarily to ginsenoside Rg17 or panaxynol89. Ginseng inhibits platelet aggregation regulation of cGMP and thromboxane A2 levels. The platelet aggregation inhibiting action of ginseng may mediate its therapeutic effect in diabetic nephropathy.81 In addition to inhibiting aggregation of rabbit platelets, panaxynol, a compound found in Panax ginseng, inhibits the release reaction and thromboxane formation, while ginsenosides R0, Rg1, and Rg2 only suppress the release reaction.88 Furthermore, dietary supplementation of rats with the lipophilic fraction from Panax ginseng has an antithrombotic effect.86
  • In vitro, notoginsenoside R1 can induce a profibrinolytic response85 and R0 and Rg1 decrease the creation of fibrin and stimulate fibrin antagonistic enzymes90.
  • On the other hand, in a hemorrhagic rat model, Panax notoginseng (powder and total saponin extract) applied topically exhibited a hemostatic effect.82 The Korean herbal combination medicine dae-jo-hwan, which contains Panax ginseng Meyer, showed similar anti-thrombotic characteristics.11 Panax quinquefolius also exhibits antithrombotic activity in vitro, which may be due to nitric oxide (NO) release.83 However, co-administration of warfarin with ginseng did not affect the pharmacokinetics or pharmacodynamics of either S-warfarin or R-warfarin.184 Likewise, in a small randomized, controlled study, co-administration of Panax ginseng and warfarin did not influence the pharmacologic action of warfarin in ischemic stroke patients without a history of warfarin use.105
  • Antiulcer effects: A polysaccharide fraction of the leaves from Panax ginseng prevented gastric ulcer formation in rats after administration of necrotizing agents (HCl-ethanol, ethanol) and after pylorus ligation.185 This effect was observed not only after oral, but also after systemic administration, suggesting a non-local effect. Rats administered tissue cultured and cultivated ginseng had reduced gastric secretion and acid output.186 However, pepsin activity was not affected. Specifically, the cultivated ginseng blocked histamine induced acid secretion.
  • Antiviral effects: A few studies indicate that ginseng may have antiviral activity in both humans and animals. When given in combination with 6-MFA, an interferon inducing antiviral agent, ginseng was found to protect 82-100% of mice infected with Semliki forest virus.187 Ginseng also has a level of effectiveness similar to that of zanamivir and oseltamivir, and may reduce duration of a cold.52
  • Aphrodisiac effects: Traditionally, ginseng has been used as an aphrodisiac and some research supports this. It is thought that Panax ginseng enhances nitric oxide synthesis in corpora cavernosa endothelium and ginsenosides enhance acetylcholine-induced and transmural nerve stimulation-activated relaxation associated with increased tissue cyclic guanosine monophosphate.38
  • Cardiovascular effects: Ginsenoside-induced smooth muscle relaxation57,61,62,63 might explain the improvement of symptoms of coronary artery disease including typical electrocardiogram (ECG) changes, such as repolarization disturbances188. Implications have been made that Ca2+ plays a role in ginseng's cardiovascular effects.189,62 Ginsenosides Rb1 and Rg1 appear to have vasodilatory effects, possibly mediated by the proportion of nitric acid release.61 Enhanced nitric oxide synthesis from the endothelium of the lung, heart, kidney, and corpus cavernosum contributes to the vasodilation.3 The total saponins of Panax notoginseng may improve myocardial relaxation secondary to an enhancement of the calcium pump activity and inhibiting intracellular calcium overload.190
  • The left ventricular function was improved in rats that were administered yi-qi huo-xue, consisting of ginseng, astragalus, and Angelicae sinensis.191 Panax notoginseng saponins inhibit the proliferation of aortic smooth muscle cells stimulated by hypercholesterolemic serum.192 Rats treated with ginseng were less susceptible to arrhythmias than controls.193 Panax ginseng and American ginseng were found to increase the higher harmonic Fourier components of the pulse.58 Rb1 decreases the contraction force in pigs without affecting the action potential or amplitude.194 Rg 1 and Re showed vasodilator action in dogs, while Rc and Rb2 only showed very weak vasodilator actions but Rb1 did not.57 In dogs, ginseng aqueous extract significantly decreased the cardiac output, stroke volume, and central venous pressure and significantly increased the total peripheral resistance.60 Although both red and white ginseng similarly affect the cardiovascular system, red ginseng has stronger effects than white.195
  • In congestive heart failure patients, shengmai injection (Panax ginseng, Schizandra fruit, Ophiopogon) lowered serum levels of DR4 and DR5, the death receptor of soluble tumor necrosis factor-related apoptosis inducing ligand (TRAIL).196 Shengmai powder may also improve left ventricular performance in cases of coronary heart disease.197,198 Shenmai injection has also increased cardiovascular output in another clinical trial.97 In addition, shenmai injection in rats had a marked protective effect in systemic inflammatory reaction syndrome (SIRS), which might be related to the lowering of lipopolysaccharide levels and reducing of tumor necrosis factor (TNF) alpha secretion in rats.35
  • In vitro study indicates that ginsenoside Re from Panax ginseng uses nitric oxide (NO) actions to increase cardioprotection, specifically through direct S-nitrosylation of channel proteins to enhance K+ current and utilizing a cGMP-dependent pathway to suppress L-type Ca2+ current.199
  • Cellular effects: A polysaccharide from the root of Panax notoginseng has reticuloendothelial system activating properties.200 According to evidence from an assay, various ginsenosides have different effects on intracellular gap junction-mediated intercellular communication (GJIC), including inducing GJIC reductions and inhibiting GJIC reductions, due to tyrosine phosphatase inhibitor vanadate or interleukin 1 alpha (IL-1alpha).14 Panax ginseng may improve nitric oxide synthesis in endothelium of the heart, lung, kidneys, and in the corpus cavernosum.73 Ginsenosides Rh2 and Rh3 can induce differentiation of HL-60 cells into granulocytes.201 Modulation of protein kinase C isoform levels may contribute to differentiation of HL-60 cells by Rh2.
  • Cerebroelectrical effects: Panax ginseng can directly modulate cerebroelectrical activity, based on encephalographs of healthy volunteers.21
  • Cholesterol effects: Ginseng may possess lipid-lowering properties. In animals and hyperlipidemic humans, oral administration of ginseng reduced plasma total cholesterol, triglyceride, LDL-cholesterol, and non-essential fatty acids, while increasing levels of HDL91,202, which may be due to the stimulation of cholesterol enzymes203. Another study found ginseng to lower blood triglyceride levels in obese rats compared to controls.204 Although ginsenoside Re may reduce cholesterol, Rb1 may actually raise it.203 Cholesteryl ester transfer protein inhibitors inhibit human cholesteryl ester transfer protein with IC50 values of 20-35mg/mL.205 No effect on plasma lipids was found in a study on type 2 diabetics.76
  • Circulation effects: Shenfu injection (ginseng and aconite root) increased the auricle micro-artery diameter and the density of capillary and blood velocity in mice, more so than shenmai injection.206
  • CNS/Neurological/Cognitive effects: CNS stimulating effects have been found in animal models for ginseng extracts207 and for all studied ginsenosides alleviating fatigue57. The ginsenoside Rb1 may exert its memory effects by minimizing the inhibitory effects of β-amyloid peptides, thought to play a role in memory degeneration208, although neither Rb1 nor Rg1 reversed β-amyloid-induced cell death209. Rb1 and Rg1 increased neuron growth and reversed 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-induced cell death.209 Panax ginseng extract also improves amnesia induced by scopolamine administration.210, 211 In mice, ginseng has been shown to have anxiolytic properties.212 In rats, ginseng has been shown to antagonize the acute pharmacological actions of morphine.213 and to inhibit the development of morphine tolerance44. Ginsenosides Rb1 and Rg1 were found to inhibit hyperactivity, conditioned place preference, and postsynaptic dopamine receptor supersensitivity in mice.116 These observations indicate a possible use of ginseng in the treatment of drug dependence.115
  • The metabolism of dopamine and norepinephrine in the cerebral cortex and serotonin in the corpus striatum and cerebellum was enhanced in mice that were administered Panax ginseng root.214 Dopamine in the corpus striatum and serotonin in the hypothalamus and midbrain were inhibited. However, mice treated for seven weeks had inhibited metabolism of dopamine, norepinephrine, and serotonin in all brain areas with the exception for the enhancement of serotonin metabolism in the cerebellum. Ginseng extract also inhibits the uptake of gamma-amino butyric acid (GABA), glutamate, dopamine, noradrenalin, and serotonin in rat brain synaptosomes.215 An in vitro study suggested that ginsenosides regulated GABA(A) receptor expressed in Xenopus oocytes and implied that this regulation might be one of the pharmacological actions of Panax ginseng.216 Ginseng total saponin 100mg/kg decreased the release of striatal dopamine induced by intrastriatal nicotine infusion by 41%.217 Ginseng is thought to normalize disturbances in the sleep-wake cycle218 and Rb1, Rb2, and Rc ginsenosides can prolong hexobarbital sleeping time and exhibit additional depressant effects on the central nervous system (CNS) in mice.
  • Consumption of a softdrink containing ginseng and ginkgo extract resulted in alterations in electroencephalogram (EEG) recordings from healthy human volunteers.219 In an in vitro study, American ginseng extract tonically and reversibly blocked the Na(+) channel in a concentration- and voltage-dependent manner, possibly due to an interaction with the channel when it was inactive.120 Ginsenoside Rb1 alone had similar results to the total extract. These results, and the results from another in vitro study, indicate that American ginseng may protect neurons from oxidative and ischemic injury.220 Shenmai (Panax ginseng, Schizandra fruit, Ophiopogon) has also shown protective effects in rats after cerebral ischemia-reperfusion injury, circulatory shock, and brain damage during heatstroke.15,221,222,37 An explanation for this effect is due to shenmai's antioxidant activity.15,221,222,37 A rat study has also shown that sensory nerve conduction velocity increased after shenmai huoxue decoction administration in a diabetes model.40 In animal study, shenmai (ginseng, Ophiopogon, and Schisandra) may offer protective effects in intracerebral hemorrhage223 and neurocytes224.
  • Although human study has indicated that ginseng increases cognitive performance23, the mechanisms of this effect are not known, but may be related to the ginseng's glycemic properties22,93. Ginseng affects brain activity, specifically by increasing cortical levels of dopamine, noradrenalin, serotonin, and cAMP.214 In vitro study indicates that ginseng increases energy produced aerobically in the brain.225 Ginseng saponins showed moderate depressant actions on the EEG and the behavior in cats, although Rg1, Re, and Rb2 were more potent than the other saponins.57
  • Cytotoxic effects: Although some Panax ginseng root polysaccharides may have cytoprotective activity226, more research has been conducted on ginseng's cytotoxic effects. In in vitro study, ginseng's etheric oil and ginsenoside aglycones 20(S)-protopanaxadiol, 20(S)-protopanaxatriol, and ginsenoside Rh2 have been identified as having a strong cytotoxic effect on intestinal and leukemia cell growth.43,65,227 Panaxytriol has also been found to rapidly inhibit cellular respiration and disrupt cellular energy balance in breast cancer cells.228 However, another in vitro study did not find a cytotoxic effect in monocytes from patients with AIDS or chronic fatigue syndrome.229
  • Cytochrome P450 (CYP) effects: Based on the available evidence, Panax ginseng does not appear to alter CYP450 metabolism. In vitro, ginsenosides found in Panax ginseng have no inhibitory effects on CYP3A activities103, yet their intestinal bacterial metabolite possesses the potential for inhibitory effects on CYP3A activities117. No significant effect on CYP activity was observed for Panax ginseng in a clinical trial.230 C57BL/6J mice treated for three days with 5g/kg daily of CVT-E002, a proprietary extract from American ginseng (Panax quinquefolius), showed no effects on liver microsomal CYP catalytic activities.118 Based on in vitro laboratory studies, human hepatic recombinant cytochrome P450 (CYP) drug metabolizing isozymes 1A2, 2B6, 2C19, 2C9, 2D6, and 3A4 demonstrated no effect on activity by Cold-fX® over a wide concentration range.119
  • Dermatologic effects: The saponin content of ginseng radix rubra accelerates fibronectin synthesis through changes in transforming growth factor-β receptor expression in fibroblasts.231 This action is thought to facilitate wound healing. Topical application of an extract obtained from Korean red ginseng increases the fibronectin in the whole dermis (in mice), deoxyribonucleic acid (DNA), and protein synthesis (in human fibroblasts).232
  • Endocrine effects: Some clinicians still believe that there is a lack of evidence to attribute ginseng with a glycemic effect233, due to methodological flaws of studies234. Ginseng appears to have an insulin-mimetic78, hypoglycemic effect in type 2 diabetes, possibly accelerating glucose-utilization by the liver77,75. This hypoglycemic effect has also been seen in nondiabetic human subjects taking American ginseng74,75, although one study found no such effect, perhaps due to variable ginsenoside concentrations in the Panax ginseng used70,112. Although a hypoglycemic effect of ginseng was also found on postprandial glucose levels in healthy subjects in another study, no hypoglycemia was observed.75 Similarly, Panax ginseng (G115) significantly lowered fasting blood glucose levels; however, effects on blood glucose were opposite in the raised blood glucose state.94 One study suggests that the glycemia-lowering effect of American ginseng root may be batch dependent.235 40% of batches tested did not reduce glycemia with the anticipated magnitude. Several types of ginseng (Canadian white, American red, Korean red, and Sanchi ginseng) decrease plasma glucose levels79, possibly due to their sulfonylurea-like activity69.
  • Furthermore, ginseng seems to accelerate hepatic lipogenesis, stimulate glucose transport, enhance glycogen storage, inhibit lipolysis, and inhibit lipid peroxidation.76,236,78,101 Ginseng may elicit an elevation of plasma insulin level by increased insulin secretion from beta islet with a differing mechanism from glucose.71. At least five glycans have been isolated from Panax ginseng237 and three from Panax quinquefolius238. A small study found 50g of ginseng extract to have no effect on insulin after a standardized weight-training workout.239 Ingestion of 3g American ginseng daily for eight weeks significantly lowered fasting plasma plasminogen activator inhibitor-1.72 There is a strong relationship between glycemic control and the plasminogen activator inhibitor-1.
  • Shenfu decoction (ginseng and aconite root) and shengmai powder (ginseng root, Ophiopogon japonicus root, Schisandra chinensis fruit) had no regulating effect on blood glucocorticoid levels in hemorrhagic rats (Qi-Yang exhaustion model) or heat-stressed rats (Qi-Yin exhaustion model), but upregulated glucocorticoid receptor levels.240
  • In rats, ginseng saponin primarily affected the hypothalamus and/or hypophysis and increased corticosterone levels in the adrenal cortex by stimulating corticotropin secretion.241 Panax ginseng extract also had an affinity for progestin, mineralocorticoid, and glucocorticoid receptors.242
  • Exercise effects: American ginseng supplementation before exhaustive aerobic exercise reduced creatine kinase leakage during exercise, but did not change aerobic capacity, possibly due to American ginseng's ability to reduce cellular and muscle damage.18
  • Fertility effects: Panax notoginseng extracts enhanced sperm motility in vitro after one and two hours of incubation.243 Ginsenosides enhanced nitric-oxide release from nitrergic nerves in tissue samples of rabbit corpus cavernosum244,2 and caused relaxation of the smooth muscle245. Choi et al. found that long-term administration of Korean red ginseng enhanced erectile capacity by endothelium-derived relaxing factor.246 Use of Panax ginseng C.A. Meyer extract showed an increase in spermatozoa number/mL and progressive oscillating motility, an increase in plasma total and free testosterone, dihydrotestosterone (DHT), follicle stimulating hormone (FSH), and luteinizing hormone (LH) levels, but a decrease in mean prolactin (PRL).108 In another clinical trial, Panax ginseng decreased in the percentage of diskinetic forms of spermatozoids.107
  • Helicobacter pylori inhibitory effect: Acidic polysaccharides from Panax ginseng may inhibit Helicobacter pylori adhesion to human gastric epithelial cells.41
  • Hemological effects: Saponins from Panax ginseng, including ginsenosides Rb1, Rb2, and Rg1, inhibited the hyperosmotic hemolysis of erythrocytes in an in vitro study.247 In an in vitro trial using bone marrow from patients with aplastic anemia, the total saponins of Panax ginseng increased bone marrow cultures possibly by prompting proliferation of normal progenitor cells.248 In a clinical study, shenmai injection (Panax ginseng, Schizandra fruit, Ophiopogon) decreased the concentration of tumor necrosis factor (TNF)-alpha in blood serum and the apoptosis rate of bone marrow CD34. cell249
  • Hepatoprotective effects: The metabolite of oral ginsenosides, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, protected mouse liver cells from cytotoxicity induced by tert-butyl hydroperoxide and significantly inhibited the increment of alanine amino transferase (ALT) and aspartate transaminase (AST) induced by tert-butyl hydroperoxide in mice.250 The metabolite also stabilized cell membranes.
  • Hormonal effects: The estrogenic effects of ginseng are not well defined, due to conflicting studies. Some in vitro studies indicate an estrogenic effect in human breast cancer cells, possibly by binding and activating the estrogen receptor.64,251,109,10,67,252 Other in vitro studies do not show this effect.66 This discrepancy may be due to the type of ginseng extract used, as King et al. showed that a methanol extract did have estrogenic properties in vitro in breast cancer cells, but a water extract did not.8 The traditional Japanese herbal medicine unkei-to, which contains Panax ginseng and other herbs, stimulated the secretions of 17ß-estradiol and progesterone from highly luteinized granulosa cells obtained from in vitro fertilization patients; the stimulated effect on estradiol secretion occurred with 0.3mcg/mL, while a significant effect on progesterone secretion was obtained at 10mcg/mL.50
  • Ginseng has been postulated to stimulate adrenocorticotropic hormone and thereby increase plasma cortisol levels.123 In rats fed with ginseng for 60 days, a significant increase of blood testosterone levels was found, combined with a significantly reduced prostate weight.124 An estrogen-like effect of ginseng may be due to strong competition with estradiol for estrogen and progesterone binding sites in the human myometrial cytosol.253 One study was conducted to determine whether ArginMax® (The Daily Wellness Co., Sunnyvale, CA) or the Panax ginseng extract it contains has any estrogenic activity.66 ArginMax® for Women, a nutritional supplement for sexual health, contains L-arginine, ginseng, ginkgo, damiana, multivitamins, and minerals. In a human endometrial adenocarcinoma cell line, no estrogenic activity was evident in either ArginMax® or Panax ginseng.
  • Hypotensive effects: There has been conflicting research on the effect of ginseng on blood pressure. In hypertensive individuals, 3g American ginseng had a neutral effect on all ambulatory blood pressure parameters compared with placebo, and had no effect on 24-hour blood pressure and renal function in hypertensive individuals.95,113 In another clinical trial, Panax ginseng extract 200mg daily increased the QTc interval and decreased diastolic blood pressure two hours after ingestion in healthy adults on the first day of therapy, but these effects were not considered clinically significant.59 Other authors have also described hypertensive effects of ginseng.53,54 The conflicting effects of ginseng on blood pressure may be due to the dosage used.62,254,60,54
  • The hypotensive effects in humans55,58 and animals60 may be due to a relaxing effect on smooth muscle induced by certain ginsenosides (e.g., Rb1)57,61,62,63. An animal study indicated that ginseng has simultaneous contraction and relaxation effects that may explain ginsenosides' biphasic actions on blood pressure.56,57
  • Immunomodulating activity: Both suppression and enhancement of humoral and cellular immunity have been reported, due to ginseng extracts.25,255 This discrepancy could arise from the difference in dose levels, composition, and duration of therapy. Ginseng is believed to boost immune function and, thus, has been implicated for treatment of cancer and respiratory infectious disease.256 In human or animal study, ginseng has been shown to enhance cellular immune function by stimulating natural killer cell activity257,258,259,229,157, macrophages25, tumor necrosis factor (TNF)-alpha production260, cytokine production261,26, antibody-dependent cellular cytotoxicity229,96, intracellular killing in neutrophils, blastogenesis of circulating lymphocytes262, increased antibody production257, potentiation of the effect of vaccines263, exhibition of anticomplement activity254, or exhibition of mitogenic activity towards lymphocytes264. Study suggests a lack of effect on peripheral blood leukocyte numbers and lymphocyte subsets after administration of ginseng.265
  • Immunomodulating effects of ginseng may be attributable to constituents, such as root-derived panaxanes-polysaccharides266, ginsenosides that can differentially modulate lymphocyte proliferation267, and ginsenan S-IIA, a potent inducer of IL-8 production by human monocytes and THP-1 cells268. Certain multi-ingredient preparations, such as CKBM (Panax ginseng, Schisandra chinensis, Fructus crataegi, Ziziphus jujube, and Glycine max), have also been shown to regulate intracellular signaling and the production of cytokines.24
  • The immuno-regulatory functions of a saccharide-rich proprietary American ginseng extract (Panax quinquefolius, CVT-E002) by CV Technologies Inc., may be due to stimulation of a panel of inflammatory cytokines secretion from monocytes, and augmentation of IFN-γ secretion upon influenza stimulation. In clinical study, Cold-fX®, containing CVT-002, demonstrates effectiveness in the prevention and treatment of upper respiratory infections.4,5,100 Cold-fX® may increase NK cell and macrophage activity leading to increased cytolytic and phagocytic killing of pathogens and IFN-γ secretion. Evidence from in vitro and in vivo studies indicates that Cold-fX® induced antiviral effects could be related to its immunomodulating properties.269,256,270,27,92,271
  • It has been suggested that Korean red ginseng may delay disease progression in human immunodeficiency virus type 1 (HIV-1)-infected patients and slow the decrease in CD4 T cells.272
  • Lipogenesis effects: Ginseng seems to inhibit lipolysis and promote lipogenesis.273,274
  • Nicotinic activity: In an in vitro study, Panax ginseng extract had affinity for both the nicotinic receptor and, to a lesser extent, the muscarinic receptor, but the activity is not due to choline.275 Ginsenosides might regulate nicotinic acetylcholine receptors in a differential manner.276
  • Photosensitivity: In laboratory study, Panax ginseng acted as a photoprotector in low concentration and as a photosensitizer in high concentration.80
  • Protein synthesis effects: In an in vitro study, ginseng stimulated protein synthesis in human fibroblasts.277
  • Protein tyrosine kinase effects: American ginseng ginsenosides and the non-saponin fraction of Panax ginseng roots had significant inhibitory effects on protein tyrosine kinase activation induced by hypoxia/reoxygenation in one laboratory study.134
  • Pulmonary effects: A ginsenoside-induced nitric oxide-mediated relaxation effect has also been observed in vitro in bronchial smooth muscle.13 This offers a possible mechanism for the bronchodilatory effect reported from the only trial that assessed this effect in humans.68 Promotion of nitric oxide release has also been suggested as possible mechanism in the vasorelaxation and prevention of oxygen free radical injury in pulmonary endothelium by ginsenosides.61 These effects appear to be even more pronounced after artificial gastric digestion of extract G115.®278 Shenmai (ginseng, Schizandra fruit, Ophiopogon) has increased the contraction of diaphragmatic muscle in vitro.279,45,280
  • Pulse alteration (TCM): Pulse measurement is seen in traditional Chinese medicine (TCM) as a multifaceted component of heart rate. Single doses of Panax ginseng or Panax quinquefolius extract demonstrated specific effects on the Fourier components of the pulse.58 Panax ginseng and Panax quinquefolius reported significant increases in harmonic components C6, C7, C8, and C9. Western medicine does not view pulse the same way as TCM; therefore, results may not be applicable to a Western idea of pulse and health.
  • Radioprotective effects: Ginseng saponin significantly increased radioprotection when applied to cultured mammalian cells before gamma-irradiation.281 Ginseng has been shown to be radioprotective in mice. One study found specific fractions of ginseng to be attributable for this action: CM-A, G-1, and G-3.282 Panax ginseng also prevents irradiation-induced hair loss due to programmed cell death in the follicles.283
  • Renal effects: In a clinical trial, postoperative Salvia miltiorrhiza and shengmai in patients with obstructive jaundice inhibited inflammatory mediator and improving blood dynamics, thereby protecting renal function.42 This renal protective effect by shenmai injection has also been seen in rats with 5/6 nephrectomy.284
  • Sexual effects: Ginsenosides enhance nitric-oxide release from nitrerigic nerves in tissue samples of rabbit corpus cavernosum244,2 and causes relaxation of the smooth muscle245. In a clinical trial of 90 patients with erectile dysfunction, ginseng saponins changed early detumescence and penile rigidity, penile girth, and libido.106
  • Sleep effects: In rats, ginseng temporarily increased slow wave sleep, although this effect returned to the baseline after two weeks.285
  • Steroid-like effects: In an in vitro trial, Panax ginseng suppressed phytohemagglutinin stimulation of peripheral blood lymphocytes, indicating that Panax ginseng has a steroid-like effect.121
  • Stimulant effects: Panax ginseng extracts contain similar constituents as guarana, a known herbal stimulant.20
  • Stimulatory/growth effects: In in vitro studies, Panax ginseng and heat-treated ginseng stimulated cell growth of human fibroblasts, probably by promoting growth in younger cells.286,1,6 Irradiated animals receiving ginseng experienced accelerated recovery of the megakaryocytes in the bone marrow.48 Ginsenoside Rg1 was shown to increase both humoral and cell-mediated immune responses. Kenarova reported that spleen cells from ginsenosides treated mice injected with sheep red cells as an antigen showed significantly higher plaque-forming response and hemagglutinating antibody titers.287 In addition, Rg1 increased the number of antigen-reactive T helper cells, T lymphocytes, and NK cells.
  • Urinary effects: An International Olympic Committee (IOC) urine drug test of athletes ingesting Cold-fX® was not positive for any IOC banned or restricted substances.51
  • Wound healing effects: Ginseng has been traditionally used for wound healing, and these properties may be due to the activity of ginsenosides Rb1and Rb2. Rb1's contribution may be due to the promotion of angiogenesis by stimulating vascular endothelial growth factor production and increasing hypoxia-inducible factor-1a expression.288 Rb2 may stimulate epidermal cell proliferation and formation by increasing secretion of epidermal growth factor and its receptor, as well as fibronectin, keratin, and collagenase 1.289
  • Other: The pharmacological effects of ginsenosides have been reviewed in several publications.290,47,291 The pharmacological activity and constituents of sanchi ginseng (Panax notoginseng) have also been reviewed.292 The potential for interactions with anti-cancer agents of herbal products, including ginseng, has been reviewed.293


  • The ginsenosides found in ginseng appear to be poorly absorbed, either after both oral and intravenous administration in rats.294,295,296 For example, the bioavailability of Rb1 and Rg1 after oral administration is 0.71% and 3.29%, respectively.294 Other unsubstantiated sources have reported that the bioavailability of beta-sitoserol, a steroid sapogenin, and ginsenoside Rg1 after oral administration to rats was 50-60%. However, intranasal administration may increase absorption.297,298 High elimination in the stomach, large intestine, and liver may contribute to the low bioavailability of these ginsenosides, but low membrane permeability is probably a greater limiting factor294,295, especially as ginsenosides may be passively absorbed by simple diffusion294 or dependent on active transport299. The low absorption rate by the intestinal wall could be enhanced by carbomer and borneol.296 Once absorbed, the distribution of ginsenosides could be described by a two-compartment model.300
  • Although several recent studies have examined the ginsenosides themselves, some researchers have focused on the intestinal metabolites of these compounds, which may have the active processes that medical researchers are interested in, such as antitumor effects. A couple of these metabolites are 20- O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol, known as compound K or IH-901, and 20(S)-protopanaxatriol, known as M4.301,302,303,304 The metabolism of ginsenoside Rb1 to compound K was shown in a rat study by Akao et al., when rats deprived of Eubacterium sp. and orally administered Rb1 had neither compound K nor any other metabolite in their plasma, intestinal tract, or feces; Rb1 was only found in fecal contents and not in the plasma.304
  • Compound K seems to be efficiently removed from blood by the liver301 and showed little excretion in the urine302. Compound K may also be passively absorbed from the digestive tract.302 The ginsenoside Rg1 may have a plasma protein binding of 24% and tissue protein binding of 48% in the liver although confirmation is needed.
  • In a study of rats administered with the metabolite M4, M4 was absorbed from the small intestine, was esterified with fatty acids, then accumulated in tissues, including the lungs and liver.303
  • The metabolism and excretion of the constituents of ginseng has not been extensively studied. It appears that ginsenosides are excreted in the urine only in trace amounts. One study has focused on the pharmacokinetics of shenmai injection (Panax ginseng, Schizandra fruit, Ophiopogon) by tracking the plasma concentrations of the ginsenosides Rg1 and Re after shenmai injection into human volunteers.305 The results indicate that the distribution and elimination of Rg1 and Re were rapid after intravenous infusion, and the pharmacokinetic characteristics indicate a two-compartment model.

  1. Fulder, S. The Root with Two Faces. Healing Arts Press 1993;17-30.
  2. Schardt, D. Ginseng. Nutrition Action Health Letter 1999;26 (4):10-12.
  3. Gillis, C. N. Panax ginseng pharmacology: a nitric oxide link? Biochem Pharmacol 7-1-1997;54(1):1-8. 9296344
  4. Predy, G. N., Goel, V., Lovlin, R., Donner, A., Stitt, L., and Basu, T. K. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. CMAJ 10-25-2005;173(9):1043-1048. 16247099
  5. McElhaney, J. E., Gravenstein, S., Cole, S. K., Davidson, E., O'neill, D., Petitjean, S., Rumble, B., and Shan, J. J. A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults. J Am Geriatr Soc 2004;52(1):13-19. 14687309
  6. Almada, A. L. Ginsenosides to Stimulate the Skin Elastin Synthesis. HerbalGram 2004;(61):37.
  7. Kimura, Y., Okuda, H., and Arichi, S. Effects of various ginseng saponins on 5-hydroxytryptamine release and aggregation in human platelets. J Pharm Pharmacol 1988;40(12):838-843. 2907575
  8. King, M. L., Adler, S. R., and Murphy, L. L. Extraction-Dependent Effects of American Ginseng (Panax quinquefolium) on Human Breast Cancer Cell Proliferation and Estrogen Receptor Activation. Integrative Cancer Therapies 2006;5(3):236-243.
  9. Lee, Y. J., Jin, Y. R., Lim, W. C., Ji, S. M., Cho, J. Y., Ban, J. J., and Lee, S. K. Ginsenoside Rc and Re stimulate c-fos expression in MCF-7 human breast carcinoma cells. Arch Pharm Res 2003;26(1):53-57. 12568359
  10. Lee, Y. J., Jin, Y. R., Lim, W. C., Park, W. K., Cho, J. Y., Jang, S., and Lee, S. K. Ginsenoside-Rb1 acts as a weak phytoestrogen in MCF-7 human breast cancer cells. Arch Pharm Res 2003;26(1):58-63. 12568360
  11. Chang, G. T., Kang, S. K., Kim, J. H., Chung, K. H., Chang, Y. C., and Kim, C. H. Inhibitory effect of the Korean herbal medicine, Dae-Jo-Whan, on platelet-activating factor-induced platelet aggregation. J Ethnopharmacol 12-1-2005;102(3):430-439. 16125889
  12. Min, K. T., Koo, B. N., Kang, J. W., Bai, S. J., Ko, S. R., and Cho, Z. H. Effect of ginseng saponins on the recombinant serotonin type 3A receptor expressed in xenopus oocytes: implication of possible application as an antiemetic. J Altern Complement Med 2003;9(4):505-510. 14499026
  13. Tamaoki, J., Nakata, J., Kawatani, K., Tagaya, E., and Nagai, A. Ginsenoside-induced relaxation of human bronchial smooth muscle via release of nitric oxide. Br J Pharmacol 2000;130(8):1859-1864. 10952675
  14. Zhang, Y. W., Dou, D. Q., Zhang, L., Chen, Y. J., and Yao, X. S. Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions. Planta Med 2001;67(5):417-422. 11488454
  15. Ichikawa, H., Wang, L., and Konishi, T. Prevention of cerebral oxidative injury by post-ischemic intravenous administration of Shengmai San. Am J Chin Med 2006;34(4):591-600. 16883630
  16. Xiaohui, F., Yi, W., and Yiyu, C. LC/MS fingerprinting of Shenmai injection: a novel approach to quality control of herbal medicines. J Pharm Biomed Anal 2-24-2006;40(3):591-597. 16356676
  17. Haijiang, Z., Yongjiang, W., and Yiyu, C. Analysis of 'SHENMAI' injection by HPLC/MS/MS. J Pharm Biomed Anal 2-5-2003;31(1):175-183. 12560062
  18. Hsu, C. C., Ho, M. C., Lin, L. C., Su, B., and Hsu, M. C. American ginseng supplementation attenuates creatine kinase level induced by submaximal exercise in human beings. World J Gastroenterol 9-14-2005;11(34):5327-5331. 16149140
  19. Kim, S. H., Park, K. S., Chang, M. J., and Sung, J. H. Effects of Panax ginseng extract on exercise-induced oxidative stress. J Sports Med Phys Fitness 2005;45(2):178-182. 16355078
  20. Kennedy, D. O., Haskell, C. F., Wesnes, K. A., and Scholey, A. B. Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Pharmacol Biochem Behav 2004;79(3):401-411. 15582012
  21. Kennedy, D. O., Scholey, A. B., Drewery, L., Marsh, V. R., Moore, B., and Ashton, H. Electroencephalograph effects of single doses of Ginkgo biloba and Panax ginseng in healthy young volunteers. Pharmacol Biochem Behav 2003;75(3):701-709. 12895688
  22. Reay, J. L., Kennedy, D. O., and Scholey, A. B. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol 2005;19(4):357-365. 15982990
  23. Scholey, A. B. and Kennedy, D. O. Acute, dose-dependent cognitive effects of Ginkgo biloba, Panax ginseng and their combination in healthy young volunteers: differential interactions with cognitive demand. Hum Psychopharmacol 2002;17(1):35-44. 12404705
  24. Chan, A. S., Yip, E. C., Yung, L. Y., Pang, H., Luk, S. C., Pang, S. F., and Wong, Y. H. CKBM stimulates MAPKs but inhibits LPS-induced IFN-gamma in lymphocytes. Phytother Res 2006;20(9):725-731. 16775808
  25. Scaglione F, Cogo R, Cocuzza C, and et al. Immunomodulatory effects of Panax ginseng C.A.Meyer (G115) on alveolar macrophages from patients suffering with chronic bronchitis. Int J Immunother 1994;10(1):21-24.
  26. Spelman, K., Burns, J., Nichols, D., Winters, N., Ottersberg, S., and Tenborg, M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern Med Rev 2006;11(2):128-150. 16813462
  27. Predy, G. N. and et al. Immune modulating effects of daily supplementation of COLD-fX (a proprietary extract of North Amercian ginseng) in healthy adults. J.Clin.Biochem.Nutr. 2006;39:162-167.
  28. Kim, J. H., Yoon, I. S., Lee, B. H., Choi, S. H., Lee, J. H., Lee, J. H., Jeong, S. M., Kim, S. C., Park, C. K., Lee, S. M., and Nah, S. Y. Effects of Korean red ginseng extract on cisplatin-induced nausea and vomiting. Arch Pharm Res 2005;28(6):680-684. 16042077
  29. Larsen, H. R. Ginseng in Cancer Prevention. Alive: Canadian Journal of Health & Nutrition 1998;(193):32-34.
  30. McCaleb, R. Mammary Cancer Suppression By Kampo Medicines. HerbalGram 1994;(32):13.
  31. Yance, D. R., Jr. and Sagar, S. M. Targeting angiogenesis with Integrative Cancer Therapies. Integr.Cancer Ther 2006;5(1):9-29. 16484711
  32. Min, J. K., Kim, J. H., Cho, Y. L., Maeng, Y. S., Lee, S. J., Pyun, B. J., Kim, Y. M., Park, J. H., and Kwon, Y. G. 20(S)-Ginsenoside Rg3 prevents endothelial cell apoptosis via inhibition of a mitochondrial caspase pathway. Biochem Biophys Res Commun 10-27-2006;349(3):987-994. 16962070
  33. Huang, Y. C., Chen, C. T., Chen, S. C., Lai, P. H., Liang, H. C., Chang, Y., Yu, L. C., and Sung, H. W. A natural compound (ginsenoside Re) isolated from Panax ginseng as a novel angiogenic agent for tissue regeneration. Pharm Res 2005;22(4):636-646. 15846472
  34. Song, Z., Johansen, H. K., Faber, V., Moser, C., Kharazmi, A., Rygaard, J., and Hoiby, N. Ginseng treatment reduces bacterial load and lung pathology in chronic Pseudomonas aeruginosa pneumonia in rats. Antimicrob Agents Chemother 1997;41(5):961-964. 9145852
  35. Wei, Y. L., Li, Y. J., and Liu, X. [Experimental study of protective effect of shenmai injection on endotoxin induced systemic inflammatory reaction syndrome and multiple organ dysfunction syndrome]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2001;21(1):47-50. 12577379
  36. Keum, Y. S., Park, K. K., Lee, J. M., Chun, K. S., Park, J. H., Lee, S. K., Kwon, H., and Surh, Y. J. Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng. Cancer Lett 3-13-2000;150(1):41-48. 10755385
  37. Ichikawa, H., Wang, X., and Konishi, T. Role of component herbs in antioxidant activity of shengmai san--a traditional Chinese medicine formula preventing cerebral oxidative damage in rat. Am J Chin Med 2003;31(4):509-521. 14587874
  38. Sandroni, P. Aphrodisiacs past and present: a historical review. Clin Auton Res 2001;11(5):303-307. 11758796
  39. Yang, Y. Z., Chen, R. Z., and Zhang, J. N. [Observation on collaborative treatment of dilated cardiomyopathy]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2001;21(4):254-256. 12577349
  40. Xue, H. L., Wang, W. J., and Chen, J. Q. [Effects of Shenmai Huoxue Decoction on early diabetic peripheral neuropathy in rats]. Zhong Xi Yi Jie He Xue Bao 2005;3(1):31-34. 15644157
  41. Lee, J. H., Park, E. K., Uhm, C. S., Chung, M. S., and Kim, K. H. Inhibition of Helicobacter pylori adhesion to human gastric adenocarcinoma epithelial cells by acidic polysaccharides from Artemisia capillaris and Panax ginseng. Planta Med 2004;70(7):615-619. 15254854
  42. Peng, B., Du, J., Jia, Q., Qiao, A., Wu, Y., Liu, X., and Qiang, Q. [The effect of salvia miltiorrhiza and shengmai on inflammatory mediator and renal function of post-operative patients with obstructive jaundice]. Hua Xi Yi Ke Da Xue Xue Bao 2001;32(4):587-589. 12528557
  43. Popovich, D. G. and Kitts, D. D. Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells. J Biochem Mol Toxicol 2004;18(3):143-149. 15252870
  44. Bhargava, H. N. and Ramarao, P. The effect of Panax ginseng on the development of tolerance to the pharmacological actions of morphine in the rat. Gen Pharmacol 1991;22(3):521-525. 1869026
  45. Zhao, L. M., Xiong, S. D., and Niu, R. J. [Effect of shenmai injection on L-type calcium channel of diaphragmatic muscle cells in rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2003;23(8):599-602. 14503060
  46. Li, N. S., Xiong, X. M., and Liu, L. Y. [Protective effects of shenmai injection on DPPH free radical-induced injuries in isolated hearts in rabbits]. Hunan Yi Ke Da Xue Xue Bao 2003;28(3):247-250. 14653080
  47. Rausch, W. D., Liu, S., Gille, G., and Radad, K. Neuroprotective effects of ginsenosides. Acta Neurobiol Exp (Wars) 2006;66(4):369-375. 17265697
  48. Takeda, A., Yonezawa, M., and Katoh, N. Restoration of radiation injury by ginseng. I. Responses of X- irradiated mice to ginseng extract. J Radiat Res (Tokyo) 1981;22(3):323-335. 7328517
  49. Beyer, I. and Rimpler, M. Ginseng: Adaptogenicity - Part I. Biological Therapy 1996;14 (3):202-220.
  50. Sun, W. S., Imai, A., Tagami, K., Sugiyama, M., Furui, T., and Tamaya, T. In vitro stimulation of granulosa cells by a combination of different active ingredients of unkei-to. Am J Chin Med 2004;32(4):569-578. 15481646
  51. Goel, D. P., Geiger, J. D., Shan, J. J., Kriellaars, D., and Pierce, G. N. Doping-control urinalysis of a ginseng extract, Cold-FX, in athletes. Int J Sport Nutr Exerc Metab 2004;14(4):473-480. 15467104
  52. Oliff, H. S. and Blumenthal, M. COLD-fX(r), Special Patented Extract of American Ginseng Root, Treats Cold Symptoms in Canadian Trial. HerbalGram 2006;(70):6.
  53. Hammond, T. G. and Whitworth, J. A. Adverse reactions to ginseng. Med J Aust 5-2-1981;1(9):492. 7254115
  54. Lee, D. C., Kim, C. Y., Lee, M. O., and Clifford, D. H. Effects of the second (ethanol) extract of ginseng on the cardiovascular dynamics of dogs during halothane anesthesia. Comp Med East West 1979;6(3):247-252. 157841
  55. Han, K. H., Choe, S. C., Kim, H. S., Sohn, D. W., Nam, K. Y., Oh, B. H., Lee, M. M., Park, Y. B., Choi, Y. S., Seo, J. D., and Lee, Y. W. Effect of red ginseng on blood pressure in patients with essential hypertension and white coat hypertension. Am J Chin Med 1998;26(2):199-209. 9799972
  56. Chen, X., Gillis, C. N., and Moalli, R. Vascular effects of ginsenosides in vitro. Br J Pharmacol 1984;82(2):485-491. 6587929
  57. Kaku, T., Miyata, T., Uruno, T., Sako, I., and Kinoshita, A. Chemico-pharmacological studies on saponins of Panax ginseng C. A. Meyer. II. Pharmacological part. Arzneimittelforschung 1975;25(4):539-547. 239732
  58. Wang, W. K., Chen, H. L., Hsu, T. L., and Wang, Y. Y. Alteration of pulse in human subjects by three Chinese herbs. Am J Chin Med 1994;22(2):197-203. 7992821
  59. Caron, M. F., Hotsko, A. L., Robertson, S., Mandybur, L., Kluger, J., and White, C. M. Electrocardiographic and hemodynamic effects of Panax ginseng. Ann Pharmacother 2002;36(5):758-763. 11978148
  60. Lee, D. C., Lee, M. O., Kim, C. Y., and Clifford, D. H. Effect of ether, ethanol and aqueous extracts of ginseng on cardiovascular function in dogs. Can J Comp Med 1981;45(2):182-187. 7260731
  61. Kim, H., Chen, X., and Gillis, C. N. Ginsenosides protect pulmonary vascular endothelium against free radical-induced injury. Biochem Biophys Res Commun 12-15-1992;189(2):670-676. 1472038
  62. Lei, X. L. and Chiou, G. C. Cardiovascular pharmacology of Panax notoginseng (Burk) F.H. Chen and Salvia miltiorrhiza. Am J Chin Med 1986;14(3-4):145-152. 3799531
  63. Chen, X. Cardiovascular protection by ginsenosides and their nitric oxide releasing action. Clin Exp Pharmacol Physiol 1996;23(8):728-732. 8886498
  64. Bae, E. A., Shin, J. E., and Kim, D. H. Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect. Biol Pharm Bull 2005;28(10):1903-1908. 16204943
  65. Gray, S. L., Lackey, B. R., Tate, P. L., Riley, M. B., and Camper, N. D. Mycotoxins in root extracts of American and Asian ginseng bind estrogen receptors alpha and beta. Exp Biol Med (Maywood) 2004;229(6):560-568. 15169976
  66. Polan, M. L., Hochberg, R. B., Trant, A. S., and Wuh, H. C. Estrogen bioassay of ginseng extract and ArginMax, a nutritional supplement for the enhancement of female sexual function. J Womens Health (Larchmt) 2004;13(4):427-430. 15186659
  67. Lee, Y., Jin, Y., Lim, W., Ji, S., Choi, S., Jang, S., and Lee, S. A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. J Steroid Biochem Mol Biol 2003;84(4):463-468. 12732291
  68. Forgo, I., Kayasseh, L., and Staub, J. J. [Effect of a standardized ginseng extract on general well-being, reaction time, lung function and gonadal hormones]. Med Welt 5-8-1981;32(19):751-756. 7231139
  69. Rotshteyn, Y. and Zito, S. W. Application of modified in vitro screening procedure for identifying herbals possessing sulfonylurea-like activity. J Ethnopharmacol 2004;93(2-3):337-344. 15234774
  70. Sievenpiper, J. L., Arnason, J. T., Leiter, L. A., and Vuksan, V. Null and opposing effects of Asian ginseng (Panax ginseng C.A. Meyer) on acute glycemia: results of two acute dose escalation studies. J Am Coll Nutr 2003;22(6):524-532. 14684758
  71. Chavez M. Treatment of Diabetes Mellitus with ginseng. J Herb Pharmacol 2001;1(2):99-113.
  72. Vuksan V, Xu Z, Sievenpiper J, and et al. American ginseng improves plasminogen activator inhibitor concentrations in type 2 diabetes. Diabetes 2001;50:A368.
  73. Cheng, T. O. Panax (ginseng) is not a panacea. Arch Intern.Med 11-27-2000;160(21):3329-1. 11088100
  74. Vuksan, V., Stavro, M. P., Sievenpiper, J. L., Koo, V. Y., Wong, E., Beljan-Zdravkovic, U., Francis, T., Jenkins, A. L., Leiter, L. A., Josse, R. G., and Xu, Z. American ginseng improves glycemia in individuals with normal glucose tolerance: effect of dose and time escalation. J Am Coll Nutr 2000;19(6):738-744. 11194526
  75. Vuksan, V., Sievenpiper, J. L., Koo, V. Y., Francis, T., Beljan-Zdravkovic, U., Xu, Z., and Vidgen, E. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 4-10-2000;160(7):1009-1013. 10761967
  76. Sotaniemi, E. A., Haapakoski, E., and Rautio, A. Ginseng therapy in non-insulin-dependent diabetic patients. Diabetes Care 1995;18(10):1373-1375. 8721940
  77. Suzuki Y and Hikino H. Mechanisms of hypoglycemic activity of panaxans a and B, glycans of Panax ginseng roots: effects of the key enzymes of glucose metabolism in the liver of mice. Phytotherapy Research 1989;3(1):15-24.
  78. Ng, T. B. and Yeung, H. W. Hypoglycemic constituents of Panax ginseng. Gen Pharmacol 1985;16(6):549-552. 3910515
  79. Martinez, B. and Staba, E. J. The physiological effects of Aralia, Panax and Eleutherococcus on exercised rats. Jpn J Pharmacol 1984;35(2):79-85. 6379247
  80. Bol'shakova, I. V., Lozovskaia, E. L., and Sapezhinskii, I. I. [Photosensitizing and photoprotective properties of extracts from groups of medicinal plants]. Biofizika 1997;42(4):926-932. 9410021
  81. Jiangming L, Haiwei C, Aisheng W, and et al. Comparative study effect of Panax notoginseng and Ticlid in treating early diabetes nephropathy [abstract]. Diabetes 2000;49:A376.
  82. White MC, Fan C, and Chow M. An evaluation of the hemostatic effect of externally applied notoginseng and notoginseng total saponins. J Clin Pharmacol 2000;40:1150-1153.
  83. Yuan, C. S., Attele, A. S., Wu, J. A., Lowell, T. K., Gu, Z., and Lin, Y. Panax quinquefolium L. inhibits thrombin-induced endothelin release in vitro. Am J Chin Med 1999;27(3-4):331-338. 10592841
  84. Jung, K. Y., Kim, D. S., Oh, S. R., Lee, I. S., Lee, J. J., Park, J. D., Kim, S. I., and Lee, H. K. Platelet activating factor antagonist activity of ginsenosides. Biol Pharm Bull 1998;21(1):79-80. 9477174
  85. Zhang, W. J., Wojta, J., and Binder, B. R. Effect of notoginsenoside R1 on the synthesis of components of the fibrinolytic system in cultured smooth muscle cells of human pulmonary artery. Cell Mol.Biol (Noisy.-le-grand) 1997;43(4):581-587. 9220151
  86. Park, H. J., Lee, J. H., Song, Y. B., and Park, K. H. Effects of dietary supplementation of lipophilic fraction from Panax ginseng on cGMP and cAMP in rat platelets and on blood coagulation. Biol Pharm Bull 1996;19(11):1434-1439. 8951159
  87. Park, H. J., Rhee, M. H., Park, K. M., Nam, K. Y., and Park, K. H. Effect of non-saponin fraction from Panax ginseng on cGMP and thromboxane A2 in human platelet aggregation. J Ethnopharmacol 12-15-1995;49(3):157-162. 8824741
  88. Kuo, S. C., Teng, C. M., Lee, J. C., Ko, F. N., Chen, S. C., and Wu, T. S. Antiplatelet components in Panax ginseng. Planta Med 1990;56(2):164-167. 2353062
  89. Teng, C. M., Kuo, S. C., Ko, F. N., Lee, J. C., Lee, L. G., Chen, S. C., and Huang, T. F. Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. Biochim Biophys Acta 3-24-1989;990(3):315-320. 2923911
  90. Matsuda, H., Namba, K., Fukuda, S., Tani, T., and Kubo, M. Pharmacological study on Panax ginseng C. A. Meyer. III. Effects of red ginseng on experimental disseminated intravascular coagulation. (2). Effects of ginsenosides on blood coagulative and fibrinolytic systems. Chem Pharm Bull (Tokyo) 1986;34(3):1153-1157. 3731336
  91. Yamamoto, M., Uemura, T., Nakama, S., Uemiya, M., and Kumagai, A. Serum HDL-cholesterol-increasing and fatty liver-improving actions of Panax ginseng in high cholesterol diet-fed rats with clinical effect on hyperlipidemia in man. Am J Chin Med 1983;11(1-4):96-101. 6660221
  92. Wang, M., Guilbert, L. J., Ling, L., Li, J., Wu, Y., Xu, S., Pang, P., and Shan, J. J. Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium). J Pharm Pharmacol 2001;53(11):1515-1523. 11732754
  93. Reay, J. L., Kennedy, D. O., and Scholey, A. B. Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks. J Psychopharmacol 2006;20(6):771-781. 16401645
  94. Reay, J. L., Kennedy, D. O., and Scholey, A. B. The glycaemic effects of single doses of Panax ginseng in young healthy volunteers. Br J Nutr 2006;96(4):639-642. 17010221
  95. Stavro, P. M., Woo, M., Leiter, L. A., Heim, T. F., Sievenpiper, J. L., and Vuksan, V. Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function. Hypertension 2006;47(4):791-796. 16520410
  96. Scaglione, F., Ferrara, F., Dugnani, S., Falchi, M., Santoro, G., and Fraschini, F. Immunomodulatory effects of two extracts of Panax ginseng C.A. Meyer. Drugs Exp Clin Res 1990;16(10):537-542. 2100737
  97. Li, P., Wang, H., Gao, J., Tong, A., Wu, B., and Yu, L. Needling Neiguan (P 6) for treatment of low pulse pressure syndrome--a report of 31 cases. J Tradit Chin Med 2005;25(4):273-275. 16447669
  98. Tode, T., Kikuchi, Y., Kita, T., Hirata, J., Imaizumi, E., and Nagata, I. Inhibitory effects by oral administration of ginsenoside Rh2 on the growth of human ovarian cancer cells in nude mice. J Cancer Res Clin Oncol 1993;120(1-2):24-26. 8270603
  99. Nabata, H., Saito, H., and Takagi, K. Pharmacological studies of neutral saponins (GNS) of Panax Ginseng root. Jpn J Pharmacol 1973;23(1):29-41. 4541616
  100. McElhaney, J. E. and et al. COLD-fX stimulates cell mediated immune response of peripheral leukocytes to influenza virus in National Hockey League players. Manuscript in preparation 2005;
  101. Davydov, V. V., Molokovskii, D. S., and Limarenko, A. I. [Efficacy of ginseng drugs in experimental insulin-dependent diabetes and toxic hepatitis]. Patol Fiziol Eksp Ter 1990;(5):49-52. 2293165
  102. Park, E. K., Choo, M. K., Kim, E. J., Han, M. J., and Kim, D. H. Antiallergic activity of ginsenoside Rh2. Biol Pharm Bull 2003;26(11):1581-1584. 14600405
  103. Anderson, G. D., Rosito, G., Mohustsy, M. A., and Elmer, G. W. Drug interaction potential of soy extract and Panax ginseng. J Clin Pharmacol 2003;43(6):643-648. 12817527
  104. Kim, H. C., Shin, E. J., Jang, C. G., Lee, M. K., Eun, J. S., Hong, J. T., and Oh, K. W. Pharmacological action of Panax ginseng on the behavioral toxicities induced by psychotropic agents. Arch Pharm Res 2005;28(9):995-1001. 16212227
  105. Lee, S. H., Ahn, Y. M., Ahn, S. Y., Doo, H. K., and Lee, B. C. Interaction between warfarin and Panax ginseng in ischemic stroke patients. J Altern Complement Med 2008;14(6):715-721. 18637764
  106. Choi, H. K., Seong, D. H., and Rha, K. H. Clinical efficacy of Korean red ginseng for erectile dysfunction. Int J Impot Res 1995;7(3):181-186. 8750052
  107. Mkrtchyan, A., Panosyan, V., Panossian, A., Wikman, G., and Wagner, H. A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects. Phytomedicine 2005;12(6-7):403-409. 16008115
  108. Salvati, G., Genovesi, G., Marcellini, L., Paolini, P., De, Nuccio, I, Pepe, M., and Re, M. Effects of Panax Ginseng C.A. Meyer saponins on male fertility. Panminerva Med 1996;38(4):249-254. 9063034
  109. Kim, O. S., Choi, J. H., Soung, Y. H., Lee, S. H., Lee, J. H., Ha, J. M., Ha, B. J., Heo, M. S., and Lee, S. H. Establishment of in vitro test system for the evaluation of the estrogenic activities of natural products. Arch Pharm Res 2004;27(9):906-911. 15473658
  110. Persson, I. A., Dong, L., and Persson, K. Effect of Panax ginseng extract (G115) on angiotensin-converting enzyme (ACE) activity and nitric oxide (NO) production. J Ethnopharmacol 5-24-2006;105(3):321-325. 16387458
  111. Lee, F. C., Ko, J. H., Park, J. K., and Lee, J. S. Effects of Panax ginseng on blood alcohol clearance in man. Clin Exp Pharmacol Physiol 1987;14(6):543-546. 3677487
  112. Sievenpiper, J. L., Arnason, J. T., Leiter, L. A., and Vuksan, V. Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia. Eur J Clin Nutr 2003;57(2):243-248. 12571655
  113. Stavro, P. M., Woo, M., Heim, T. F., Leiter, L. A., and Vuksan, V. North American ginseng exerts a neutral effect on blood pressure in individuals with hypertension. Hypertension 2005;46(2):406-411. 15998708
  114. Yi, R. L., Li, W., and Hao, X. Z. [Inductive differentiation effect of ginsenosides on human acute non- lymphocytic leukemic cells in 58 patients]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13(12):722-4, 708. 8136644
  115. Takahashi, M. and Tokuyama, S. Pharmacological and physiological effects of ginseng on actions induced by opioids and psychostimulants. Methods Find.Exp Clin Pharmacol 1998;20(1):77-84. 9575486
  116. Kim, H. S., Kim, K. S., and Oh, K. W. Inhibition by ginsenosides Rb1 and Rg1 of cocaine-induced hyperactivity, conditioned place preference, and postsynaptic dopamine receptor supersensitivity in mice. Pharmacol Biochem Behav 1999;63(3):407-412. 10418781
  117. Yang, L. and Liu, Y. Intestinal bacterial metabolite of naturally occurring 20(S)-protopanaxatriol ginsenosides is the inhibitor of CYP3A: A new biotransformation way with potential for clinical drug-drug interaction. Journal of the Pharmaceutical Society of Japan 2004;124:57-60.
  118. Ueng, Y. and et al. Effects of CVT-E002, a proprietary extract from North American ginseng (Panax qinquefolium) on Hepatic Drug-Metabolizing Enzymes in C57BL/6J Mice. Journal of Chinese Medicine 2002;13(2):89-96.
  119. Holt, A. and Shan, J. Inhibition of human hepatic cytochrome P450 enzymes by COLD-Fx and REMEMBER-Fx - proprietary extracts of North American ginseng (Panax quinquefolium). Journal of Complementary and Integrative Medicine 2005;2(1):28.
  120. Liu, D., Li, B., Liu, Y., Attele, A. S., Kyle, J. W., and Yuan, C. S. Voltage-dependent inhibition of brain Na(+) channels by American ginseng. Eur J Pharmacol 2-9-2001;413(1):47-54. 11173062
  121. Chong, S. K., Brown, H. A., Rimmer, E., Oberholzer, V., Hindocha, P., and Walker-Smith, J. A. In vitro effect of Panax ginseng on phytohaemagglutinin-induced lymphocyte transformation. Int Arch Allergy Appl Immunol 1984;73(3):216-220. 6698617
  122. Li, J. P., Huang, M., Teoh, H., and Man, R. Y. Interactions between Panax quinquefolium saponins and vitamin C are observed in vitro. Mol Cell Biochem 2000;204(1-2):77-82. 10718627
  123. Fulder, S. J. Ginseng and the hypothalamic-pituitary control of stress. Am J Chin Med 1981;9(2):112-118. 7345916
  124. Fahim, M. S., Fahim, Z., Harman, J. M., Clevenger, T. E., Mullins, W., and Hafez, E. S. Effect of Panax ginseng on testosterone level and prostate in male rats. Arch Androl 1982;8(4):261-263. 7202345
  125. Attele, A. S., Wu, J. A., and Yuan, C. S. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 12-1-1999;58(11):1685-1693. 10571242
  126. Ang-Lee, M. K., Moss, J., and Yuan, C. S. Herbal medicines and perioperative care. JAMA 7-11-2001;286(2):208-216. 11448284
  127. Anonymous. "High" tea. The Medical Journal of Australia 1979;2(5):232.
  128. Lee, B. H., Jeong, S. M., Lee, J. H., Kim, D. H., Kim, J. H., Kim, J. I., Shin, H. C., Lee, S. M., and Nah, S. Y. Differential effect of ginsenoside metabolites on the 5-HT3A receptor-mediated ion current in Xenopus oocytes. Mol Cells 2-29-2004;17(1):51-56. 15055527
  129. Choi, H. H., Jong, H. S., Park, J. H., Choi, S., Lee, J. W., Kim, T. Y., Otsuki, T., Namba, M., and Bang, Y. J. A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells. Int J Oncol 2003;23(4):1087-1093. 12963989
  130. Chong SFK and Oberholzer VG. Ginseng-is there a use in clinical medicine? Postgraduate Medical Journal 1988;64:841-846.
  131. Chuang WC, Wu HK, Sheu SJ, and et al. A comparative study on commercial samples of Ginseng radix. Planta Med 1995;61:459-465.
  132. Vaughan MA, Doolittle RL, Gennett T, and et al. Physiological effects of ginseng may be due to methylxanthines. Medicine and Science in Sports and Exercise 1999;31:S121.
  133. Cho, J. Y., Yoo, E. S., Baik, K. U., Park, M. H., and Han, B. H. In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists. Planta Med 2001;67(3):213-218. 11345690
  134. Dou, D. Q., Zhang, Y. W., Zhang, L., Chen, Y. J., and Yao, X. S. The inhibitory effects of ginsenosides on protein tyrosine kinase activated by hypoxia/reoxygenation in cultured human umbilical vein endothelial cells. Planta Med 2001;67(1):19-23. 11270715
  135. Kim, S. E., Lee, Y. H., Park, J. H., and Lee, S. K. Ginsenoside-Rs4, a new type of ginseng saponin concurrently induces apoptosis and selectively elevates protein levels of p53 and p21WAF1 in human hepatoma SK-HEP-1 cells. Eur J Cancer 1999;35(3):507-511. 10448308
  136. Matsunaga, H., Saita, T., Nagumo, F., Mori, M., and Katano, M. [Relationship between antiproliferative activity of acetylenic alcohol, panaxydol, and its affinity for target cell membrane]. Gan To Kagaku Ryoho 1994;21(15):2585-2589. 7979417
  137. Tomoda, M., Hirabayashi, K., Shimizu, N., Gonda, R., and Ohara, N. The core structure of ginsenan PA, a phagocytosis-activating polysaccharide from the root of Panax ginseng. Biol Pharm Bull 1994;17(9):1287-1291. 7841955
  138. Heck, A. M., DeWitt, B. A., and Lukes, A. L. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 7-1-2000;57(13):1221-1227. 10902065
  139. Glockl, I., Veit, M., and Blaschke, G. Determination of Ginsenosides from Panax ginseng using Micellar Electrokinetic Chromatography. Planta Med 2002;68(2):158-161. 11859468
  140. Awang, D. V. C. The neglected ginsenosides of north American ginseng (panax quinquefolius L). J Herbs, Spices, and Medicinal Plants 2000;7(2):103-109.
  141. Reynolds, B. L. Effects of drying on chemical and physical characteristics of American ginseng (panax quinquefolius L). J Herbs, Spices, and Medicinal Plants 1998;6(2):9-21.
  142. Nah, J. J., Hahn, J. H., Chung, S., Choi, S., Kim, Y. I., and Nah, S. Y. Effect of ginsenosides, active components of ginseng, on capsaicin-induced pain-related behavior. Neuropharmacology 8-23-2000;39(11):2180-2184. 10963761
  143. Liang, H. C., Chen, C. T., Chang, Y., Huang, Y. C., Chen, S. C., and Sung, H. W. Loading of a novel angiogenic agent, ginsenoside Rg1 in an acellular biological tissue for tissue regeneration. Tissue Eng 2005;11(5-6):835-846. 15998223
  144. Fan, Y. G. and Zhao, C. Q. [Effects of Shengmai Chenggu capsule on proliferation and vascular endothelial growth factor secretion of vascular endothelial cells]. Di Yi Jun.Yi Da Xue Xue Bao 2005;25(10):1228-1231. 16234095
  145. Metori, K., Furutsu, M., and Takahashi, S. The preventive effect of ginseng with du-zhong leaf on protein metabolism in aging. Biol Pharm Bull 1997;20(3):237-242. 9084879
  146. Lee, K. D. and Huemer, R. P. Antitumoral activity of Panax ginseng extracts. Jpn.J Pharmacol 1971;21(3):299-302. 5314720
  147. Xiaoguang, C., Hongyan, L., Xiaohong, L., Zhaodi, F., Yan, L., Lihua, T., and Rui, H. Cancer chemopreventive and therapeutic activities of red ginseng. J Ethnopharmacol. 1998;60(1):71-78. 9533434
  148. Rui, H. Research and development of cancer chemopreventive agents in China. J Cell Biochem Suppl 1997;27:7-11. 9591187
  149. Katano, M., Yamamoto, H., Matsunaga, H., Mori, M., Takata, K., and Nakamura, M. [Cell growth inhibitory substance isolated from Panax ginseng root: panaxytriol]. Gan To Kagaku Ryoho 1990;17(5):1045-1049. 2334170
  150. Katano, M., Matsunaga, H., and Yamamoto, H. [A tumor inhibitory substance from panax ginseng]. Nippon Geka Gakkai Zasshi 1988;89(6):971. 3185481
  151. Katano, M., Yamamoto, H., and Hisatsugu, T. [Tumor growth inhibition by water-soluble substance from Panax ginseng]. Nippon Geka Gakkai Zasshi 1987;88(12):1754. 3447041
  152. Odashima, S., Ota, T., Fujikawa-Yamamoto, K., and Abe, H. [Induction of phenotypic reverse transformation by plant glycosides in cultured cancer cells]. Gan To Kagaku Ryoho 1989;16(4 Pt 2-2):1483-1489. 2658830
  153. Zhang, Y. W., Dou, D. Q., Chen, Y. J., and Yao, X. S. Effect of ginsenosides from Panax ginseng on proliferation of human osteosarcoma cell U\IF/2\BS/OS. Chin Tradit Herb Drugs 2001;32:232-236.
  154. Ma, S. G., Jiang, Y. T., Song, S. J., Wang, Z. H., Bai, J., Xu, S. X., and Liu, K. [Alkaline-degradation products of ginsenosides from leaves and stems of Panax quinquefolium]. Yao Xue Xue Bao 2005;40(10):924-930. 16408811
  155. Nakata, H., Kikuchi, Y., Tode, T., Hirata, J., Kita, T., Ishii, K., Kudoh, K., Nagata, I., and Shinomiya, N. Inhibitory effects of ginsenoside Rh2 on tumor growth in nude mice bearing human ovarian cancer cells. Jpn J Cancer Res 1998;89(7):733-740. 9738980
  156. Yun, T. K., Lee, Y. S., Lee, Y. H., Kim, S. I., and Yun, H. Y. Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds. J Korean Med Sci 2001;16 Suppl:S6-18. 11748383
  157. Yun, T. K. and Choi, S. Y. Preventive effect of ginseng intake against various human cancers: a case-control study on 1987 pairs. Cancer Epidemiol Biomarkers Prev 1995;4(4):401-408. 7655337
  158. Shin, H. R., Kim, J. Y., Yun, T. K., Morgan, G., and Vainio, H. The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence. Cancer Causes Control 2000;11(6):565-576. 10880039
  159. Yun, T. K. and Choi, S. Y. Non-organ specific cancer prevention of ginseng: a prospective study in Korea. Int J Epidemiol 1998;27(3):359-364. 9698120
  160. Yun, T. K., Choi, S. Y., and Yun, H. Y. Epidemiological study on cancer prevention by ginseng: are all kinds of cancers preventable by ginseng? J Korean Med Sci 2001;16 Suppl:S19-S27. 11748373
  161. Sonnenborn U. Ginseng- neuere Untersuchungen immunologischer, pharmakologischer und endokrinologischer Aktivitat einer alten Arzneipflanze. Dtsch Apoth Ztg 1987;127:433-441.
  162. Yun, T. K. Experimental and epidemiological evidence of the cancer-preventive effects of Panax ginseng C.A. Meyer. Nutr Rev 1996;54(11 Pt 2):S71-S81. 9110579
  163. Yun, Y. S., Lee, Y. S., Jo, S. K., and Jung, I. S. Inhibition of autochthonous tumor by ethanol insoluble fraction from Panax ginseng as an immunomodulator. Planta Med 1993;59(6):521-524. 8302951
  164. Corbit, R., Ebbs, S., King, M. L., and Murphy, L. L. The influence of lead and arsenite on the inhibition of human breast cancer MCF-7 cell proliferation by American ginseng root (Panax quinquefolius L.). Life Sci 2-16-2006;78(12):1336-1340. 16288926
  165. Wakabayashi, C., Hasegawa, H., Murata, J., and Saiki, I. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol Res 1997;9(8):411-417. 9436194
  166. Duda, R. B., Zhong, Y., Navas, V., Li, M. Z., Toy, B. R., and Alavarez, J. G. American ginseng and breast cancer therapeutic agents synergistically inhibit MCF-7 breast cancer cell growth. J Surg Oncol 1999;72(4):230-239. 10589039
  167. Lyubimov II, Chepurnov SA, and Chepurnova NE. Recombinant human cytokines and polysaccharides from ginseng: The combine effects on the behavior and antitumor action. Journal of Neurochemistry 1997;69(Suppl 1):s252.
  168. Hosono-Nishiyama, K., Matsumoto, T., Kiyohara, H., Nishizawa, A., Atsumi, T., and Yamada, H. Suppression of Fas-mediated apoptosis of keratinocyte cells by chikusetsusaponins isolated from the roots of Panax japonicus. Planta Med 2006;72(3):193-198. 16534721
  169. Chen, Z., Wang, P., Huang, W. X., and Liu, L. M. [Experimental study on effects of shengmai injection: enhancing 5-FU anti-tumor efficacy and reducing its toxicity]. Zhong Xi Yi Jie He Xue Bao 2005;3(6):476-479. 16282061
  170. Feng, P. F., Liu, L. M., and Shen, Y. Y. [Effect of shenmai injection on sIL-2R NK and LAK cells in patients with advanced carcinoma]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1995;15(2):87-89. 7787398
  171. Hofseth, L. J. and Wargovich, M. J. Inflammation, cancer, and targets of ginseng. J Nutr 2007;137(1 Suppl):183S-185S. 17182823
  172. Cabral de Oliveira, A. C., Perez, A. C., Merino, G., Prieto, J. G., and Alvarez, A. I. Protective effects of Panax ginseng on muscle injury and inflammation after eccentric exercise. Comp Biochem Physiol C Toxicol Pharmacol 2001;130(3):369-377. 11701393
  173. Wang, R., Gao, C., and Liu, D. Effects of shenmai injection on expression of TNF-alpha mRNA in peritoneal macrophages of scald mice. Chin Med J (Engl) 2002;115(2):293-295. 11940352
  174. Ahn, J. Y., Song, J. Y., Yun, Y. S., Jeong, G., and Choi, I. S. Protection of Staphylococcus aureus-infected septic mice by suppression of early acute inflammation and enhanced antimicrobial activity by ginsan. FEMS Immunol.Med Microbiol 2006;46(2):187-197. 16487300
  175. Akagawa, G., Abe, S., Tansho, S., Uchida, K., and Yamaguchi, H. Protection of C3H/HE J mice from development of Candida albicans infection by oral administration of Juzen-taiho-to and its component, Ginseng radix: possible roles of macrophages in the host defense mechanisms. Immunopharmacol Immunotoxicol 1996;18(1):73-89. 8683040
  176. Belogortseva, N. I., Yoon, J. Y., and Kim, K. H. Inhibition of Helicobacter pylori hemagglutination by polysaccharide fractions from roots of Panax ginseng. Planta Med 2000;66(3):217-220. 10821045
  177. Feng, L. M., Pan, H. Z., and Li, W. W. [Anti-oxidant action of Panax ginseng]. Zhong Xi Yi Jie He Za Zhi 1987;7(5):288-90, 262. 3690748
  178. Chang, M. S., Lee, S. G., and Rho, H. M. Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng. Phytother Res 1999;13(8):641-644. 10594930
  179. Li, J., Huang, M., Teoh, H., and Man, R. Y. Panax quinquefolium saponins protects low density lipoproteins from oxidation. Life Sci 1999;64(1):53-62. 10027742
  180. Siddique, M. S., Eddeb, F., Mantle, D., and Mendelow, A. D. Extracts of Ginkgo biloba and Panax ginseng protect brain proteins from free radical induced oxidative damage in vitro. Acta Neurochir Suppl 2000;76:87-90. 11450098
  181. Niwa, Y. and Miyachi, Y. Antioxidant action of natural health products and Chinese herbs. Inflammation 1986;10(1):79-91. 3007357
  182. Wang, L., Nishida, H., Ogawa, Y., and Konishi, T. Prevention of oxidative injury in PC12 cells by a traditional Chinese medicine, Shengmai San, as a model of an antioxidant-based composite formula. Biol Pharm Bull 2003;26(7):1000-1004. 12843626
  183. Lee, B. M., Lee, S. K., and Kim, H. S. Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, beta-carotene and red ginseng). Cancer Lett 10-23-1998;132(1-2):219-227. 10397477
  184. Jiang, X., Williams, K. M., Liauw, W. S., Ammit, A. J., Roufogalis, B. D., Duke, C. C., Day, R. O., and McLachlan, A. J. Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol 2004;57(5):592-599. 15089812
  185. Sun, X. B., Matsumoto, T., and Yamada, H. Anti-ulcer activity and mode of action of the polysaccharide fraction from the leaves of Panax ginseng. Planta Med 1992;58(5):432-435. 1470667
  186. Suzuki, Y., Ito, Y., Konno, C., and Furuya, T. [Effects of tissue cultured ginseng on gastric secretion and pepsin activity]. Yakugaku Zasshi 1991;111(12):770-774. 1806658
  187. Singh, V. K., George, C. X., Singh, N., Agarwal, S. S., and Gupta, B. M. Combined treatment of mice with Panax ginseng extract and interferon inducer. Amplification of host resistance to Semliki forest virus. Planta Med 1983;47(4):234-236. 6306707
  188. Yuan, J., Guo, W., Yang, B., Liu, P., Wang, Q., and Yuan, H. 116 cases of coronary angina pectoris treated with powder composed of radix ginseng, radix notoginseng and succinum. J Tradit Chin Med 1997;17(1):14-17. 10437237
  189. Kwan, C. Y. Vascular effects of selected antihypertensive drugs derived from traditional medicinal herbs. Clin Exp Pharmacol Physiol 1995;22 Suppl 1:S297-S299. 8785815
  190. Feng, P. F., Qin, N. P., and Qiao, Q. [Clinical and experimental study of improving left ventricular diastolic function by total saponins of panax notoginseng]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1997;17(12):714-717. 10322816
  191. Liao, J. Z., Chen, J. J., Wu, Z. M., Guo, W. Q., Zhao, L. Y., Qin, L. M., Wang, S. R., and Zhao, Y. R. Clinical and experimental studies of coronary heart disease treated with yi-qi huo-xue injection. J Tradit Chin Med 1989;9(3):193-198. 2615456
  192. Lin, S. G., Zheng, X. L., Chen, Q. Y., and Sun, J. J. Effect of Panax notoginseng saponins on increased proliferation of cultured aortic smooth muscle cells stimulated by hypercholesterolemic serum. Zhongguo Yao Li Xue Bao 1993;14(4):314-316. 8249623
  193. Toh, H. T. Improved isolated heart contractility and mitochondrial oxidation after chronic treatment with Panax ginseng in rats. Am J Chin Med 1994;22(3-4):275-284. 7872239
  194. Xiong, Z. G. and Sun, J. J. [Effects of Panax notoginseng saponin Rb1 and Rg1 on myocardial action potential and slow inward current]. Zhongguo Yao Li Xue Bao 1989;10(6):520-522. 2641849
  195. Li, X., Guo, R., and Li, L. [Pharmacological variations of Panax ginseng C.A. Meyer during processing]. Zhongguo Zhong Yao Za Zhi 1991;16(1):3-7, 62. 2069699
  196. Hong, Y., Xie, W., and Chen, C. S. [Effect of shengmai injection on TRAIL death receptor of patients with congestive heart failure]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2005;25(12):1092-1095. 16398429
  197. Liao, J. and et al. Effect of Shengmai San on left ventricular performance in coronary heart disease. Journal of Traditional Chinese Medicine 1982;2(1):57-62.
  198. Liu, Z. Observation on effect of shenmai injection in treating patients of congestive heart failure. Chinese Journal of Integrated Traditional and Western Medicine 2000;6(2):119-121.
  199. Bai, C. X., Takahashi, K., Masumiya, H., Sawanobori, T., and Furukawa, T. Nitric oxide-dependent modulation of the delayed rectifier K+ current and the L-type Ca2+ current by ginsenoside Re, an ingredient of Panax ginseng, in guinea-pig cardiomyocytes. Br J Pharmacol 2004;142(3):567-575. 15148247
  200. Ohtani, K., Mizutani, K., Hatono, S., Kasai, R., Sumino, R., Shiota, T., Ushijima, M., Zhou, J., Fuwa, T., and Tanaka, O. Sanchinan-A, a reticuloendothelial system activating arabinogalactan from sanchi-ginseng (roots of Panax notoginseng). Planta Med 1987;53(2):166-169. 3602143
  201. Kim, Y. S., Kim, D. S., and Kim, S. I. Ginsenoside Rh2 and Rh3 induce differentiation of HL-60 cells into granulocytes: modulation of protein kinase C isoforms during differentiation by ginsenoside Rh2. Int J Biochem Cell Biol 1998;30(3):327-338. 9611775
  202. Qureshi, A. A., Abuirmeileh, N., Din, Z. Z., Ahmad, Y., Burger, W. C., and Elson, C. E. Suppression of cholesterogenesis and reduction of LDL cholesterol by dietary ginseng and its fractions in chicken liver. Atherosclerosis 1983;48(1):81-94. 6882511
  203. Sakakibara, K., Shibata, Y., Higashi, T., Sanada, S., and Shoji, J. Effect of ginseng saponins on cholesterol metabolism. I. The level and the synthesis of serum and liver cholesterol in rats treated with ginsenosides. Chem Pharm Bull (Tokyo) 1975;23(5):1009-1016. 1181066
  204. Pan SJ, Ding Z, and Ivy JL. Effects of six weeks of panax ginseng on triglycerides and MRNA profiles in an animal model of type II diabetes [abstract]. International Scientific Conference on Complementary, Alternative and Integrative Medicine Research, April 12-14 2002;
  205. Kwon, B. M., Nam, J. Y., Lee, S. H., Jeong, T. S., Kim, Y. K., and Bok, S. H. Isolation of cholesteryl ester transfer protein inhibitors from Panax ginseng roots. Chem Pharm Bull (Tokyo) 1996;44(2):444-445. 8998846
  206. Yang, F., Zheng, Y., Li, D., and Deng, W. [Effect of shenfu injection on microcirculation]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2003;20(1):91-4, 100. 12744172
  207. Takagi, K., Saito, H., and Nabata, H. Pharmacological studies of Panax ginseng root: estimation of pharmacological actions of Panax ginseng root. Jpn J Pharmacol 1972;22(2):245-249. 4538416
  208. Lee, T, Shiao, Y. J., Chen, C. F., and Wang, L. C. Effect of Ginseng Saponins on beta-Amyloid-Suppressed Acetylcholine Release from Rat Hippocampal Slices. Planta Med 2001;67(7):634-637. 11582541
  209. Rudakewich, M., Ba, F., and Benishin, C. G. Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1). Planta Med 2001;67(6):533-537. 11509974
  210. Nitta, H., Matsumoto, K., Shimizu, M., Ni, X. H., and Watanabe, H. Panax ginseng extract improves the scopolamine-induced disruption of 8- arm radial maze performance in rats. Biol Pharm Bull 1995;18(10):1439-1442. 8593452
  211. Sloley, B. D., Pang, P. K., Huang, B. H., and et al. American ginseng extract reduces scopolamine-induced amnesia in a spatial learning task. J Psychiatry Neurosci 1999;24(5):442-452. 10586535
  212. Bhattacharya, S. K. and Mitra, S. K. Anxiolytic activity of Panax ginseng roots: an experimental study. J Ethnopharmacol 1991;34(1):87-92. 1684404
  213. Ramarao, P. and Bhargava, H. N. Antagonism of the acute pharmacological actions of morphine by panax ginseng extract. Gen Pharmacol 1990;21(6):877-880. 2279687
  214. Itoh, T., Zang, Y. F., Murai, S., and Saito, H. Effects of Panax ginseng root on the vertical and horizontal motor activities and on brain monoamine-related substances in mice. Planta Med 1989;55(5):429-433. 2813579
  215. Tsang, D., Yeung, H. W., Tso, W. W., and Peck, H. Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes. Planta Med 1985;(3):221-224. 2863834
  216. Choi, S. E., Choi, S., Lee, J. H., Whiting, P. J., Lee, S. M., and Nah, S. Y. Effects of ginsenosides on GABA(A) receptor channels expressed in Xenopus oocytes. Arch Pharm Res 2003;26(1):28-33. 12568354
  217. Shim I, Kim Y, Kim S, and et al. Effect of ginseng total saponin on nicotine-induced dopamine release in the rat nucleus accumbens and striatum. Journal of Neurochemistry 1998;70(Suppl 2):S30.
  218. Attele, A. S., Xie, J. T., and Yuan, C. S. Treatment of insomnia: an alternative approach. Altern Med Rev 2000;5(3):249-259. 10869104
  219. Dimpfel, W., Kler, A., Kriesl, E., Lehnfeld, R., and Keplinger-Dimpfel, I. K. Neurophysiological characterization of a functionally active drink containing extracts of ginkgo and ginseng by source density analysis of the human EEG. Nutr Neurosci 2006;9(5-6):213-224. 17263088
  220. Lee, J. Y., Kim, J. W., Cho, S. D., Kim, Y. H., Choi, K. J., Joo, W. H., Cho, Y. K., and Moon, J. Y. Protective effect of ginseng extract against apoptotic cell death induced by 2,2',5,5'-tetrachlorobiphenyl in neuronal SK-N-MC cells. Life Sci 8-13-2004;75(13):1621-1634. 15261766
  221. Wang, N. L., Liou, Y. L., Lin, M. T., Lin, C. L., and Chang, C. K. Chinese herbal medicine, Shengmai San, is effective for improving circulatory shock and oxidative damage in the brain during heatstroke. J Pharmacol Sci 2005;97(2):253-265. 15699577
  222. Wang, N. L., Chang, C. K., Liou, Y. L., Lin, C. L., and Lin, M. T. Shengmai San, a Chinese herbal medicine protects against rat heat stroke by reducing inflammatory cytokines and nitric oxide formation. J Pharmacol Sci 2005;98(1):1-7. 15879682
  223. He, Z. Y., Lu, X. F., and Qu, B. [Protective effects of shenmai injection on the delayed injury of the cerebral neurons in rat induced by intracerebral hemorrhage]. Zhongguo Zhong Yao Za Zhi 2005;30(7):526-530. 16011100
  224. He, L. Y., Sun, S. L., and Fan, J. P. [Effect of shenmai injection on neurocyte apoptosis and change of cytoplasmic calcium]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2001;21(8):605-607. 12575577
  225. Samira, M. M., Attia, M. A., Allam, M., and Elwan, O. Effect of the standardized Ginseng Extract G115 on the metabolism and electrical activity of the rabbit's brain. J Int Med Res 1985;13(6):342-348. 4076533
  226. Sun, X. B., Matsumoto, T., Kiyohara, H., Hirano, M., and Yamada, H. Cytoprotective activity of pectic polysaccharides from the root of panax ginseng. J Ethnopharmacol 1991;31(1):101-107. 2030589
  227. Ahn, B. Z. and Kim, S. I. [Heptadeca-1, 8t-dien-4, 6-diyne-3, 10-diol, a substance cytotoxic to L1210 cells from Korean ginseng roots]. Planta Med 1988;54(2):183. 3406174
  228. Matsunaga, H., Saita, T., Nagumo, F., Mori, M., and Katano, M. A possible mechanism for the cytotoxicity of a polyacetylenic alcohol, panaxytriol: inhibition of mitochondrial respiration. Cancer Chemother Pharmacol 1995;35(4):291-296. 7828271
  229. See, D. M., Broumand, N., Sahl, L., and Tilles, J. G. In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacology 1997;35(3):229-235. 9043936
  230. Gurley, B. J., Gardner, S. F., Hubbard, M. A., Williams, D. K., Gentry, W. B., Cui, Y., and Ang, C. Y. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clin Pharmacol Ther 2002;72(3):276-287. 12235448
  231. Kanzaki, T., Morisaki, N., Shiina, R., and Saito, Y. Role of transforming growth factor-beta pathway in the mechanism of wound healing by saponin from Ginseng Radix rubra. Br J Pharmacol 1998;125(2):255-262. 9786496
  232. Lee S, Jung J, Cho D, and et al. Ginseng application on the skin enhances synthesis of extracellular matrix proteins:217. The Journal of Investigative Dermatology 1996;106(4):842.
  233. Ritter, G. and Dembicki, E. L. The variable effects of whole-leaf digitalis is a paradigm of the glycemic effects of ginseng. Arch Intern.Med 11-27-2000;160(21):3330-3331. 11088101
  234. Vuksan, V., V and Sievenpiper, J. L. The variable effects of whole-leaf digitalis is a paradigm of the glycemic effects of ginseng. Arch Intern Med 11-27-2000;160(21):3330-3331. 0011088102
  235. Dascalu, A., Sievenpiper, J. L., Jenkins, A. L., Stavro, M. P., Leiter, L. A., Arnason, J. T., and Vuksan, V. Five batches representative of Ontario-grown American ginseng root produce comparable reductions of postprandial glycemia in healthy individuals. Can J Physiol Pharmacol 2007;85(9):856-864. 18066131
  236. Edens NK, Reaves LA, and Henry DE. Extract of ginseng stimulates glucose transport and inhibits lipolysis in vitro. Diabetes 2001;50:A413.
  237. Konno, C., Sugiyama, K., Kano, M., Takahashi, M., and Hikino, H. Isolation and hypoglycaemic activity of panaxans A, B, C, D and E, glycans of Panax ginseng roots. Planta Med 1984;50(5):434-436. 6522508
  238. Oshima Y, Sato K, and Hikino H. Isolation and hypoglycemic activity of quinquefolans A, B, and C, glycans of Panax quinquefolium roots. J Natural Products 1987;50:188-190.
  239. Kang HY. Endogenous anabolic hormonal and growth factor responses to resistance excercise in carbohydrate and/or ginseng consumption. Medicine and Science in Sports and Excercise 1999;31:S125.
  240. Ling, C., Li, M., and Tan, J. [Experimental study on protective effect of Chinese herbal medicine on glucocorticoid receptor]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1999;19(5):302-303. 11783248
  241. Hiai, S., Yokoyama, H., Oura, H., and Yano, S. Stimulation of pituitary-adrenocortical system by ginseng saponin. Endocrinol Jpn 1979;26(6):661-665. 232038
  242. Pearce, P. T., Zois, I., Wynne, K. N., and Funder, J. W. Panax ginseng and Eleuthrococcus senticosus extracts--in vitro studies on binding to steroid receptors. Endocrinol Jpn 1982;29(5):567-573. 6303763
  243. Chen, J. C., Xu, M. X., Chen, L. D., Chen, Y. N., and Chiu, T. H. Effect of panax notoginseng extracts on inferior sperm motility in vitro. Am J Chin Med 1999;27(1):123-128. 10354824
  244. Chen, X. and Lee, T. J. Ginsenosides-induced nitric oxide-mediated relaxation of the rabbit corpus cavernosum. Br J Pharmacol 1995;115(1):15-18. 7647970
  245. Kim, H. J., Woo, D. S., Lee, G., and Kim, J. J. The relaxation effects of ginseng saponin in rabbit corporal smooth muscle: is it a nitric oxide donor? Br J Urol 1998;82(5):744-748. 9839593
  246. Choi, Y. D., Rha, K. H., and Choi, H. K. In vitro and in vivo experimental effect of Korean red ginseng on erection. J Urol 1999;162(4):1508-1511. 10492246
  247. Kim, YuA, Akoev, V. R., and Elemesov, R. E. Hyperosmotic hemolysis and antihemolytic activity of the saponin fraction and triterpene glycosides from Panax ginseng C A Meyer Membr Cell Biol 2000;14(2):237-251. 11093585
  248. Gao, R. L., Xu, C. L., and Jin, J. M. [Effect of total saponins of Panax ginseng on hematopoietic progenitor cells in normal human and aplastic anemia patients]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1992;12(5):285-2. 1392481
  249. Tang, Q., Hu, H., and Zhang, H. [Influence of Shenmai injection on blood serum tumor necrosis factor and bone marrow CD34+ cell's apoptosis of chronic aplastic anemia patient]. Zhongguo Zhong Yao Za Zhi 2005;30(16):1296-1298. 16245914
  250. Lee, H. U., Bae, E. A., Han, M. J., Kim, N. J., and Kim, D. H. Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury. Liver Int 2005;25(5):1069-1073. 16162168
  251. Cho, J., Park, W., Lee, S., Ahn, W., and Lee, Y. Ginsenoside-Rb1 from Panax ginseng C.A. Meyer activates estrogen receptor-alpha and -beta, independent of ligand binding. J Clin Endocrinol.Metab 2004;89(7):3510-3515. 15240639
  252. Liu, J., Burdette, J. E., Xu, H., Gu, C., van Breemen, R. B., Bhat, K. P., Booth, N., Constantinou, A. I., Pezzuto, J. M., Fong, H. H., Farnsworth, N. R., and Bolton, J. L. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 2001;49(5):2472-2479. 11368622
  253. Punnonen, R. and Lukola, A. Oestrogen-like effect of ginseng. Br Med J 10-25-1980;281(6248):1110. 7191760
  254. Tomoda, M., Hirabayashi, K., Shimizu, N., Gonda, R., Ohara, N., and Takada, K. Characterization of two novel polysaccharides having immunological activities from the root of Panax ginseng. Biol Pharm Bull 1993;16(11):1087-1090. 8312860
  255. Tong, L. S. and Chao, C. Y. Effects of ginsenoside Rg1 of Panax ginseng on mitosis in human blood lymphocytes in vitro. Am J Chin Med 1980;8(3):254-267. 7211745
  256. Jing, Y. and et al. A proprietary extract of Panax quinquefolius (CVT-E002) stimulates inflammatory cytokine secretion from monocytes and augments IFN-gamma secretion from NK cells in response to influenza virus stimulation. Internal Report
  257. Jie, Y. H., Cammisuli, S., and Baggiolini, M. Immunomodulatory effects of Panax Ginseng C.A. Meyer in the mouse. Agents Actions 1984;15(3-4):386-391. 6084415
  258. Kim, J. Y., Germolec, D. R., and Luster, M. I. Panax ginseng as a potential immunomodulator: studies in mice. Immunopharmacol Immunotoxicol 1990;12(2):257-276. 2229924
  259. Ro JY and Kim KH. The adjuvant activity of a single purified ginsenosids (Rb, Rg) from Korean Red Ginseng Radix. The Journal of Allergy and Clinical Immunology 1999;103:S210-S211.
  260. Zhou, D. L. and Kitts, D. D. Peripheral blood mononuclear cell production of TNF-alpha in response to North American ginseng stimulation. Can J Physiol Pharmacol 2002;80(10):1030-1033. 12450071
  261. Nakaya, T. A., Kita, M., Kuriyama, H., Iwakura, Y., and Imanishi, J. Panax ginseng induces production of proinflammatory cytokines via toll-like receptor. J Interferon Cytokine Res 2004;24(2):93-100. 14980073
  262. Liu, J., Wang, S., Liu, H., Yang, L., and Nan, G. Stimulatory effect of saponin from Panax ginseng on immune function of lymphocytes in the elderly. Mech Ageing Dev 8-31-1995;83(1):43-53. 8523901
  263. Daggfeldt A, Rivera E, and Hu S. Ginseng improve the antibody response to porcine parvovirus and Erysipelothrix rhusiopatiae. Scandinavian Journal of Immunology 1999;50:326.
  264. Mizuno, M., Yamada, J., Terai, H., Kozukue, N., Lee, Y. S., and Tsuchida, H. Differences in immunomodulating effects between wild and cultured Panax ginseng. Biochem Biophys Res Commun 5-16-1994;200(3):1672-1678. 8185624
  265. Srisurapanon, S., Rungroeng, K., Apibal, S., Cherdrugsi, P., Siripol, R., Vanich-Angkul, V., and Timvipark, C. The effect of standardized ginseng extract on peripheral blood leukocytes and lymphocyte subsets: a preliminary study in young health adults. J Med Assoc Thai 1997;80 Suppl 1:S81-S85. 9347651
  266. Smolina, T. P., Solov'eva, T. F., and Besednova, N. N. [Immunotropic activity of panaxans--bioglycans isolated from ginseng]. Antibiot Khimioter 2001;46(7):19-22. 11697239
  267. Cho, J. Y., Kim, A. R., Yoo, E. S., Baik, K. U., and Park, M. H. Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation. Planta Med 2002;68(6):497-500. 12094290
  268. Sonoda, Y., Kasahara, T., Mukaida, N., Shimizu, N., Tomoda, M., and Takeda, T. Stimulation of interleukin-8 production by acidic polysaccharides from the root of Panax ginseng. Immunopharmacology 1998;38(3):287-294. 9506829
  269. Deng, Y., Jing, Y., Campbell, A. E., and Gravenstein, S. Age-related impaired type 1 T cell responses to influenza: reduced activation ex vivo, decreased expansion in CTL culture in vitro, and blunted response to influenza vaccination in vivo in the elderly. J Immunol 3-15-2004;172(6):3437-3446. 15004143
  270. Miller, S. C. and Shan, J. J. CVT E002, 14 a proprietary extract of North American ginseng (Panax quinquefolium) enhances bone marrow and splenic natural killer (NK) cells and monocytes in leukemic mice, and variably influences other hemopoietic and immune cells. Book of abstracts: The North American Research Conference on Complementary and Integrative Medicine 5-24-2006;
  271. Wang, M., Guilbert, L. J., Li, J., Wu, Y., Pang, P., Basu, T. K., and Shan, J. J. A proprietary extract from North American ginseng (Panax quinquefolium) enhances IL-2 and IFN-gamma productions in murine spleen cells induced by Con-A. Int Immunopharmacol 2004;4(2):311-315. 14996422
  272. Sung, H., Kang, S. M., Lee, M. S., Kim, T. G., and Cho, Y. K. Korean red ginseng slows depletion of CD4 T cells in human immunodeficiency virus type 1-infected patients. Clin Diagn Lab Immunol 2005;12(4):497-501. 15817756
  273. Zhang ZZ, Wang MD, and Chen ZH. Pharmacological effects of Panax Notogiznseng on the heart. Acta Pharmaceutica Sinica 1980;15:385-390.
  274. Yamamoto, M., Kumagai, A., and Yamamura, Y. Plasma lipid-lowering and lipogenesis-stimulating actions of ginseng saponins in tumor-bearing rats. Am J Chin Med 1983;11(1-4):88-95. 6660220
  275. Lewis, R., Wake, G., Court, G., Court JA, Pickering, A. T., Kim, Y. C., and Perry, E. K. Non-ginsenoside nicotinic activity in ginseng species. Phytother Res 1999;13(1):59-64. 10189953
  276. Choi, S., Jung, S. Y., Lee, J. H., Sala, F., Criado, M., Mulet, J., Valor, L. M., Sala, S., Engel, A. G., and Nah, S. Y. Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes. Eur J Pharmacol 5-3-2002;442(1-2):37-45. 12020680
  277. Lu, Z. Q. and Dice, J. F. Ginseng extract inhibits protein degradation and stimulates protein synthesis in human fibroblasts. Biochem Biophys Res Commun 1-16-1985;126(1):636-640. 3882091
  278. Rimar, S., Lee-Mengel, M., and Gillis, C. N. Pulmonary protective and vasodilator effects of a standardized Panax ginseng preparation following artificial gastric digestion. Pulm Pharmacol 1996;9(4):205-209. 9160407
  279. Zhao, L., Xiong, S., Niu, R., Xu, Y., and Zhang, Z. Effect of shenmai injection on L-type calcium current of diaphragmatic muscle in rats. J Huazhong Univ Sci Technolog Med Sci 2004;24(4):376-378. 15587403
  280. Ye, D., Wu, P., and Niu, R. [Experimental study on effect of Shenmai injection in improving contractility of fatigue diaphragm in rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2000;20(9):679-681. 11789174
  281. Ben Hur, E. and Fulder, S. Effect of Panax ginseng saponins and Eleutherococcus senticosus on survival of cultured mammalian cells after ionizing radiation. Am J Chin Med 1981;9(1):48-56. 7304498
  282. Yonezawa M, Katoh N, and Takeda A. Restoration of radiation injury by ginseng II: some properties of the radioprotective substances. J Radiat Res 1981;22:336-343.
  283. Thatte, U., Bagadey, S., and Dahanukar, S. Modulation of programmed cell death by medicinal plants. Cell Mol Biol (Noisy.-le-grand) 2000;46(1):199-214. 10726985
  284. He, Z., Yang, X., and Zhang, S. [Effect of Shenmai injection on morphological structure of kidney and peritoneum in rats with 5/6 nephrectomy]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1998;18(9):553-555. 11475735
  285. Rhee, Y. H., Lee, S. P., Honda, K., and Inoue, S. Panax ginseng extract modulates sleep in unrestrained rats. Psychopharmacology (Berl) 1990;101(4):486-488. 2388971
  286. Yoo, H. H., Yokozawa, T., Satoh, A., Kang, K. S., and Kim, H. Y. Effects of ginseng on the proliferation of human lung fibroblasts. Am J Chin Med 2006;34(1):137-146. 16437746
  287. Kenarova, B., Neychev, H., Hadjiivanova, C., and Petkov, V. D. Immunomodulating activity of ginsenoside Rg1 from Panax ginseng. Jpn J Pharmacol 1990;54(4):447-454. 2087006
  288. Kimura, Y., Sumiyoshi, M., Kawahira, K., and Sakanaka, M. Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice. Br J Pharmacol 2006;148(6):860-870. 16770323
  289. Choi, S. Epidermis proliferative effect of the Panax ginseng ginsenoside Rb2. Arch Pharm Res 2002;25(1):71-76. 11885696
  290. Leung, K. W., Yung, K. K., Mak, N. K., Yue, P. Y., Luo, H. B., Cheng, Y. K., Fan, T. P., Yeung, H. W., Ng, T. B., and Wong, R. N. Angiomodulatory and neurological effects of ginsenosides. Curr Med Chem 2007;14(12):1371-1380. 17504218
  291. Radad, K., Gille, G., Liu, L., and Rausch, W. D. Use of ginseng in medicine with emphasis on neurodegenerative disorders. J Pharmacol Sci 2006;100(3):175-186. 16518078
  292. Ng, T. B. Pharmacological activity of sanchi ginseng (Panax notoginseng). J Pharm Pharmacol 2006;58(8):1007-1019. 16872547
  293. Meijerman, I., Beijnen, J. H., and Schellens, J. H. Herb-drug interactions in oncology: focus on mechanisms of induction. Oncologist 2006;11(7):742-752. 16880233
  294. Han, M., Han, L. M., Wang, Q. S., Bai, Z. H., and Fang, X. L. [Mechanism of oral absorption of panaxnotoginseng saponins]. Yao Xue Xue Bao 2006;41(6):498-505. 16927822
  295. Han, M. and Fang, X. L. Difference in oral absorption of ginsenoside Rg1 between in vitro and in vivo models. Acta Pharmacol Sin 2006;27(4):499-505. 16539852
  296. Liang, F. and Hua, J. X. Absorption profiles of sanchinoside R1 and ginsenoside Rg1 in the rat intestine. Eur J Drug Metab Pharmacokinet 2005;30(4):261-268. 16435571
  297. Wu, Y. J., Zhu, X. Y., Sha, X. Y., and Fang, X. L. [The pharmacokinetics and pharmacodynamics of intranasal preparation of Panax notoginseng Saponins]. Yao Xue Xue Bao 2005;40(4):377-381. 16011272
  298. Xu, Q. F., Fang, X. L., Chen, D. F., and Li, J. C. [Studies on formulations of Panax notoginsenosides for intranasal administration]. Yao Xue Xue Bao  2003;38(11):859-862. 14992002
  299. Xie, H. T., Wang, G. J., Chen, M., Jiang, X. L., Li, H., Lv, H., Huang, C. R., Wang, R., and Roberts, M. Uptake and metabolism of ginsenoside Rh2 and its aglycon protopanaxadiol by Caco-2 cells. Biol Pharm Bull 2005;28(2):383-386. 15684507
  300. Xu, Q. F., Fang, X. L., and Chen, D. F. Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats.
    J Ethnopharmacol 2003;84(2-3):187-192. 12648814
  301. Lee, P. S., Song, T. W., Sung, J. H., Moon, D. C., Song, S., and Chung, Y. B. Pharmacokinetic characteristics and hepatic distribution of IH-901, a novel intestinal metabolite of ginseng saponin, in rats. Planta Med 2006;72(3):204-210. 16534723
  302. Paek, I. B., Moon, Y., Kim, J., Ji, H. Y., Kim, S. A., Sohn, D. H., Kim, J. B., and Lee, H. S. Pharmacokinetics of a ginseng saponin metabolite compound K in rats. Biopharm Drug Dispos 2006;27(1):39-45. 16302287
  303. Hasegawa, H., Suzuki, R., Nagaoka, T., Tezuka, Y., Kadota, S., and Saiki, I. Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acid-conjugate of protopanaxatriol. Biol Pharm Bull 2002;25(7):861-866. 12132658
  304. Akao, T., Kida, H., Kanaoka, M., Hattori, M., and Kobashi, K. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol 1998;50(10):1155-1160. 9821663
  305. Liu, Y. M., Yang, L., Zeng, X., Deng, Y. H., Feng, Y., and Liang, W. X. [Pharmacokinetics of ginsenosides Rg1 and Re in Shenmai injection]. Yao Xue Xue Bao 2005;40(4):365-368. 16011269

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